In:
EMBO reports, EMBO, Vol. 17, No. 11 ( 2016-11), p. 1641-1656
Abstract:
image Using a histone FRAP method, this study identifies Gadd45a as a chromatin relaxer and somatic cell reprogramming enhancer. Gadd45a destabilizes histone– DNA interactions and facilitates the binding of Yamanaka factors to their targets. FRAP is used to assess heterochromatin/euchromatin dynamics in somatic cell reprogramming. Gadd45a is a chromatin relaxer and improves somatic cell reprogramming. Gadd45a destabilizes histone– DNA interactions and facilitates the binding of Yamanaka factors to their targets.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201642402
Language:
English
Publisher:
EMBO
Publication Date:
2016
detail.hit.zdb_id:
2025376-X
SSG:
12
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