Kooperativer Bibliotheksverbund

UID:

Umfang: 1 Online-Ressource (XVIII, 679 p. 13 illus).

Ausgabe: 1st ed. 2023

ISBN: 978-1-4842-9315-7

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-1-4842-9314-0

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-1-4842-9316-4

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-1-4842-9317-1

Sprache: Englisch

DOI: 10.1007/978-1-4842-9315-7

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Umfang: 1 Online-Ressource (xxxiii, 702 Seiten) : , 225 Illustrationen, 219 in Farbe.

ISBN: 978-3-031-27077-2

Serie: Lecture notes in computer science 13833

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-27076-5

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-27078-9

Sprache: Englisch

Schlagwort(e): Multimedia ; Konferenzschrift

DOI: 10.1007/978-3-031-27077-2

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Umfang: 1 Online-Ressource (xxxiii, 770 Seiten) : , 262 Illustrationen, 246 in Farbe.

ISBN: 978-3-031-27818-1

Serie: Lecture notes in computer science 13834

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-27817-4

Weitere Ausg.: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-27819-8

Sprache: Englisch

Schlagwort(e): Multimedia ; Konferenzschrift

DOI: 10.1007/978-3-031-27818-1

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Umfang: 1 online resource (xi, 280 pages) : , digital, PDF file(s).

ISBN: 9780511613913 (ebook)

Inhalt: The path adolescents take from childhood to adulthood is a product of social, economic, political, and technological forces. These forces may facilitate youth's preparation to become healthy adults, or they may leave youth unprepared for adulthood. Knowledgeable projections are vital in shaping the agenda for research; for alerting educators, policy makers, and practitioners to new issues; and for formulating thoughtful responses to emerging dilemmas. This book focuses upon the future of adolescence in postindustrial societies. The authors identify some ominous societal changes that will affect youth: unstable job markets, competition for public resources due to an aging population, and widening income gaps between 'information workers' and low-skill workers. But they also observe opportunities created by information technology, innovations in health service delivery and criminal-justice rehabilitation, and the resourcefulness of a new generation. This volume examines these and other macro-structural changes that will impact adolescents' lives and their futures as adults.

Anmerkung: Title from publisher's bibliographic system (viewed on 05 Oct 2015). , Macrostructural trends and the reshaping of adolescence / , Youth in aging societies / , Transition from school to work / , Criminal justice in the lives of American adolescents: choosing the future / , Adolescent health care in the United States: implications and projections for the new millennium / , Youth and information technology / , Social space, the final frontier: adolescents on the Internet / , Approaching policy for adolescent development in the twenty-first century /

Weitere Ausg.: Print version: ISBN 9780521814805

Sprache: Englisch

URL: https://doi.org/10.1017/CBO9780511613913

URL: Volltext  (lizenzpflichtig)

UID:

Umfang: 1 online resource (XII, 374 p. 104 illus., 56 illus. in color.)

Ausgabe: 2nd ed. 2012.

ISBN: 1-61779-965-3

Serie: Methods in Molecular Biology, 910

Inhalt: Recent advances in drug discovery have been rapid.  The second edition of  Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter,  detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition  seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Anmerkung: Bibliographic Level Mode of Issuance: Monograph , English

Weitere Ausg.: ISBN 1-61779-964-5

Sprache: Englisch

DOI: 10.1007/978-1-61779-965-5

UID:

Umfang: 1 online resource (X, 236 p. 45 illus., 27 illus. in color.)

Ausgabe: 1st ed. 2020.

ISBN: 1-4939-9837-4

Serie: Methods in Molecular Biology, 2066

Inhalt: This volume provides readers with a historical foundation in standard techniques and a comprehensive update on the latest methods used in making gene-modified mice. The chapters in this book cover topics such as pronuclear microinjection in one-cell embryos; embryo transfer surgery; nuclear transfer and cloning; blastocyst microinjection; and cryobanking and recovery of genetically modified mice. Importantly, there are chapters devoted to the latest application of CRISPR technology, as well as the establishment of induced pluripotent stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Transgenic Mouse: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field. .

