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Format: Online-Ressource (digital)

ISBN: 9780387746722

Series Statement: Advances in Experimental Medicine and Biology 612

Content: This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Content: Relaxin and Related Peptides discusses the established paradigms, the contradictions, and the most recent findings and future directions in the field of relaxin research. The array of diverse topics are highlighted, ranging from evolution of relaxin family peptides and receptors to their cell signaling, from the role of relaxin in reproduction to the newly discovered functions in cancer progression and in the nervous system. This book includes chapters written by well-known experts in the relaxin field who are actively involved in shaping this rapidly evolving science. The four major ongoing areas of research described in this book will likely attract investigators for years to come, since many basic scientific questions remain unanswered at this time. The availability of structural databases, new experimental techniques, and high quality hormone preparations, antibodies and other reagents enable rigorous investigation. Relaxin and Related Peptides offers a fresh perspective along with different points of view, opinions and disagreements.

Note: Includes bibliographical references and index , CONTENTS; PREFACE; FOREWORD; 1. THE EVOLUTION OF THE RELAXIN PEPTIDE FAMILY AND THEIR RECEPTORS; Abstract; Introduction; The Relaxin Peptides; Relaxin; Relaxin-3; Insulin-Like Peptide 3 (INSL3); Insulin-Like Peptide 4 (INSL4); Insulin-Like Peptide 5 (INSL5); Insulin-Like Peptide 6 (INSL6); The Evolution of the Relaxin Peptide Family; The Relaxin Peptide Family Receptors; Leucine Rich Repeat Containing G Protein-Coupled Receptors 7 and (LGR7 and LGR8); GPCR135 and GPCR142; Receptor Nomenclature; The Evolution of the Relaxin Peptide Family Receptors , Co-Evolution of the Relaxin Peptide Family and Their Receptors2. RELAXIN, THE RELAXIN-LIKE FACTOR AND THEIR RECEPTORS; Abstract; Relaxin; RLF; 3. DIVERSE SIGNALLING MECHANISMS USED BY RELAXIN IN NATURAL CELLS AND TISSUES: THE EVOLUTION OF A ""NEOHORMONE''; Abstract; Introduction; Evolution of Signalling Systems; Relaxin as a Model Neohormone System; Stimulation of cAMP Accumulation; Relaxin Stimulation of PI3-Kinase and Protein Kinase C5 (PKC5); Is Relaxin Action Connected to Ca++ Flux in Stimulated Cells?; Relaxin Can Act Through the Glucocorticoid Receptor (GR) , Downstream Effects of Relaxin-Dependent Cell SignallingLocal Relaxin Systems; Concluding Remarks; 4. RELAXIN PHYSIOLOGY IN THE FEMALE REPRODUCTIVE TRACT DURING PREGNANCY; Abstract; Introduction; Relaxin Receptors; Effects of Relaxin on the Cervix; Effects of Relaxin on the Vagina; Effects of Relaxin on the Uterus; Summary; 5. RELAXIN AND RELATED PEPTIDES IN MALE REPRODUCTION; Abstract; Relaxin in Male Reproduction; Other Relaxin Peptides in Male Reproduction; Insulin-Like Peptide 3 (INSL3); Summary and Future Directions; 6. THE VASCULAR ACTIONS OF RELAXIN; Abstract; Introduction , Part 1. Contribution of Relaxin to Normal Vascular FunctionPart 2. Relaxin and Vascular Dysfunction: Implications for Relaxin as a Therapeutic Agent; Part 3. Controversies, Unresolved Issues and Future Directions; 7. THE EFFECTS OF RELAXIN ON EXTRACELLULAR MATRIX REMODELING IN HEALTH AND FIBROTIC DISEASE; Abstract; Introduction; The Extracellular Matrix (ECM); Fibroblasts; Fibrosis; The Matrix Remodeling Effects of Exogenous Relaxin; The Protective Effects of Endogenous Relaxin; Mechanism of Relaxin's Antifibrotic Properties; Conclusions , 8. RELAXIN-LIKE LIGAND-RECEPTOR SYSTEMS ARE AUTOCRINE/PARACRINE EFFECTORS IN TUMOR CELLS AND MODULATE CANCER PROGRESSION AND TISSUE INVASIVENESSAbstract; Introduction; Prostate Cancer; Thyroid Cancer; Cancer of Female Organs with Reproductive Functions; Future Directions; 9. RELAXIN-FAMILY PEPTIDE AND RECEPTOR SYSTEMS IN BRAIN; Abstract; Discovery of Relaxin Family Genes and Peptides; Human and Rodent Relaxin Family Peptides - Gene Characteristics and Biosynthesis; Relaxin Family Peptide Receptors: Discovery, Distribution and Structure-Activity , Relaxin and Related Peptides: Peripheral and Central Distribution

Additional Edition: ISBN 9780387746708

Additional Edition: Buchausg. u.d.T. Relaxin and related peptides New York, NY : Springer Science+Business Media LLC, 2007 ISBN 9780387746708

Additional Edition: ISBN 0387746706

Language: English

Subjects: Biology

Keywords: Relaxin ; Physiologische Chemie ; Relaxin ; Konferenzschrift ; Aufsatzsammlung

DOI: 10.1007/978-0-387-74672-2

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Format: Online-Ressource , v.: digital

ISBN: 9780387095509

Series Statement: Advances in Experimental Medicine and Biology 635

Note: In: Springer-Online

Language: English

Subjects: Biology

Keywords: Electronic books

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Format: Online-Ressource (digital)

ISBN: 9789048122592

Series Statement: Advances in Experimental Medicine and Biology 648

Additional Edition: ISBN 9789048122585

Additional Edition: Buchausg. u.d.T. ISBN 978-90-481-2258-5

Language: English

Subjects: Biology

Keywords: Glomus caroticum ; Chemorezeptor

DOI: 10.1007/978-90-481-2259-2

URL: Volltext  (lizenzpflichtig)

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Format: Online-Ressource (digital)

ISBN: 9780387767154

Series Statement: Advances in Experimental Medicine and Biology 621

Content: This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.

Content: This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring. The journey starts with a description of the classical guidance signals such as the netrins, the semaphorins, the ephrins or the Slit family. The question of the exact definition of a guidance signal is addressed in a chapter which discusses whether neurotrophic factors can be considered as guidance cues. This complex question is also considered in a chapter presenting the role of adhesion molecules during axon guidance and the report of compelling evidence for a guidance effect of neurotransmitters. The diversity of the molecular cues used by growth cones to reach their targets is finally illustrated in a chapter describing the unexpected role of morphogenes as direct guidance signals.

Note: Includes bibliographical references and index , CONTENTS; PREFACE; 1. MOLECULAR MECHANISMS OF AXONAL GROWTH; Introduction; The Neuronal Growth Cone and its Cytoskeletal Organization; Mechanisms of Axonal Elongation; Regulation of the Cytoskeleton by Extracellular Cues, Role of Rho-GTPases; Growth Cone of Regenerating Axons; 2. NETRINS AND THEIR RECEPTORS; Introduction; Netrin Structure; Functional Roles for Netrins during Nervous System Development; Netrin Signal Transduction; Netrin in the Adult Nervous System; Conclusion and Perspectives; 3.Eph RECEPTORS AND EPHRIN LIGANDS IN AXON GUIDANCE; Introduction; Molecular Structure , Mechanisms of Signal TransductionFunctional Implications during Nervous System Development; Conclusion and Perspectives; 4. ROLE OF SEMAPHORINS DURING AXON GROWTH AND GUIDANCE; Introduction; Functional Roles of Semaphorins during Axon Guidance; Receptors of Secreted-Semaphorins: The Neuropilins; Receptors of Transmembrane-Semaphorins: The Plexin Family; Other Receptors Associated with Semaphorin Signaling; Intracellular Signal Transduction; Conclusion; 5. SLITS AND THEIR RECEPTORS; Introduction; Robo Partners; Molecular Control of Slit and Robo Expression , Multiple Functions for Slit/Robo in the Nervous SystemA Role for Slit and Robo in Neurological Disorders?; Perspectives; 6. NEUROTROPHIC FACTORS: ARE THEY AXON GUIDANCE MOLECULES?; Introduction; Evaluation of Neurotrophic Factors as Axon Guidance Molecules; The Discovery of the Neurotrophins; The Extended Family of Neurotrophic Factors; Neurotrophic Factors Can Promote Axon Growth and Orient Axons in Vitro; Neurotrophic Factors and Axon Guidance Molecules Use Common Signalling Pathways; The Role of Signalling Pathways in Axonal Chemoattraction by Neurotrophins and Netrin-l , Role of cAMP and Calcium Concentrations in ChemoattractionIn Vivo Tests of Neurotrophic Factors in Axon Guidance; Role of Neurotrophic Factors in Branching; Conclusions; 7. THE ROLE OF CELL ADHESION MOLECULES IN AXON GROWTH AND GUIDANCE; Introduction; Molecular Structure; Biophysical and Signaling Mechanisms; Functional Implication; Conclusion; 8. NEUROTRANSMITTERS AND THE DEVELOPMENT OF NEURONAL CIRCUITS; Introduction; Effects of Neurotransmitters on Growth Cone Steering; Glutamate: An Excitatory Transmitter and a Versatile Developmental Signal , Acetylcholine Acts as a Neuronal Guidance Signal during Brain DevelopmentThere Is More to GABA Than Synaptic Inhibition; Conclusions; 9. THE HEDGEHOG, TGF-ß/BMP AND Wnt FAMILIES OF MORPHOGENS IN AXON GUIDANCE; Introduction; Morphogens, Cell Fate Specification and Tissue Patterning; Morphogens in Axon Guidance; Interpreting Positional Information: Signaling Components in Axon Guidance and Cell Fate Specification; Conclusions and Perspectives; 10. THE ROLE OF CYCLIC NUCLEOTIDES IN AXON GUIDANCE; Introduction; Molecular Structure of Cyclic Nucleotides; Mechanisms of Signal Transduction , Functional Implications during Nervous System Development

