Umfang:
Online-Ressource (VII, 213 p. 21 illus., 19 illus. in color, online resource)
ISBN:
9781461473510
Serie:
SpringerLink
Inhalt:
Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases. Second, it is unique with respect to scope of the discussion of the unusual characteristics of the immune response which occurs in these patients. Third, it includes knowledge being gained from translational research conducted through clinical trials at several Medical Schools in the United States. Not only is this research providing infor
Anmerkung:
Description based upon print version of record
,
Introduction; Contents; Immunopathology of COPD; Anatomical Evidence; Functional Evidence; Dendritic Cells; Mast Cells; Eosinophils; Neutrophils and Macrophages; T Cells; Lymphoid Follicles and B Cells; Cytokines; Antibodies; Adaptive Immunity in Emphysema; Synopsis; References; Monocyte Populations Which Participate in Chronic Lung Inflammation; Introduction; Monocyte Development; Monocyte Subpopulations; Monocyte Traffic to the Lung; Macrophages; Microbial Pattern Recognition Receptors; Classically Activated Macrophages; Alternatively Activated Macrophages
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Monocyte Subtype and Bacterial InfectionMacrophage Subtypes and Bacterial Infection; Monocyte and Macrophage Subtypes in Viral Infection; Monocyte and Macrophage Subtypes in Parasitic Infection; Helminthic Infections; Nematodes; Trematodes; Cestodes; Protozoan Infections; Monocyte and Macrophage Subtypes in Fungal Infections; Interstitial Lung Diseases; Chronic Obstructive Pulmonary Disease; Asthma; Cystic Fibrosis; Atherosclerosis; Rheumatoid Arthritis; References; Neutrophil Inflammation in COPD; Introduction: Role of Neutrophils in COPD; Neutrophil Basics; Neutrophil Activation
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Neutrophil Chemoattractants in COPDRecruitment of Neutrophils to the Lung; Neutrophil Killing; Neutrophil Apoptosis; Neutrophil Phenotypes; Systemic Inflammation and Circulating Neutrophil Phenotypes; Neutrophils in Disease Progression and Acute Exacerbations in COPD; Potential Therapeutics in the Treatment of COPD; Conclusion; References; Role of Epithelial Cells in Chronic Inflammatory Lung Disease; Introduction; Clinical Consequences and Airway Pathology; Airway Mucus and Mucins; Epithelial TLRs as Mediators of Airway Inflammation; Neutrophil Elastase in the Airways
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Control of Airway InflammationInterleukin-10; Transforming Growth Factor-β; Peroxisome Proliferator Activating Receptor-γ; MUC1 Mucin; Anti-Inflammatory Role of MUC1 in Airway Epithelia; Regulation of MUC1 Expression by TNF-α; A Proposed Model for the Anti-Inflammatory Role of MUC1 in the Airways; MUC1 Mucin and Chronic Inflammatory Lung Disease; Summary and Conclusions; References; The Relationship Between Oxidative Stress Responses and Lung Inflammation with Cigarette Smoking; Introduction; Cigarette Smoke Composition; Reactive Oxygen Species (ROS); Acrolein; Cadmium
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Polycyclic Aromatic HydrocarbonsNicotine; Antioxidant Defense Systems Involved in the Response to Cigarette Smoke; Nrf2/Keap; Heat Shock Proteins (HSP); Molecular Mechanisms of Oxidant Stress Induced Inflammation; Mitogen Activated Protein Kinases (MAPK); Nuclear Factor Kappa B (NF-κB); AP-1; Histone Deacetylases (HDAC); The Unfolded Protein Response (UPR); Variations in Antioxidant Gene Expression and Susceptibility to Lung Inflammation; Conclusion; References; Autoimmune Mechanisms Contributing to Chronic Obstructive Pulmonary Disease; Summary
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Distinguishing COPD Subsets: Emphysema Versus Chronic Bronchitis
Weitere Ausg.:
ISBN 9781461473503
Weitere Ausg.:
Druckausg. Smoking and lung inflammation New York, NY : Springer, 2013 ISBN 9781461473503
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Lungenentzündung
;
Rauchen
;
Aufsatzsammlung
DOI:
10.1007/978-1-4614-7351-0
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