Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 1990
    In:  Speech Communication Vol. 9, No. 1 ( 1990-2), p. 31-34
    In: Speech Communication, Elsevier BV, Vol. 9, No. 1 ( 1990-2), p. 31-34
    Type of Medium: Online Resource
    ISSN: 0167-6393
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1990
    detail.hit.zdb_id: 625711-2
    detail.hit.zdb_id: 1460279-9
    SSG: 7,11
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 115, No. 50 ( 2018-12-11)
    Abstract: Cancer immunotherapy has emerged as an effective therapy in a variety of cancers. However, a key challenge in the field is that only a subset of patients who receive immunotherapy exhibit durable response. It has been hypothesized that host genetics influences the inherent immune profiles of patients and may underlie their differential response to immunotherapy. Herein, we systematically determined the association of common germline genetic variants with gene expression and immune cell infiltration of the tumor. We identified 64,094 expression quantitative trait loci (eQTLs) that associated with 18,210 genes (eGenes) across 24 human cancers. Overall, eGenes were enriched for their being involved in immune processes, suggesting that expression of immune genes can be shaped by hereditary genetic variants. We identified the endoplasmic reticulum aminopeptidase 2 ( ERAP2 ) gene as a pan-cancer type eGene whose expression levels stratified overall survival in a subset of patients with bladder cancer receiving anti–PD-L1 (atezolizumab) therapy. Finally, we identified 103 gene signature QTLs (gsQTLs) that were associated with predicted immune cell abundance within the tumor microenvironment. Our findings highlight the impact of germline SNPs on cancer-immune phenotypes and response to therapy; and these analyses provide a resource for integration of germline genetics as a component of personalized cancer immunotherapy.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2018
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2007
    In:  Proceedings of the National Academy of Sciences Vol. 104, No. 2 ( 2007-01-09), p. 450-455
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 104, No. 2 ( 2007-01-09), p. 450-455
    Abstract: Establishing phase relationships between earth-system components during periods of rapid global change is vital to understanding the underlying processes. It requires records of each component with independent and accurate chronologies. Until now, no continental record extending from the present to the penultimate glacial had such a chronology to our knowledge. Here, we present such a record from the annually laminated sediments of Lago Grande di Monticchio, southern Italy. Using this record we determine the duration (17.70 ± 0.20 ka) and age of onset (127.20 ± 1.60 ka B.P.) of the last interglacial, as reflected by terrestrial ecosystems. This record also reveals that the transitions at the beginning and end of the interglacial spanned only ≈100 and 150 years, respectively. Comparison with records of other earth-system components reveals complex leads and lags. During the penultimate deglaciation phase relationships are similar to those during the most recent deglaciation, peaks in Antarctic warming and atmospheric methane both leading Northern Hemisphere terrestrial warming. It is notable, however, that there is no evidence at Monticchio of a Younger Dryas-like oscillation during the penultimate deglaciation. Warming into the first major interstadial event after the last interglacial is characterized by markedly different phase relationships to those of the deglaciations, warming at Monticchio coinciding with Antarctic warming and leading the atmospheric methane increase. Diachroneity is seen at the end of the interglacial; several global proxies indicate progressive cooling after ≈115 ka B.P., whereas the main terrestrial response in the Mediterranean region is abrupt and occurs at 109.50 ± 1.40 ka B.P.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2007
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages