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  • UB Potsdam  (26)
  • SRB Cottbus
  • Heinrich-Mann-Bibl. Strausberg
  • Hertie School
  • Biology  (26)
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  • 11
    Online Resource
    Online Resource
    New York, NY : Springer
    UID:
    gbv_1651955301
    Format: Online-Ressource (XXI, 394 p. 77 illus., 48 illus. in color, digital)
    ISBN: 9781461446330
    Series Statement: SpringerLink
    Content: Plant development and productivity are negatively regulated by various environmental stresses. Abiotic stress factors such as heat, cold, drought, and salinity represent key elements limiting agricultural productivity worldwide. Thus, developing crop plants with the ability to tolerate abiotic stresses is a critical need which demands modern novel strategies for the thorough understanding of plant response to abiotic stresses. Crop Improvement under Adverse Conditions will serve as a cutting-edge resource for researchers and students alike who are studying plant abiotic stress tolerance and crop improvement. The book presents the latest trends and developments in the field, including the impact of extreme events on salt tolerant forest species of Andaman & Nicobar Islands, the overlapping horizons of salicylic acid in different stresses, and fast and reliable approaches to crop improvement through In Vitro haploid production. Written by renowned experts and featuring useful illustrations and photographs, Crop Improvement under Adverse Conditions is a concise and practical update on plant abiotic stress tolerance and crop improvement.
    Note: Description based upon print version of record , Foreword; Preface; Contents; The Editors; List of Contributors; Chapter-1; The Research, Development, Commercialization, and Adoption of Drought and Stress-Tolerant Crops; 1 The Importance of Stress-Tolerant Crops; 1.1 Background of Stress-Tolerant Crop Genetics; 1.2 Recent Advances at the Molecular Level; 1.3 Research and Development and the Commercialization of New Crop Varieties; 1.4 Roles of the Public Sector and the Private Sector; 2 The Stages of the R&D Process; 2.1 Managing R&D Risks; 2.2 Four Types of Uncertainties; 2.2.1 Technological Uncertainty , 2.2.2 Intellectual Property Uncertainty2.2.3 Regulatory Uncertainty; 2.2.4 Market Uncertainty; 2.3 Sources of Market Uncertainty: Factors Influencing Farmers' Decisions to Adopt Drought- and Stress-Tolerant Crops; 2.3.1 Interaction with Other Complementary Technologies; 2.3.2 Competition with Potential Substitute Technologies; 2.3.3 Appeal to First-Time Adopters of the Technology (Adoption on the 'Extensive' Margin); 2.3.4 The Distribution of Benefits to Adopters of the Technology over time and Different Locations; 2.3.5 Perceptions are More Important than Reality , 3 What is in the Global R&D Pipeline?3.1 Activity at the Earliest Stages of R&D: Trends in Scientific Publications; 3.2 Activity in Early-Stage Development: Patenting Trends; 3.3 Activity in Late-Stage Development: Field Trial Trends; 3.4 Activity at the Regulatory Stage: Regulatory Submissions; 4 Conclusion; References; Chapter-2; Impact of Extreme Events on Salt-Tolerant Forest Species of Andaman and Nicobar Islands (India); 1 Introduction; 2 Adaptations in Mangroves; 2.1 Morphological Adaptations; 2.2 Physiological Adaptations; 2.3 Anatomical Adaptations; 2.4 Reproductive Strategies , 3 Salt Stress Regulation Mechanisms3.1 Salt Exclusion; 3.2 Salt Excretion; 4 Climate Change and Mangroves; 4.1 Temperature; 4.2 CO2 Concentration; 4.3 Precipitation; 4.4 Hurricanes and Storms; 4.5 Effects of Changes in Sea Level; 4.6 Mangrove Adaptations that help them Survive Sea-Level Rise; 4.7 Environmental Factors that Affect Mangrove Response to Sea Level; 4.8 Species Response to Sea-Level Rise; 4.9 Mangroves and Carbon Sequestration; 5 Impact of Extreme Event of Tsunami on the Mangroves of Andaman and Nicobar Islands (ANI), India-A Case Study; References; Chapter-3 , Greenhouse Gases Emission from Rice Paddy Ecosystem and their Management1 Introduction; 2 Emission of Greenhouse Gases (GHGs) from Agriculture; 3 Methane Emission from Rice Cultivation; 4 Nitrous Oxide Emission from Agricultural Soils; 5 Emission of GHGs due to Field-Burning of Crop Residue; 6 Modelling GHG Emission from Agriculture; 7 Mitigation of GHG Emissions from Agriculture; 7.1 Through Sequestration of Carbon in Soils; 7.2 Conservation Agriculture; 7.3 Water Management; 7.4 Direct Seeding of Rice; 7.5 Fertilizer Management; 7.6 Silicate