Additional Edition: ISBN 9780387767147

Additional Edition: Buchausg. u.d.T. Axon growth and guidance New York, NY : Springer [u.a.], 2007 ISBN 9780387767147

Additional Edition: ISBN 0387767142

Language: English

Subjects: Biology

Keywords: Axon ; Physiologie ; Nervensystem ; Wachstum ; Axon ; Wachstum ; Genregulation ; Aufsatzsammlung

DOI: 10.1007/978-0-387-76715-4

URL: Volltext

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UID:

Format: Online-Ressource (digital)

ISBN: 9780387788852

Series Statement: Advances in Experimental Medicine and Biology 631

Content: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.

Content: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.

Note: Includes bibliographical references and index , CONTENTS; 1. INTRODUCTION TO BACTERIAL SIGNAL TRANSDUCTION NETWORKS; 2. THE PHOQ/PHOP REGULATORY NETWORK OF SALMONELLA ENTERICA; 3. STRUCTURAL BASIS OF THE SIGNAL TRANSDUCTION IN THE TWO-COMPONENT SYSTEM; 4. THE TWO-COMPONENT NETWORK AND THE GENERAL STRESS SIGMA FACTOR RPOS (OS) IN ESCHERICHIA COLI; 5. SMALL RNAS CONTROLLED BY TWO-COMPONENT SYSTEMS; 6. TWO-COMPONENT SIGNALING AND GRAIN NEGATIVE ENVELOPE STRESS RESPONSE SYSTEMS; 7. DUAL REGULATION WITH SER/THR KINASE CASCADE AND A HIS/ASP TCS IN MYXOCOCCUS XANTHUS , 8. TWO-COMPONENT SIGNALING SYSTEMS AND CELL CYCLE CONTROL IN CAULOBACTER CRESCENTUS9. REGB/REGA, A GLOBAL REDOX-RESPONDING TWO-COMPONENT SYSTEM; 10. THE BVGS/BVGA PHOSPHORELAY SYSTEM OF PATHOGENIC BORDETELLAE: STRUCTURE, FUNCTION AND EVOLUTION; 11. CAPTURING THE VIRA/VIRG TCS OF AGRPBACTERIUM TUMEFACIENS; 12. QUORUM SENSING AND BIOFILM FORMATION BY STREPTOCOCCUS MUTANS; 13 THE ROLES OF TWO-COMPONENT SYSTEMS IN VIRULENCE OF PATHOGENIC ESCHERICHIA COLI AND SHIGELLA SPP; 14. VANCOMYCIN RESISTANCE VANS/VANR TWO-COMPONENT SYSTEMS , 15 TEARING DOWN THE WALL: PEPTIDOGLYCAN METABOLISM AND THE WALK/WALKR (YYCG/YYCF) ESSENTIAL TWO-COMPONENT SYSTEM16. INHIBITORS TARGETING TWO-COMPONENT SIGNAL TRANSDUCTION; INDEX

Additional Edition: ISBN 9780387788845

Additional Edition: Buchausg. u.d.T. Bacterial signal transduction: networks and drug targets New York [u.a.] : Springer Science+Business Media, LLC [u.a.], 2008 ISBN 9780387788845

