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The relationship between nutrition and the development of chronic diseases including metabolic syndrome, diabetes mellitus, cancer and cardiovascular disease has been well studied. On the other hand, changes in the GH-IGF-1 axis in association with nutrition-related diseases have been reported. The interplay between GH, total IGF-1 and different inhibitory and stimulatory kinds of IGF-1 binding proteins (IGFBPs) results in IGF-1 bioactivity, the ability of IGF-1 to induce phosphorylation of its receptor and consequently its signaling. Moreover, IGF-1 bioactivity is sufficient to reflect any change in the GH-IGF-1 system. Accumulating evidence suggests that both of high protein diet, characterized by increased glucagon secretion, and insulin-induced hypoglycemia increase mortality rate and the mechanisms are unclear. However both of glucagon and insulin-induced hypoglycemia are potent stimuli of GH secretion. The aim of the current study was to identify the impact of glucagon and insulin-induced hypoglycemia on IGF-1 bioactivity as pos…
Anmerkung:
Dissertation Universität Potsdam 2015
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Sarem, Zeinab, 1982 - Regulation of IGF-1 bioactivity by dietary hormones Potsdam, 2015
Sprache:
Englisch
Schlagwort(e):
Hochschulschrift
URN:
urn:nbn:de:kobv:517-opus4-82198
URL:
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URL:
https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-82198
URL:
https://d-nb.info/1218399732/34
Mehr zum Autor:
Pfeiffer, Andreas 1953-
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