In:
Natural Product Communications, SAGE Publications, Vol. 10, No. 6 ( 2015-06), p. 1934578X1501000-
Abstract:
In the present study, the chemical composition and antioxidant potential of an essential oil of ginger rhizomes from Ecuador was elucidated. The analysis of the essential oil by GC/FID/MS resulted in identification of 71 compounds, of which the main are citral (geranial 10.5% and neral 9.1%), α-zingiberene (17.4%), camphene (7.8%), α-farnesene (6.8%) and β-sesquiphellandrene (6.7%). The in vitro antioxidant activity of the essential oil expressed by IC 50 in descending order is: hydroxyl radical (OH • ) scavenging (0.0065 μg/mL) 〉 chelating capacity (0.822 μg/mL) 〉 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical cation (ABTS •+ ) scavenging (3.94 μg/mL) 〉 xanthine oxidase inhibition (138.0 μg/mL) 〉 oxygen radical (CV) scavenging (404.0 μg/mL) 〉 2,2-diphenyl-1-picrylhydrazyl radical (DPPH • ) scavenging (675 μg/mL). Lipid peroxidation inhibition of the essential oil was less efficient than butylhydroxy-toluol (BHT) in both stages, i.e. hydroperoxide and malondialdehyde formation. In vivo studies in Saccharomyces cerevisiae demonstrated a significant dose-dependent increase in antioxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), blocking the oxidation processes in yeast cells. Moreover, ginger essential oil in concentrations of 1.6 mg/mL increases the viability of cells to oxidative stress induced by H 2 O 2 .
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1501000672
Language:
English
Publisher:
SAGE Publications
Publication Date:
2015
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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