Additional Edition: ISBN 0387788840

Language: English

Subjects: Biology

Keywords: Bakterien ; Signaltransduktion ; Genregulation ; Pharmakologie ; Aufsatzsammlung

DOI: 10.1007/978-0-387-78885-2

URL: Volltext

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UID:

Format: Online-Ressource (digital)

ISBN: 9780387859989

Series Statement: Advances in Experimental Medicine and Biology 645

Content: This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

Content: Covers various aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. This book pays attention to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation

Note: Includes bibliographical references and index , Selected conference papers , CONTENTS; AIR AND FIRE - Carl Wilhelm Scheele, Torbern Bergman, The Royal Society of Sciences and the discovery of oxygen in Uppsala in 1772; MATHEMATICAL MODELING OF THE INTERACTION BETWEEN OXYGEN, NITRIC OXIDE AND SUPEROXIDE; HAEMOGLOBIN SATURATION CONTROLS THE RED BLOOD CELL MEDIATED HYPOXIC VASORELAXATION; BLOOD VESSEL SPECIFIC VASO-ACTIVITY TO NITRITE UNDER NORMOXIC AND HYPOXIC CONDITIONS; NITRITE-INDUCED IMPROVED BLOOD CIRCULATION ASSOCIATED WITH AN INCREASE IN A POOL OF RBC-NO WITH NO BIOACTIVITY; THE CONTROL OF OXIDATIVE PHOSPHORYLATION IN THE ADRENAL GLAND (Y1) CELL LINE , REPLICATION OF MURINE MITOCHONDRIAL DNA FOLLOWING IRRADIATIONEFFECTS OF ANESTHESIA ON BRAIN MITOCHONDRIAL FUNCTION, BLOOD FLOW, IONIC AND ELECTRICAL ACTIVITY MONITORED IN VIVO; THE INFLUENCE OF FLOW REDISTRIBUTION ON WORKING RAT MUSCLE OXYGENATION; HETEROGENEITY OF CAPILLARY SPACING IN THE HYPERTROPHIED PLANTARIS MUSCLE FROM YOUNG-ADULT AND OLD RATS; MICROVASCULARITY OF THE LUMBAR ERECTOR SPINAE MUSCLE DURING SUSTAINED PRONE TRUNK EXTENSION TEST; FIBER CAPILLARY SUPPLY RELATED TO FIBER SIZE ANDOXIDATIVE CAPACITY IN HUMAN AND RAT SKELETAL MUSCLE , NOVEL THERAPEUTIC APPROACH TARGETING THE HIF-HRE SYSTEM IN THE KIDNEYCAROTID BODY SENSORY DISCHARGE AND GLOMUS CELL HIF-1a ARE REGULATED BY A COMMON OXYGEN SENSOR; IMPACT OF REACTIVE OXYGEN SPECIES ON THE EXPRESSION OF ADHESION MOLECULES IN VIVO; MINI SENSING CHIP FOR POINT-OF-CARE ACUTE MYOCARDIAL INFARCTION DIAGNOSIS UTILIZING MICRO-ELECTRO-MECHANICAL SYSTEM AND NANO-TECHNOLOGY; A CHEMICAL BIOSYNTHESIS DESIGN FOR AN ANTIATHEROSCLEROSIS DRUG BY ACYCLIC TOCOPHEROL INTERMEDIATE ANALOGUE BASED ON "ISOPRENOMICS"; ZYMOGEN PROTEIN C CONCENTRATE FOR SAFER HETEROZYGOTE SURGERY, "I AM A GUINEA PIG!" , STEADY STATE REDOX LEVELS IN CYTOCHROME OXIDASE: RELEVANCE FOR IN VIVO NEAR INFRARED SPECTROSCOPY (NIRS)BICUCULLINE-INDUCED SEIZURES: A CHALLENGE FOR OPTICAL AND BIOCHEMICAL MODELING OF THE CYTOCHROME OXIDASE CU A NIRS SIGNAL; A METHOD TO CALCULATE ARTERIAL AND VENOUS SATURATION FROM NEAR INFRARED SPECTROSCOPY (NIRS); DEVELOPMENT OF A DYNAMIC TEST PHANTOM FOR OPTICAL TOPOGRAPHY; NUMERICAL SIMULATION OF OXYGEN TRANSPORT IN CEREBRAL TISSUE; NON-INVASIVE ESTIMATION OF METABOLIC FLUX AND BLOOD FLOW IN WORKING MUSCLE: EFFECT OF BLOOD-TISSUE DISTRIBUTION , OXYGEN EXTRACTION INDEX MEASURED BY NEAR INFRAREDSPECTROSCOPY - A PARAMETER FOR MONITORING TISSUEOXYGENATION?NON-INVASIVE MEASUREMENT OF THE SUPERFICIAL CORTICAL OXYGEN PARTIAL PRESSURE; ONE SENSOR FITS ALL - A NEW APPROACH IN MONITORING BRAIN PHYSIOLOGY; EVALUATION OF NIRS DATA BASED ON THEORETICAL ANALYSIS OF OXYGEN TRANSPORT TO CEREBRAL TISSUE; MYOCARDIAL CAPILLARY NET AND BLOOD CONSTITUENTS IN STREPTOZOTOCIN (STZ)- INDUCED DIABETIC RATS; EFFECTS OF PROINSULIN C-PEPTIDE ON OXYGEN TRANSPORT, UPTAKE AND UTILIZATION IN INSULINOPENIC DIABETIC SUBJECTS - A REVIEW , REDUCED OXYGENATION IN DIABETIC RAT KIDNEYS MEASURED BY T2* WEIGHTED MAGNETIC RESONANCE MICRO-IMAGING , Air and fire : Carl Wilhelm Scheele, Torbern Bergman, the Royal Society of Sciences and the discovery of oxygen in Uppsala in 1772 , Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation , Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions , Nitrite-induced