Anmerkung: The History of Transgenesis -- Pronuclear Microinjection of One-Cell Embryos -- Integrase-Mediated Targeted Transgenics through Pronuclear Microinjection -- In Vivo Validation of CRISPR Reagents in Pre-Implantation Mouse Embryos -- Targeted Mutations in the Mouse via Embryonic Stem Cells -- Blastocyst Microinjection with Embryonic Stem Cells -- Generation of Large Fragment Knock-In Mouse Models by Microinjecting into 2-Cell Stage Embryos -- Embryo Transfer Surgery -- Non-Surgical Embryo Transfer Protocol for use with the NSET™ Device -- Nuclear Transfer and Cloning -- Sperm-Mediated Genetic Modifications -- Genotyping Genetically Modified (GM) Mice -- Nomenclature: Naming Your Gene-Modified Mouse -- Breeding Strategies for Genetically Modified Mice -- Strategies for Behaviorally Phenotyping the Transgenic Mouse -- Cryobanking and Recovery of Genetically Modified Mice -- Simple Transportation of Genetically Engineered Mice via Cold Storage Techniques -- Reprogramming of Primary Human Cells to Induced Pluripotent Stem Cells using Sendai Virus.

Weitere Ausg.: ISBN 1-4939-9836-6

Sprache: Englisch

DOI: 10.1007/978-1-4939-9837-1

UID:

Umfang: 1 online resource (XI, 324 p. 63 illus., 54 illus. in color.)

Ausgabe: 3rd ed. 2019.

ISBN: 1-4939-9089-6

Serie: Methods in Molecular Biology, 1939

Inhalt: This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Bioinformatics and Drug Discovery, Third Edition is a valuable resource for anyone interested in drug design, including academicians (biologists, informaticists and data scientists, chemists, and biochemists), clinicians, and pharmaceutical scientists.

Anmerkung: Miniaturized Checkerboard Assays to Measure Antibiotic Interactions -- High-Throughput Screening for Drug Combinations -- Post-Processing of Large Bioactivity Data -- How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM) -- A Guide to Dictionary-Based Text Mining -- Leveraging Big Data to Transform Drug Discovery -- How to Prepare a Compound Collection Prior to Virtual Screening -- Building a Quantitative Structure-Property Relationship (QSPR) Model -- Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility Mass Spectrometry (IM-MS) -- A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine -- Omics Data Integration and Analysis for Systems Pharmacology -- Bioinformatics Based Tools and Software in Clinical Research: A New Emerging Area -- Text Mining for Drug Discovery -- Big Data Cohort Extraction for Personalized Statin Treatment and Machine Learning -- Drug Signature Detection Based on L1000 Genomic and Proteomic Big Data -- Drug Effect Prediction by Integrating L1000 Genomic and Proteomic Big Data -- A Bayesian Network Approach to Disease Subtype Discovery.

Weitere Ausg.: ISBN 1-4939-9088-8

Sprache: Englisch

DOI: 10.1007/978-1-4939-9089-4

UID:

Umfang: 1 online resource (327 p.)

Ausgabe: 1st ed.

ISBN: 1-60741-687-5

Anmerkung: Bibliographic Level Mode of Issuance: Monograph , How dyslexic teenagers cope at school : could a new measure be helpful in screening those in difficulty? / , Interest and motivation : a cultural-historical and discursive psychological approach / , Reading fluency and dyslexia : innovative developments in the role of associative learning and repetitive exposure in skill acquisition / , Cultural influences on the learning of science : an African perspective / , Non-linear dynamic modeling of microdevelopmental processes of students' conceptual change in science / , Phonology, discrepancy, instruction and dyslexia : adversaries or allies? / , Dyslexia and loss of the learning dialogue / , Cognitive load theory and instructional design : an outline of the theory and reflections on a need for new directions to cater for individual differences and motivation / , Attitude towards school, motivation, emotions and academic achievement / , Individual differences in attitude to school and social reputation among peers : implications for behavioural adjustment in educational settings / , Dyslexia as a syndrome : don't let 'reading disability' steal the show / , English

Weitere Ausg.: ISBN 1-60692-276-9

Sprache: Englisch

UID:

Umfang: 1 online resource (193 p.)

ISBN: 1-282-45109-X , 9786612451096 , 0-8330-4828-7 , 0-585-24548-7

Inhalt: Coercion--the use of threatened force to induce an adversary to change its behavior--is a critical function of the U.S. military. U.S. forces have recently fought in the Balkans, the Persian Gulf, and the Horn of Africa to compel recalcitrant regimes and warlords to stop repression, abandon weapons programs, permit humanitarian relief, and otherwise modify their actions. Yet despite its overwhelming military might, the United States often fails to coerce successfully. This report examines the phenomenon of coercion and how air power can contribute to its success. Three factors increase the lik

