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  • 1
    Online Resource
    Online Resource
    Strong Expression of Chemokine Receptor CXCR 4 by Renal Cell Carcinoma Correlates with Advanced Disease
    Hindawi Limited ; 2008
    In:  Journal of Oncology Vol. 2008 ( 2008), p. 1-6
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    In: Journal of Oncology, Hindawi Limited, Vol. 2008 ( 2008), p. 1-6
    Abstract: Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptor CXCR 4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence of CXCR 4 expression on the progression of human renal cell carcinoma. CXCR 4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity of CXCR 4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities of CXCR 4 expression. Strong CXCR 4 expression of renal cell carcinoma was significantly associated with advanced T-status ( P = .039 ), tumor dedifferentiation ( P = .0005), and low hemoglobin ( P = .039). In summary, strong CXCR 4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.
    Type of Medium: Online Resource
    ISSN: 1687-8450 , 1687-8469
    URL: Article
    DOI: 10.1155/2008/626340
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2008
    detail.hit.zdb_id: 2461349-6
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  • 2
    Online Resource
    Online Resource
    Biomechanical Effects of Incisional Negative Wound Pressure Dressing: An Ex Vivo Model Using Human and Porcine Abdominal Walls
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018-12-30), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018-12-30), p. 1-7
    Abstract: Introduction . Incisional negative pressure wound therapy (iNPWT) has been of recent interest in different surgical fields as beneficial outcomes on high-risk wounds have been reported. Nevertheless, its mechanisms of function are not widely studied to date. Methods . We established two ex vivo setups of iNPWT in porcine and human abdominal wall for measuring pressures within the wound which result from iNPWT application. For pressure measurements, a high-resolution manometry catheter and a balloon catheter probe were used in a wound sealed with either a commercially available PREVENA VAC kit or a self-made iNPWT kit. Furthermore, we evaluated seroma evacuation by iNPWT. Results . Both setups showed similar characteristics of pressure curves within the wound when applying increasing negative pressures. Application of high pressures did not result in a similar increase in wound pressure. Only subtotal evacuation of seroma by iNPWT application (about 75% of volume) could be detected. Conclusion. Our ex vivo model of iNPWT in porcine and human abdominal wall could show reproducible measurements of pressures within the wounds in both types of tissue. As intrawound pressures did not increase in the same way as the applied negative pressure, we suggest that our results do not advocate the idea of using iNPWT for wound care especially as seroma evacuation remains insufficient.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/7058461
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 3
    Online Resource
    Online Resource
    Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases
    Hindawi Limited ; 2019
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 2019 ( 2019-04-01), p. 1-12
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 2019 ( 2019-04-01), p. 1-12
    Abstract: Background . Loss of LLGL1 has been associated with loss of cellular adhesion and dissemination of cells from colorectal cancer and malignant melanoma. Regulation and relevance of LLGL1 were analyzed in gastric cancer patients with lymphatic and distant dissemination. Furthermore, LLGL1 expression was analyzed in relation to the cellular adhesion protein E-cadherin . Methods . LLGL1 and E-cadherin transcription levels were evaluated in 56 gastric cancer patients and five gastric cancer cell lines. IHC staining for LLGL1 was performed on 39 gastric cancer specimens. LLGL1 was stably transfected into LLGL1 negative gastric cancer cell line SNU16 (del(17) (p11.2)) for functional in vitro assays and a xenograft bioassay. Results . Gastric cancer specimens and cell lines displayed LLGL1 and E-cadherin expression levels with variable intensity. In gastric mucosa, LLGL1 exhibited weak cytoplasmic and strong cortical staining. Loss of LLGL1 expression occurred in 65% of gastric cancers and significantly correlated with loss of E-cadherin expression (P=0.00009). Loss of LLGL1 expression was associated with the diffuse type of gastric cancer (P=0.029) with peritoneal carcinomatosis (M1; P=0.006) and with female gender (P=0.017). Stable reexpression of LLGL1 in SNU16 cells significantly increased both plastic surface adhesion and extracellular matrix proteins laminin and fibronectin, but had no impact on in vitro proliferation, apoptosis, or invasion or on in vivo proliferation or differentiation in our xenograft bioassay. Conclusion . LLGL1 is coexpressed with E-cadherin. Loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases. LLGL1 does not impact on proliferation or epithelial-mesenchymal transition (EMT) rather increasing cellular adhesion.
    Type of Medium: Online Resource
    ISSN: 2291-2789 , 2291-2797
    URL: Article
    DOI: 10.1155/2019/2920493
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2762184-4
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