improved blood circulation associated with an increase in a pool of RBN-NO with NO bioactivity , The control of oxidative phosphorylation in the adrenal gland (Y1) cell line , Replication of murine mitochondrial DNA following irradiation , Effects of anesthesia on brain mitochondrial function, blood flow, ionic and electrical activity monitored in vivo , The influence of flow redistribution on working rat muscle oxygenation , Heterogeneity of capillary spacing in the hypertrophied plantaris muscle from young-adult and old rats , Microvascularity of the lumbar erector spinae muscle during sustained prone trunk extension test , Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle , Novel therapeutic approach targeting the HIF-HRE system in the kidney , Carotid body sensory discharge and glomus cell HIF-1[alpha] are regulated by a common oxygen sensor , Impact of reactive oxygen species on the expression of adhesion molecules in vivo , Mini sensing chip for point-of-care acute myocardial infarction diagnosis utilizing micro-electro-mechanical system and nano-technology , A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics" , Zymogen protein C concentrate for safer heterozygote surgery, "I am a guinea pig!" , Steady state redox levels in cytochrome oxidase : relevance for in vivo near infrared spectroscopy (NIRS) , Bicuculline-induced seizures : a challenge for optical and biochemical modeling of the cytochrome oxidase CUa NIRS signal , A method to calculate arterial and venous saturation from near infrared spectroscopy (NIRS) , Development of a dynamic test phantom for optical topography , Numerical simulation of oxygen transport in cerebral tissue , Non-invasive estimation of metabolic flux and blood flow in working muscle : effect of blood-tissue distribution , Oxygen extraction index measured by near infrared spectroscopy : a parameter for monitoring tissue oxygenation? , Non-invasive measurement of the superficial cortical oxygen partial pressure , One sensor fits all : a new approach in monitoring brain physiology , Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue , Myocardial capillary net and blood constituents in streptozotocin (STZ- )-induced diabetic rats , Effects of proinsulin C-peptide on oxygen transport uptake and utilization in insulinopenic diabetic subjects : a review , Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging , Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney , Iodinated contrast media decrease renomedullary blood flow : a possible cause of contrast media-induced nephropathy , C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats , Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents , Prognostic potential of the pre-therapeutic tumor oxygenation status , Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials , The relationship between vascular oxygen distribution and tissue oxygenation , Intraoperative measurement of colonic oxygenation during bowel resection , Quantifying tumour hypoxia by PET imaging : a theoretical analysis , New measurements for assessment of impaired cerebral autoregulation using near-infrared spectroscopy , Single shot T₁p magnetic resonance imaging of metabolically generated water in vivo , Brain tissue oxygen consumption and supply induced by neural activation : determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex , Brain oxygen balance under various experimental pathophysiological conditions , Ketones suppress brain glucose consumption , False positives in functional near-infrared topography , Relationship between brain tissue haemodynamics, oxygenation, and metabolism in the healthy human adult brain during hyperoxia and hypercapnea , Use of a Codman microsensor intracranial pressure probe : effects on near infrared spectroscopy measurements and cerebral hemodynamics in rats , Effect of severe hypoxia on prefrontal cortex and muscle oxygenation responses at rest and during exhaustive exercise