Anmerkung: "MR-1061-AF." , "Project Air Force, Rand". , Cover; Preface; Contents; Figures; Tables; Summary; Acknowledgements; Chapter One - Introduction; Coercion and U.S. National Security Policy; The Role of the USAF; Methodology and Cases Examined; Organization; Part 1. Definitions and Theory; Chapter Two - How to Think About Coercion; Definitions; A Theoretical Starting Point; Thinking about Coercion: a Policymaker's Perspective; Problem One: Limited Relevance; Problem Two: Measurement Pathologies; The Uncertain Meaning of "Success"; Conclusions; Part 2. Successful Coercive Diplomacy: Lessons from the Past , Chapter Three - Explaining Success or Failure: the Historical Record Conditions for Successful Coercion; Escalation Dominance; Threatening to Defeat an Adversary's Strategy; Coercion in Context: Magnifying Third-Party Threats; Common Challenges in Coercive Operations; Intelligence and Estimation Challenges; Misperceptions and Coercion; Credibility Challenges; Feasibility Challenges; Conclusions; Part 3. Coercive Diplomacy Today; Chapter Four - Domestic Constraints on Coercion; Domestic Politics and the Success of Coercive Diplomacy; Constraints and the Democratic System , The Challenge of Obtaining Domestic Support Consequences of Low Support; Sources of Domestic Constraints; Declaratory Policy; Congressional Checks and Balances, and Other Restrictions; The Press; Some Correlates of Public Support; Some Conditions Under Which Support Is Typically High; How an Adversary can Exploit U.S. Domestic Politics; Diminishing the Interests; Tarnishing the Cause and Conduct of the Operation; Dragging Out a Conflict; Imposing Costs; Manipulating Asymmetries in Escalation Preferences; Conclusions; Chapter Five - Coercion and Coalitions , The Advantages of Coalitions for Coercers Limits Imposed by Coalitions; Lack of a Common Agenda; Shared Control; Limits to Escalation; Reduced Credibility; Coalitions and Adversary Counter-Coercion; Conclusions; Chapter Six - Coercing Nonstate Actors: a Challenge for the Future; Types of Missions; Coercing Local Warlords; Coercing State Sponsors; Characteristics of Coercive Operations Against Nonstate Actors; Nonstate Adversaries May Lack Identifiable and Targetable Assets; Inaccurate Intelligence Estimates Are Particularly Common; Nonstate Adversaries May Lack Control over Constituent Elements , Indirect Coercion Is Often Difficult, Unreliable, and Counterproductive Nonstate Actors Are Adept at Exploiting Countermeasures to Coercion; Conclusions; Part 4. Coercion and the U.S. Air Force; Chapter Seven - Implications and Recommendations for the USAF; Air Power and Escalation Dominance; Air Power and Adversary Military Operations; Air Power and the Magnification of Third-Party Threats; Air Power and Common Challenges in Coercive Operations; The Need for Restraint; Appendix A - Cases Examined for this Study; Appendix B - Cases and Conditions for Success , Appendix C - Coercive Attempts and Common Challenges , English

Weitere Ausg.: ISBN 0-8330-2743-3

Sprache: Englisch

UID:

Umfang: 1 online resource (87 p.)

ISBN: 1-282-08159-4 , 9786612081590 , 0-8330-4702-7

Serie: Rand Corporation monograph series

Inhalt: Provides an analytic framework and procedure for the intelligence analysis of irregular warfare (IW) environments that can serve as the basis for IW intelligence curriculum development efforts. Defines IW in terms of two stylized situations: population-centric (such as counterinsurgency) and counterterrorism. Provides a detailed review of IW-relevant defense policy and strategy documents and a list of relevant doctrinal publications.

Anmerkung: "Prepared for the United States Army." , "MG-668-A"--P. [4] of cover. , Cover; Preface; Contents; Figures; Tables; Summary; Acknowledgments; Abbreviations; CHAPTER ONE- Introduction; Background to the Study; Study Aims and Analytic Approach; Organization of This Monograph; CHAPTER TWO- Defining Irregular Warfare; A Review of Recent Efforts to Define Irregular Warfare; Irregular Warfare Operation Types; Irregular Warfare Common Logical Lines of Operation; Chapter Conclusions; CHAPTER THREE- A Framework for Assessing Irregular Warfare; Population-Centric Irregular Warfare Operations; Counterterrorism Operations; Comparison to the Standard IPB Process , Chapter ConclusionsCHAPTER FOUR- Conclusions; APPENDIX A- A Review of Defense Policy, Strategy, and Irregular Warfare; APPENDIX B- Irregular Warfare Analysis Doctrinal References; References , English

Weitere Ausg.: ISBN 0-8330-4322-6

Sprache: Englisch