Umfang:
Online-Ressource
,
v.: digital
Ausgabe:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9781402056888
Serie:
Subcellular Biochemistry 42
Inhalt:
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Inhalt:
"In ""Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy"", a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the ""COX-2 controversy"" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer's disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents."
Anmerkung:
Description based upon print version of record
,
Front Matter; Anti-Inflammatory Drugs in the 21st Century; Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus; Obesity, Inflammation, and Vascular Disease; Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer; Role of COX-2 in Inflammatory and Degenerative Brain Diseases; Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors; COX-2 Inhibitors And Cardiovascular Risk; A Biological Rationale for the Cardiotoxic Effects of Rofecoxib; Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade; Strategies for Colon Cancer Prevention
,
NSAIDs for the Chemoprevention of Alzheimer's DiseaseInflammation in parkinson's disease; Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases; Nutritional Intervention in Brain Aging; Back Matter
,
Electronic reproduction; Available via World Wide Web
Weitere Ausg.:
ISBN 9781402056871
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Chronische Krankheit
;
Pathogenese
;
Entzündung
DOI:
10.1007/1-4020-5688-5
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