Additional Edition: ISBN 9780387859972

Additional Edition: Buchausg. u.d.T. Oxygen transport to tissue ; 30 New York, NY : Springer, 2009 ISBN 9780387859972

Language: English

Subjects: Biology

Keywords: Sauerstofftransport ; Gewebestoffwechsel ; Sauerstofftransport ; Gewebestoffwechsel ; Konferenzschrift

DOI: 10.1007/978-0-387-85998-9

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Format: Online-Ressource (digital)

ISBN: 9780387775746

Series Statement: Advances in Experimental Medicine and Biology 624

Content: The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment

Note: Includes bibliographical references and index , CONTENTS; 1. SUNLIGHT, UV-RADIATION, VITAMIN D AND SKIN CANCER: HOW MUCH SUNLIGHT DO WE NEED?; Abstract; Prehistorical and Historic Perspectives; Photoproduction of Vitamin D3; Factors Controlling Cutaneous Vitamin D Synthesis; Sources and Metabolism of Vitamin D; Role of Vitamin D in the Prevention of Chronic Diseases; Vitamin D Deficiency Pandemic; Sunlight, Vitamin D and the Skin Cancer Conundrum; Conclusion; 2. SOLAR ULTRAVIOLET IRRADIANCE AND CANCER INCIDENCE AND MORTALITY; Introduction; Cancer; Other Diseases for Which Solar UVB and Vitamin D Are Beneficial/Protective , Summary and Conclusion3. VITAMIN D STATUS AND CANCER INCIDENCE AND MORTALITY; Introduction; Ecologic Studies of Sun Exposure; Case-Control and Cohort Studies of Sun Exposure; Prospective Studies of Circulating 25(OH)vitamin D and Cancer Risk; Studies of Vitamin D Intake; Randomized Trial of Vitamin D Intake and Colorectal Cancer; Solar Radiation, Vitamin D and Survival Rate of Colon Cancer; Vitamin D and Cancer Rates in United States Black Men; Synthesis of Evidence Regarding Sun Exposure, Vitamin D and Cancer Incidence and Mortality; Implications for Future Research , 4. SUN EXPOSURE AND CANCER SURVIVAL IN NORWAY: CHANGES IN THE RISK OF DEATH WITH SEASON OF DIAGNOSIS AND LATITUDEAbstract; Introduction; Materials and Methods; Dependency of Survival on Season of Diagnosis; Dependency of Survival on Residential Region; Discussion; Conclusions; 5. OPTIMAL SERUM 25-HYDROXYVITAMIN D LEVELS FOR MULTIPLE HEALTH OUTCOMES; Abstract; Introduction; 25(OH)D Levels and Bone Health; 25(OH)D and Lower Extremity Function; 25(OH)D and Dental Health; 25(OH)D and Cancer Incidence and Mortality; Vitamin D Intake Needed to Achieve Optimal 25(OH)D Levels , Adding Calcium to Vitamin DDiscussion; 6. ULTRAVIOLET EXPOSURE SCENARIOS: RISKS OF ERYTHEMA FROM RECOMMENDATIONS ON CUTANEOUS VITAMIN D SYNTHESIS; Abstract; Introduction; Differences between Vitamin D Synthesis and Erythema; Implications for UV Exposure; Assessing the Erythema Risks of Exposures for Vitamin D Synthesis; Public Health and Personal Choice; 7. AT WHAT TIME SHOULD ONE GO OUT IN THE SUN?; Abstract; Introduction; Methods; Results and Discussion; 8. EPIDEMIOLOGY OF MELANOMA AND NONMELANOMA SKIN CANCER-THE ROLE OF SUNLIGHT; Abstract; Introduction; Nonmelanoma Skin Cancer , Sun Exposure and Nonmelanoma Skin CancerMelanoma; Sun Exposure and Melanoma; 9. ULTRAVIOLET RADIATION AND MALIGNANT MELANOMA; Abstract; Introduction; Does UV Radiation Induce CMM?; Materials and Methods; Results and Discussion; 10. SOLAR UV EXPOSURE AND MORTALITY FROM SKIN TUMORS; Abstract; Introduction; Observed Relationships for Nonmelanoma Skin Cancer; Observed Relationships for Cutaneous Melanoma; Potential Mechanisms; Conclusions; 11. HEALTH INITIATIVES FOR THE PREVENTION OF SKIN CANCER; Introduction; Prevention of Skin Cancer; Balanced Messages (Concerning Vitamin D); Conclusion , 12. SUNSCREENS

