In:
Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 13, No. 1 ( 2011-04-12), p. 290-299
Abstract:
Adenosine, adenosine-5′-phosphoric acid (AMP), adenosine-5′-triphosphate (ATP), guanosine-5′-triphosphate (GTP), uridine, uridine-5′-triphosphate (UTP), and cytidine diphosphate-5′-choline (CDPCh) were studied in vitro and in vivo. The intraventricular injection of high doses of adenosine, ATP, and methacholine into rats elicited clonic-tonic convulsions or an akinetic state, or both. Perfusion of frog hearts in situ with equimolar concentrations of the “high-energy” compounds, with the exception of ATP, failed to exert any positive inotropic effects, ATP did not potentiate the inotropic actions of (—)-adrenaline or (—)-noradrenaline. The cholinergic-like properties of adenosine and ATP were partially antagonised by concomitant perfusion with methylene blue, ATP, but not adenosine, obliterated transitorily, the cardio-toxicity of pilocarpine. The inhibition of the isolated clam heart by AMP and ATP qualitatively resembled the effects of acetylcholine (Ach). Antagonism of the cardio-depressant properties of AMP and ATP by benzoquinonium and 5-hydroxytryptamine (5-HT) also supports previous evidence that the adenyl compounds act similarly to the cholinergic mediator, ATP produced marked contractions and a tonotropic effect on the oestrogenised, isolated, quiescent rat uterus; these effects were destroyed by low concentrations of (—)-adrenaline and papaverine. Adenosine, AMP, and CDPCh in equimolarities elicited no response from this test preparation.
Type of Medium:
Online Resource
ISSN:
2042-7158
,
0022-3573
DOI:
10.1111/j.2042-7158.1961.tb11826.x
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2011
detail.hit.zdb_id:
2041988-0
detail.hit.zdb_id:
2050532-2
SSG:
15,3
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