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  • Berlin  (5)
  • HU Berlin  (5)
  • GB Glienicke/Nordbahn
  • Bibliothek Lübbenau - Vetschau
  • SB Großräschen
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  • 2020-2024  (5)
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  • Berlin  (5)
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  • HU Berlin  (5)
  • GB Glienicke/Nordbahn
  • Bibliothek Lübbenau - Vetschau
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  • SRB Frankfurt/Oder
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  • 2020-2024  (5)
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  • 1
    Online-Ressource
    Online-Ressource
    Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans (2020)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_22095
    Umfang: 1 Online-Ressource (23 Seiten)
    Inhalt: Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in maintaining health, especially during ageing. Even neurodegeneration, which is part of the natural ageing process, as well as the foundation of ageing-related neurodegenerative disorders like Alzheimer’s and Parkinson’s disease (PD), was successfully targeted by MD. In this regard, olive oil and its polyphenolic constituents have received increasing attention in the last years. Thus, this study focuses on two main olive oil polyphenols, hydroxytyrosol (HT) and oleuropein aglycone (OLE), and their effects on ageing symptoms with special attention to PD. In order to avoid long-lasting, expensive, and ethically controversial experiments, the established invertebrate model organism Caenorhabditis elegans was used to test HT and OLE treatments. Interestingly, both polyphenols were able to increase the survival after heat stress, but only HT could prolong the lifespan in unstressed conditions. Furthermore, in aged worms, HT and OLE caused improvements of locomotive behavior and the attenuation of autofluorescence as a marker for ageing. In addition, by using three different C. elegans PD models, HT and OLE were shown i) to enhance locomotion in worms suffering from α-synuclein-expression in muscles or rotenone exposure, ii) to reduce α-synuclein accumulation in muscles cells, and iii) to prevent neurodegeneration in α-synuclein-containing dopaminergic neurons. Hormesis, antioxidative capacities and an activity-boost of the proteasome & phase II detoxifying enzymes are discussed as potential underlying causes for these beneficial effects. Further biological and medical trials are indicated to assess the full potential of HT and OLE and to uncover their mode of action.
    Inhalt: Peer Reviewed
    In: Basel : Molecular Diversity Preservation International, 21,7
    Sprache: Englisch
    DOI: 10.18452/21358
    DOI: 10.3390/ijms21072588
    URN: urn:nbn:de:kobv:11-110-18452/22095-5
    URL: Volltext  (kostenfrei)
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Online-Ressource
    Volltext
    HU Berlin
  • 2
    Online-Ressource
    Online-Ressource
    Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv. (2021)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_23593
    Umfang: 1 Online-Ressource (18 Seiten)
    Inhalt: To uncover potential anti-aging capacities of Traditional Chinese Medicine (TCM), the nematode Caenorhabditis elegans was used to investigate the effects of Eucommia ulmoides and Cuscuta chinensis extracts, selected by screening seven TCM extracts, on different healthspan parameters. Nematodes exposed to E. ulmoides and C. chinensis extracts, starting at the young adult stage, exhibited prolonged lifespan and increased survival after heat stress as well as upon exposure to the pathogenic bacterium Photorhabdus luminescens, whereby the survival benefits were monitored after stress initiation at different adult stages. However, only C. chinensis had the ability to enhance physical fitness: the swimming behavior and the pharyngeal pumping rate of C. elegans were improved at day 7 and especially at day 12 of adulthood. Finally, monitoring the red fluorescence of aged worms revealed that only C. chinensis extracts caused suppression of intestinal autofluorescence, a known marker of aging. The results underline the different modes of action of the tested plants extracts. E. ulmoides improved specifically the physiological fitness by increasing the survival probability of C. elegans after stress, while C. chinensis seems to be an overall healthspan enhancer, reflected in the suppressed autofluorescence, with beneficial effects on physical as well as physiological fitness. The C. chinensis effects may be hormetic: this is supported by increased gene expression of hsp-16.1 and by trend, also of hsp-12.6.
    Inhalt: Peer Reviewed
    Anmerkung: This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
    In: Lausanne : Frontiers Media, 12
    Sprache: Englisch
    DOI: 10.3389/fphar.2021.604435
    DOI: 10.18452/22920
    URN: urn:nbn:de:kobv:11-110-18452/23593-7
    URL: Volltext  (kostenfrei)
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Online-Ressource
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    HU Berlin
  • 3
    Online-Ressource
    Online-Ressource
    Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models (2020)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_26008
    Umfang: 1 Online-Ressource (22 Seiten)
    Inhalt: Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders. In this regard, olive oil and its biophenolic constituents like hydroxytyrosol (HT) have received growing attention in the past years. Thus, in the current study we test the health-promoting effects of two hydroxytyrosol preparations, pure HT and Hidrox® (HD), which is hydroxytyrosol in its “natural” environment, in the established invertebrate model organism Caenorhabditis elegans. HD exposure led to much stronger beneficial locomotion effects in wild type worms compared to HT in the same concentration. Consistent to this finding, in OW13 worms, a PD-model characterized by α-synuclein expression in muscles, HD exhibited a significant higher effect on α-synuclein accumulation and swim performance than HT, an effect partly confirmed also in swim assays with the UA44 strain, which features α-synuclein expression in DA-neurons. Interestingly, beneficial effects of HD and HT treatment with similar strength were detected in the lifespan and autofluorescence of wild-type nematodes, in the neuronal health of UA44 worms as well as in the locomotion of rotenone-induced PD-model. Thus, the hypothesis that HD features higher healthspan-promoting abilities than HT was at least partly confirmed. Our study demonstrates that HD polyphenolic extract treatment has the potential to partly prevent or even treat ageing-related neurodegenerative diseases and ageing itself. Future investigations including mammalian models and human clinical trials are needed to uncover the full potential of these olive compounds.
    Inhalt: Peer Reviewed
    In: Basel : Molecular Diversity Preservation International, 21,11
    Sprache: Englisch
    DOI: 10.3390/ijms21113893
    DOI: 10.18452/25315
    URN: urn:nbn:de:kobv:11-110-18452/26008-0
    URL: Volltext  (kostenfrei)
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    HU Berlin
  • 4
    Online-Ressource
    Online-Ressource
    Identification of a Hydroxygallic Acid Derivative, Zingibroside R1 and a Sterol Lipid as Potential Active Ingredients of Cuscuta chinensis Extract That Has Neuroprotective and Antioxidant Effects in Aged Caenorhabditis elegans (2022)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_26579
    Umfang: 1 Online-Ressource (32 Seiten)
    Inhalt: We examined the effects of the extracts from two traditional Chinese medicine plants, Cuscuta chinensis and Eucommia ulmoides, on the healthspan of the model organism Caenorhabditis elegans. C. chinensis increased the short-term memory and the mechanosensory response of aged C. elegans. Furthermore, both extracts improved the resistance towards oxidative stress, and decreased the intracellular level of reactive oxygen species. Chemical analyses of the extracts revealed the presence of several bioactive compounds such as chlorogenic acid, cinnamic acid, and quercetin. A fraction from the C. chinensis extract enriched in zingibroside R1 improved the lifespan, the survival after heat stress, and the locomotion in a manner similar to the full C. chinensis extract. Thus, zingibroside R1 could be (partly) responsible for the observed health benefits of C. chinensis. Furthermore, a hydroxygallic acid derivative and the sterol lipid 4-alpha-formyl-stigmasta-7,24(241)-dien-3-beta-ol are abundantly present in the C. chinensis extract and its most bioactive fraction, but hardly in E. ulmoides, making them good candidates to explain the overall healthspan benefits of C. chinensis compared to the specific positive effects on stress resistance by E. ulmoides. Our findings highlight the overall anti-aging effects of C. chinensis in C. elegans and provide first hints about the components responsible for these effects.
    Inhalt: Peer Reviewed
    In: Basel : MDPI, 14,19
    Sprache: Englisch
    DOI: 10.3390/nu14194199
    DOI: 10.18452/25899
    URN: urn:nbn:de:kobv:11-110-18452/26579-6
    URL: Volltext  (kostenfrei)
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    HU Berlin
  • 5
    Online-Ressource
    Online-Ressource
    Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study (2022)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_28682
    Umfang: 1 Online-Ressource (22 Seiten)
    Inhalt: To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn’s disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healthspan markers. Thirteen homologous or closely related genes were selected in the model organism C. elegans for evaluating healthspan after targeted RNAi-mediated knockdown using pathogen resistance, muscle integrity, chemotaxis index and the activity of known longevity and stress response pathways as healthspan reporters. In addition, lifespan was monitored in the RNAi-treated nematodes. RNAi knockdown of yap-1, wwp-1, paxt-1 and several acdh genes resulted in heterogeneous phenotypes regarding muscle integrity, pathogen resistance, chemotactic behaviour, and lifespan. Based on these observations, we hypothesize that their human homologues WWC2, CDKN2AIP and ACADS may play a role in health maintenance in the elderly.
    Inhalt: Peer Reviewed
    In: Dordrecht [u.a.] : Springer Science + Business Media B.V, 23,4, Seiten 431-452
    Sprache: Englisch
    DOI: 10.18452/27895
    DOI: 10.1007/s10522-022-09969-8
    URN: urn:nbn:de:kobv:11-110-18452/28682-6
    URL: Volltext  (kostenfrei)
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    HU Berlin
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