Additional Edition: ISBN 9780387775739

Additional Edition: Erscheint auch als Druck-Ausgabe Sunlight, vitamin D, and skin cancer New York, NY : Springer Science+Business Media [u.a.], 2008 ISBN 9780387775739

Additional Edition: ISBN 0387775730

Language: English

Subjects: Medicine

Keywords: Hautkrebs ; Vitamin D3 ; Sonnenstrahlung ; Aufsatzsammlung

DOI: 10.1007/978-0-387-77574-6

URL: Volltext

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Format: Online-Ressource (digital)

ISBN: 9780387782256

Series Statement: Advances in Experimental Medicine and Biology 627

Note: Includes bibliographical references and index

Additional Edition: ISBN 9780387782249

Additional Edition: Buchausg. u.d.T. Transgenesis and the management of vector-borne disease Austin, Tex. : Landes Bioscience, 2008 ISBN 9780387782249

Additional Edition: ISBN 0387782249

Language: English

Subjects: Biology , Medicine

Keywords: Insekten ; Krankheitsübertragung ; Transgener Organismus ; Infektionskrankheit ; Prävention

DOI: 10.1007/978-0-387-78225-6

URL: Volltext

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Format: Online-Ressource (digital)

ISBN: 9780387775708

Series Statement: Advances In Experimental Medicine And Biology 625

Note: Includes bibliographical references and index

Additional Edition: ISBN 9780387775692

Additional Edition: Buchausg. u.d.T. Drug targets in kinetoplastid parasites New York, NY : Springer Science+Business Media LLC, 2008 ISBN 9780387775692

Additional Edition: ISBN 0387775692

Language: English

Subjects: Chemistry/Pharmacy , Medicine

Keywords: Leishmania ; Trypanosomen ; Kinetoplastida ; Kinetoplasten-DNS ; Pharmakotherapie ; Antiparasitäres Mittel ; Aufsatzsammlung

DOI: 10.1007/978-0-387-77570-8

URL: Volltext

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UID:

Format: Online-Ressource (digital)

ISBN: 9780387096063

Series Statement: Advances in Experimental Medicine and Biology 638

Content: We visualise developmental biology as the study of progressive changes that occur within cells, tissues and organisms themselves during their life span. A good example of a field of developmental biology in which this concept is encapsulated is that of somitogenesis. The somite was identified as the primordial unit underlying the segmented organisation of vertebrates more than two centuries ago. The spectacular discoveries and achievements in molecular biology in the last fifty years have created a gene-based revolution in both the sorts of questions as well as the approaches one can use in developmental biology today. Largely as a result of this, during the 20th and 21st centuries this simple structure, the somite, has been the focus of a deluge of papers addressing multiple aspects of somite formation and patterning both at the cellular and molecular level. One of the main reasons for such interest in the process of somitogenesis stems from the fact that it is such an exquisitely beautiful example of biology working under strict temporal and spatial control in a reiterative manner that is highly conserved across the vertebrate classes. Our intention is that this book will be of interest to different kinds of scientists, including basic researchers, pathologists, anatomists, teachers and students working in the fields of cell and developmental biology. The nine chapters cover a wide array of topics that endeavour to capture the spirit of this dynamic and ever-expanding discipline by integrating both contemporary research with the classical embryological literature that concentrated on descriptions of morphological changes in embryos and the interactions of cells and tissues during development. In so doing they encompass the main aspects of somitogenesis across four vertebrate classes (frog, fish, mouse and chick) and the hope is that this will enable readers to acquire an appreciation of this developmental process in all its facets. Each of the different animal models offers alternative strategic approaches (including experimental embryology, genetics and cell biology) to tackle the same process and as such each offers an invaluable and unique insight into different aspects of somitogenesis. The topics described in these chapters cover the generation of somitic tissue during gastrulation, the molecular mechanisms by which the unsegmented pre-somitic mesoderm becomes segmented into somites, the generation of polarity within somites and the means by which the somite is directed to differentiate into a number of different cell derivatives. There are also two chapters devoted to describing the latest developments on relating spontaneous mouse mutations and mutations leading to abnormal vertebral segmentation in man to the molecular mechanisms already identified as being crucial for somite formation in the lower vertebrates. We would like to heartily thank all of the authors that have contributed their time and effort and whose work has made this book possible. Only they know how difficult it has been to conclude a book that we started more than four years ago, initially with another publisher. One year ago the project was cancelled and then re-started again when the people of Landes accepted to publish it. I am especially grateful for the understanding and patience of Cynthia Conomos and Celeste Carlton who have worked tirelessly to ensure that this project reached completion. We made it!

