In:
International Journal of Cancer, Wiley, Vol. 134, No. 1 ( 2014-01), p. 235-243
Abstract:
What's new? Therapeutic induction of senescence (TIS) has emerged as a promising cancer treatment strategy with the potential to overcome therapy resistance due to the ability of tumor cells to evade apoptosis. Although senescent cells undergo a permanent cell cycle arrest, they remain metabolically active in vivo , making combination approaches to eliminate them urgently needed. This study provides a proof‐of‐concept that, despite the profoundly altered phenotype of senescent tumor cells, oncolytic viruses are able to hijack cancer cells after TIS, leading to a destruction of tumor cells. These observations open up a new research field at the crossroads between TIS and virotherapy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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