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  • Knapstad, Marit  (3)
  • Pharmacy  (3)
  • Psychology  (3)
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  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 2023
    In:  Psychotherapy and Psychosomatics Vol. 92, No. 3 ( 2023), p. 193-202
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 92, No. 3 ( 2023), p. 193-202
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The temporal relationship between symptoms and functioning in the context of cognitive behavioral therapy (CBT) for anxiety and depression is not fully understood, and there are few high-quality studies that have examined to what extent late intervention effects of CBT on functioning are mediated by initial intervention effects on symptoms while accounting for the initial effects on functioning and vice versa. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of the study was to investigate whether intervention effects on symptoms and functioning at 12-month follow-up were mediated by intervention effects on these outcomes at 6-month follow-up. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Participants with anxiety and/or mild-to-moderate depression were randomly assigned to a primary mental health care service ( 〈 i 〉 n 〈 /i 〉 = 463) or treatment-as-usual ( 〈 i 〉 n 〈 /i 〉 = 215). Main outcomes were depressive symptoms (Patient Health Questionnaire [PHQ-9]), anxiety (General Anxiety Disorder-7 [GAD-7] ), and functioning (Work and Social Adjustment Scale [WSAS]). Direct/indirect effects were derived using the potential outcomes and counterfactual framework. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The intervention effect on functioning at 12 months was largely explained by intervention effects at 6 months on depressive symptoms (51%) and functioning (39%). The intervention effect on depressive symptoms at 12 months was largely explained by the intervention effect at 6 months on depressive symptoms (70%) but not by functioning at 6 months. The intervention effect on anxiety at 12 months was only partly accounted for by intervention effects at 6 months on anxiety (29%) and functioning (10%). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The findings suggest that late intervention effects of CBT on functioning were to a substantial degree explained by initial intervention effects on depressive symptoms even after accounting for initial effects on functioning. Our results support the importance of symptoms as an outcome in the context of CBT delivered in primary health care.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    RVK:
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 89, No. 2 ( 2020), p. 90-105
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The innovative treatment model Improving Access to Psychological Therapies (IAPT) and its Norwegian adaptation, Prompt Mental Health Care (PMHC), have been evaluated by cohort studies only. Albeit yielding promising results, the extent to which these are attributable to the treatment thus remains unsettled. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To investigate the effectiveness of the PMHC treatment compared to treatment as usual (TAU) at 6-month follow-up. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A randomized controlled trial with parallel assignment was performed in two PMHC sites (Sandnes and Kristiansand) and enrolled clients between November 9, 2015 and August 31, 2017. Participants were 681 adults (aged ≥18 years) considered for admission to PMHC due to anxiety and/or mild to moderate depression (Patient Health Questionnaire [PHQ-9]/Generalized Anxiety Disorder scale [GAD-7] scores above cutoff). These were randomly assigned (70:30 ratio; 〈 i 〉 n 〈 /i 〉 = 463 to PMHC, 〈 i 〉 n 〈 /i 〉 = 218 to TAU) with simple randomization within each site with no further constraints. The main outcomes were recovery rates and changes in symptoms of depression (PHQ-9) and anxiety (GAD-7) between baseline and follow-up. Primary outcome data were available for 73/67% in PMHC/TAU. Sensitivity analyses based on observed patterns of missingness were also conducted. Secondary outcomes were work participation, functional status, health-related quality of life, and mental well-being. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A reliable recovery rate of 58.5% was observed in the PMHC group and of 31.9% in the TAU group, equaling a between-group effect size of 0.61 (95% CI 0.37 to 0.85, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). The differences in degree of improvement between PMHC and TAU yielded an effect size of –0.88 (95% CI –1.23 to –0.43, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) for PHQ-9 and –0.60 (95% CI –0.90 to –0.30, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) for GAD-7 in favor of PMHC. All sensitivity analyses pointed in the same direction, with small variations in point estimates. Findings were slightly more robust for depressive than anxiety symptoms. PMHC was also more effective than TAU in improving all secondary outcomes, except for work participation ( 〈 i 〉 z 〈 /i 〉 = 0.415, 〈 i 〉 p 〈 /i 〉 = 0.69). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The PMHC treatment was substantially more effective than TAU in alleviating the burden of anxiety and depression. This adaptation of IAPT is considered a viable supplement to existing health services to increase access to effective treatment for adults who suffer from anxiety and mild to moderate depression. A potential effect on work participation needs further examination.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    RVK:
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Online Resource
    Online Resource
    S. Karger AG ; 2017
    In:  Psychotherapy and Psychosomatics Vol. 86, No. 6 ( 2017), p. 382-384
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 86, No. 6 ( 2017), p. 382-384
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    RVK:
    RVK:
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2017
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
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