Note: Description based upon print version of record , CONTENTS; 1 FORMATION AND DIFFERENTIATION OF AVIAN SOMITE DERIVATIVES; Abstract; Introduction; Dermomyotome; Sclerotome; Outlook; 2. AVIAN SOMITOGENESIS: TRANSLATING TIME AND SPACE INTO PATTERN; Abstract; Introduction; Epithelialization of the Segmental Plate; The Anterior Posterior Polarization of the Paraxial Mesoderm; Resegmentation of the Somitic Derivatives; Regionalization of Somites and Segmental Plate; Oscillations in Gene Expression Underlying Somitogenesis; Conclusion and Future Considerations; 3. GENETIC ANALYSIS OF SOMITE FORMATION IN LABORATORY FISH MODELS; Abstract; Introduction , Genetically Dissecting the Clock in Zebrafish: The Delta/Notch Somitogenesis MutantsDissecting the Wave Front in Zebrafish: FGF Signalling and Tbx24; Other Pathways Implicated in Somitogenesis; Medaka: A Model Complementary to Zebrafish; Somite Formation in the Teleost Medaka; Medaka Somitogenesis Mutants; Medaka Somite Mutants with PSM Prepatterning Defects; Medaka Mutants with Defective Somite Polarity; Conclusions and Outlook; 4. OLD WARES AND NEW: FIVE DECADES OF INVESTIGATION OF SOMITOGENESIS IN XENOPUS LAEVIS; Abstract; Introduction; Structure of the PSM , Morphological Descriptions of Segmentation in XenopusA Comparison of Xenopus Segmentation with that of Amniote Vertebrates; What Controls Where the Somitic Furrow Forms?; Evidence for Segmental Prepatterning of the PSM; Cycling Genes--Evidence of a "Clock"?; Embryological Insights into the Nature of the "Wavefront"; The Molecular Nature of the Wavefront; What are the Morphomechanical Mechanisms Required for Somite Separation?; Ena/VASP; Conclusion; 5. ROLE OF DELTA-LIKE-3 IN MAMMALIAN SOMITOGENESIS AND VERTEBRAL COLUMN FORMATION; Abstract; Introduction; Somitogenesis , The Notch Signalling PathwayNotch Signalling and Somite Formation; DII1 and DII3 Perform Different Functions during Somitogenesis in Mammals; Dll3 Conclusions and the Future; 6. MESP-FAMILY GENES ARE REQUIRED FOR SEGMENTAL PATTERNING AND SEGMENTAL BORDER FORMATION; Abstract; Introduction; Background of Mesp1 and Mesp2; Function of Mesp2 during Somitogenesis; Mesp2 Is also Involved in the Segment Border Formation; Regulation of Mesp2 Expression during Somitogenesis; Functional Redundancy between Mesp1 and Mesp2; Mesp Genes in the Other Vertebrates; Perspective , 7. BHLH PROTEINS AND THEIR ROLE IN SOMITOGENESISAbstract; Introduction; The Hairy/E(Spl) Related Factors; pMesogeninl Family: pMesogeninl, Mespo and cMespo; The Mesp Family: Mesp, Meso and Thylacine; Paraxis; Myogenic Regulatory Factors (MRFs); bHLH Factors Involved in the Control of Myogenesis; Conclusions; 8. MOUSE MUTATIONS DISRUPTING SOMITOGENESIS AND VERTEBRAL PATTERNING; Introduction; Notch Signaling Pathway; Canonical Wnt Signaling Pathway; Noncanonical Wnt Signaling Pathway; FGF (Fibroblast Growth Factor) Signaling Pathway , RA (Retinoic Acid) Signaling Pathway ...................................

Additional Edition: ISBN 9780387096056

Additional Edition: Buchausg. u.d.T. Babič, Vasilij M., 1930 - The boundary-layer method in diffraction problems Berlin : Springer, 1979 ISBN 3540096051

Additional Edition: ISBN 0387096051

Language: English

Subjects: Physics

Keywords: Beugung ; Randwertproblem ; Beugung ; Randwertproblem

DOI: 10.1007/978-0-387-09606-3

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover