In:
Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 140, No. 4_Supplement ( 2016-10-01), p. 3393-3393
Abstract:
Vocal fold surgery, especially due to cancer treatment, yields reduced voice quality and consequently reduced quality of life for patients. Hence, the development of vocal fold implants, to restore missing vocal fold tissue after surgery, is an urgent clinical need. To achieve this, a rabbit model is applied as a first step. Ex-vivo dynamic experiments were performed on twelve rabbit larynges providing normative phonatory data. The larynges were phonated at sustained phonation for different elongation levels at varying subglottal pressures. Laryngeal vibrations, airflow, and acoustics were recorded. Subsequently, for each larynx, a defined area of one vocal fold was resected, simulating the surgical intervention, and were phonated again with the same stimulations. The untreated larynges showed expected behavior regarding flow-pressure relation, acoustics and dynamics. In contrast, the phonatory quality of the resected larynges was significantly reduced showing, as expected, highly disturbed dynamics and acoustics. Parallel, vocal fold fibroblasts were isolated from rabbit larynges and cultured. These cells were treated with superparamagnetic iron oxide nanoparticles enabling their magnetic control. By magnetic tissue engineering three dimensional structures were designed. Next, the applicability of this tissue engineered implant will be tested in the dynamic ex-vivo rabbit model to compare the phonatory outcome.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2016
detail.hit.zdb_id:
1461063-2
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