Fertilization; 7.7 Efficient Management of Manure , 8 Crop Improvement for Reducing GHG Emissions , The Research, Development, Commercialization, and Adoption of Drought and Stress Tolerant Crops -- Impact of Extreme Events on Salt Tolerant Forest Species of Andaman & Nicobar Islands (India) -- Greenhouse Gases Emission from Rice Paddy Ecosystem and their Management -- Remote Sensing Applications to Infer Yield of Tea in a Part of Sri Lanka -- Polyamines Contribution to the Improvement of Crop Plants Tolerance to Abiotic Stress -- Overlapping Horizons of Salicylic Acid in Different Stresses -- Genotoxic Stress, DNA Repair and Crop Productivity -- In Vitro Haploid Production - A Fast and Reliable Approach for Crop Improvement -- Production of Abiotic Stress Tolerant Fertile Transgenic Plants using Androgenesis and Genetic Transformation Methods in Cereal Crops -- Plant Diseases - Control and Remedy through Nanotechnology -- Nanobiotechnology: Scope and potential for crop improvement -- Role of Nematode Trapping Fungi for Crop Improvement under Adverse Conditions -- Sugars As Antioxidants in Plants -- Chromium Toxicity and Tolerance in Crop Plants -- Boron Toxicity and Tolerance in Crop Plants -- Arsenic Toxicity in Crop Plants: Approaches for Stress Resistance -- Mechanism of Cadmium Toxicity and Tolerance in Crop Plants.
    Additional Edition: ISBN 9781461446323
    Additional Edition: Buchausg. u.d.T. Crop improvement under adverse conditions New York, NY : Springer, 2013 ISBN 9781461446323
    Language: English
    Subjects: Agriculture, Forestry, Horticulture, Fishery, Domestic Science , Biology
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    Keywords: Pflanzenzüchtung ; Resistenzzüchtung ; Stressresistenz ; Umweltfaktor ; Pflanzenzüchtung ; Resistenzzüchtung ; Stressresistenz ; Umweltfaktor
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 12
    UID:
    gbv_1081590467
    Format: 142 S.
    Series Statement: Senckenberg-Buch 50
    Note: Mit Literaturangaben
    Language: German
    Subjects: Biology
    RVK:
    Keywords: Watt ; Nordwestdeutschland ; Watt ; Aufsatzsammlung
    Author information: Behre, Karl-Ernst 1935-
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  • 13
    Book
    Book
    Amsterdam [u.a.] : Harwood Academic Publ.
    UID:
    gbv_221403248
    Format: XIII, 407 S , Ill., graph., Darst , 25 cm
    ISBN: 905702036X
    Note: Literaturangaben
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Stressresistenz ; Pflanzenphysiologie
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  • 14
    UID:
    gbv_1634383168
    Format: xix, 355 Seiten , Illustrationen
    ISBN: 9781466512405 , 1466512407
    Content: "Designed to serve a multitude section of students and researchers diversified in the field of Life Sciences, Pharmacy, Biotechnology, Microbiology, Biochemistry, and Environmental Sciences, this book addresses the different aspects of instrumentation that hold the key for cutting edge research and innovative application. The authors emphasize techniques encountered both in the practical classes and also in high through put techniques involved in modern era of commercialization and product inventories. It includes illustrated diagrams to explain the principles and theories behind these instruments"--Provided by publisher
    Note: Spiralbindung , Includes bibliographical references and index
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Biowissenschaften ; Instrument ; Biowissenschaften ; Laborgerät
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  • 15
    UID:
    gbv_780357329
    Format: 1 online resource (xiv, 329 pages) , illustrations, charts
    ISBN: 9781780642741 , 9781780642734
    Series Statement: CABI Books
    Content: This book describes the significance of amino acids and their derivatives in plant stress adaptation/tolerance, and presents biotechnological strategies for the manipulation of amino acids and their major derivatives to improve abiotic and abiotic stress tolerance in crop plants. Chapter 1 presents a general introduction on the role of amino acids and their derivatives in plant stress response. The succeeding chapters focus on amino acids and peptides (chapters 2-6), and amines and brassinosteroids (chapters 7-16), and their role in plant stress adaptation. A brief discussion of the prospects for further research (chapter 17) is included. This publication is suitable for scholars and researchers exploring sustainable strategies for crop improvement and abiotic stress tolerance.
    Note: Includes bibliographical references and index. - Title from PDF title page (viewed February 10, 2014) , Contents; Contributors; Preface; Acknowledgements; Abbreviations; PART I: INTRODUCTION; 1 Environmental Change, and Plant Amino Acids and their Derivatives - An Introduction; PART II: AMINO ACIDS AND PEPTIDES, AND PLANT STRESS ADAPTATION; 2 5-Aminolevulinic Acid (5-ALA) - A Multifunctional Amino Acid as a Plant Growth Stimulator and Stress Tolerance Factor; 3 Cysteine - Jack of All Glutathione-based Plant Stress Defence Trades; 4 Amino Acids and Drought Stress in Lotus: Use of Transcriptomics and Plastidic Glutamine Synthetase Mutants for New Insights in Proline Metabolism , 5 Modulation of Proline: Implications in Plant Stress Tolerance and Development6 Target Osmoprotectants for Abiotic Stress Tolerance in Crop Plants - Glycine Betaine and Proline; PART III: AMINES AND BRASSINOSTEROIDS, AND PLANT STRESS ADAPTATION; 7 Polyamines as Indicators and as Modulators of the Abiotic Stress in Plants; 8 Polyamines in Stress Protection - Applications in Agriculture; 9 Functional Role of Polyamines and Polyamine-metabolizing Enzymes during Salinity, Drought and Cold Stresses; 10 Regulatory Role of Polyamines in Growth, Development and Abiotic Stress Tolerance in Plants , 11 Polyamines - Involvement in Plant Stress Tolerance and Adaptation12 Role of Polyamines in Plant-Pathogen Interactions; 13 Role of Polyamines in Stress Management; 14 Polyamines in Plant In Vitro Culture; 15 Betaines and Related Osmoprotectants - Significance in Metabolic Engineering of Plant Stress Resistance; 16 Brassinosteroids' Role for Amino Acids, Peptides and Amines Modulation in Stressed Plants - A Review; PART IV: APPRAISAL AND PERSPECTIVES; 17 Plant Adaptation to Environmental Change, and Significance of Amino Acids and their Derivatives - Appraisal and Perspectives; Index; A; B , CD; E; F; G; H; I; J; L; M; N; O; P; R; S; T; U; V; Y
    Additional Edition: ISBN 9781780642734
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781780642734
    Additional Edition: Druckausg. Plant adaptation to environmental change Wallingford : CABI, 2014 ISBN 9781780642734
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Pflanzen ; Umweltveränderung ; Anpassung ; Aminosäuren ; Electronic books
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  • 16
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    gbv_1659044693
    Format: Online-Ressource (X, 123 p. 27 illus., 26 illus. in color, online resource)
    ISBN: 9783319091235
    Series Statement: SpringerBriefs in Materials
    Content: This book provides a cohesive overview of carbon concentrating mechanism (CCM) of photosynthetic microorganisms such as cyanobacteria and microalgae. This unique mechanism is by far the most spectacular physiological process in algal growth and productivity. Due to this fact, the study of CCM has captivated phycologists, algal molecular and cellular biologists, botanists, agriculturalists, crop growers, and most recently algal biofuel researchers, around the world. In the brief, the authors draw a contextual in-depth overview, on the basis of the latest findings, to develop an account of the core concepts regarding state-of-the-art of CCM. Subsequent chapters use this account to explore carbon concentrating mechanism of cyanobacteria and microalgae. They highlight the concise summaries of cutting-edge research and integrated industrial applications of photosynthetic microorganism based CO2 mitigation system, across a wide spectrum of energy and environment. The brief also presents sustainable perspectives of carbon concentrating mechanism in the context of current global energy and environmental challenges
    Note: Description based upon print version of record , IntroductionCarbon concentrating mechanism -- Carbon concentrating mechanism of cyanobacteria -- Carbon concentrating mechanism of microalgae -- Photosynthetic microorganisms based mitigation system: Integrated approaches for global sustainability.
    Additional Edition: ISBN 9783319091228
    Additional Edition: Erscheint auch als Druck-Ausgabe Singh, Shailendra Kumar Photosynthetic microorganisms Cham : Springer, 2014 ISBN 3319091220
    Additional Edition: ISBN 9783319091228
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Photosynthese ; Bakterien
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 17
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg
    UID:
    gbv_1653173181
    Format: Online-Ressource (VIII, 302 p. 15 illus., 2 illus. in color, online resource)
    ISBN: 9783642418372
    Series Statement: Soil Biology 39
    Content: Over the past 4 billion years, microorganisms have contributed to shaping the earth and making it more habitable for higher forms of life. They are remarkable in their metabolic diversity and their ability to harvest energy from oxidation and reduction reactions. Research on these microbiological processes has led to the newly evolving fields of geomicrobiology and biogeochemistry, linking the geosphere and the biosphere. This volume of the Soil Biology series provides an overview of the biogeochemical processes and the microorganisms involved, with an emphasis on the industrial applications. Topics treated include aspects such as bioremediation of contaminated environments, biomining, biotechnological applications of extremophiles, subsurface petroleum microbiology, enhanced oil recovery using microbes and their products, metal extraction from soil, soil elemental cycling and plant nutrition
    Note: Description based upon print version of record , Nagina Parmar and Ajay Singh: GeobiotechnologyNadine Loick and Christopher Weisener: Novel Molecular Tools to Assess Microbial Activity in Contaminated Environments -- Anu Kalia and Vir R. Parshad: Advanced Molecular and Microspectroscopy Toolbox for Deciphering Soil Diazotroph Diversity -- Megha K. Purohit, Vikram H. Raval, Satya P. Singh: Haloalkaliphilic bacteria - Molecular diversity and biotechnological applications -- Asha A. Juwarkar, Rashmi R. Misra and Jitendra K. Sharma: Recent Trends in Bioremediation -- Arvind Sinha, Rajeshwari Sinha and Sunil K. Khare: Heavy Metal Bioremediation and Nanoparticle Synthesis by Metallophiles -- Bernhard Dold: Mineralogical and Geochemical Controls in Biomining and Bioremediation -- Lala Behari Sukla, Sunil Kumar Behera and N. Pradhan: Microbial Recovery of Nickel from Lateritic (Oxidic) Nickel Ore -- Ajay Singh, Jonathan D. Van Hamme, Ramesh C. Kuhad, Nagina Parmar and Owen P. Ward: Subsurface Petroleum Microbiology -- Satyavir S. Sindhu, Priyanka Parmar and Manisha Phour: Nutrient Cycling: Potassium Solubilization by Microorganisms and Improvement of Crop Growth -- Satyavir S. Sindhu, Manisha Phour, Sita Ram Choudhary and Deepika Chaudhary: Phosphorus Cycling: Prospects of using Rhizosphere Microorganisms for Improving Phosphorus Nutrition of Plants -- Ajay Singh, Nagina Parmar and Owen Ward: Biotechnology in Enhanced Petroleum Oil Recovery -- Innocent O. Oboh: The Chemistry of Removal of Inorganic Compounds from the Soil -- Nagina Parmar, Ajay Singh and Hammad Khan: Bioremediation of Contaminated Sites and Aquifers.
    Additional Edition: ISBN 9783642418365
    Additional Edition: Erscheint auch als Druck-Ausgabe Geomicrobiology and biogeochemistry Berlin : Springer, 2014 ISBN 3642418368
    Additional Edition: ISBN 9783642418365
    Language: English
    Subjects: Biology
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    Keywords: Bioremediation ; Mikrobielle Laugung ; Biotechnologie ; Geomikrobiologie ; Biogeochemie ; Geomikrobiologie ; Biotechnologie ; Umwelttechnik ; Biogeochemie ; Geobiologie ; Biogeochemie ; Biomineralisation ; Nährstoffhaushalt ; Geomikrobiologie ; Bakterien ; Bioremediation ; Mikrobielle Laugung ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 18
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    gbv_1656185695
    Format: Online-Ressource (XIII, 407 p. 47 illus., 38 illus. in color, online resource)
    ISBN: 9781489980656
    Series Statement: SpringerLink
    Content: miRNAs are a class of endogenous, small non-protein coding RNA molecules (approx. 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-ß and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
    Note: Description based upon print version of record , Preface; Contents; Contributors; Part I; The Functions and Mechanisms of MicroRNAs; Chapter 1; miRNA Biogenesis and Function; 1 The Discovery of miRNAs; 2 Understanding miRNA Biogenesis; 2.1 Canonical miRNA Biogenesis: Dicer; 2.2 Canonical miRNA Biogenesis: Drosha; 2.3 Canonical miRNA Biogenesis: Nuclear Export; 2.4 Canonical miRNA Biogenesis: Transcription; 3 Noncanonical miRNA Biogenesis; 3.1 Microprocessor-Independent miRNA Biogenesis; 3.2 Dicer-Independent miRNA Biogenesis; 4 Regulation of miRNA Biogenesis; 5 Understanding miRNA Function; 5.1 Assembly of the RNA-Induced Silencing Complex , Selection of the Functional miRNA Strand Canonical miRNA Target Recognition; 6 Noncanonical miRNA Target Recognition; 7 Mechanisms of miRNA-Mediated Gene Silencing; 8 Regulation of miRNA Function; 9 Conclusions; References; Chapter 2; MicroRNAs in Cancer Progression; 1 Cancer Overview; 2 miRNAs; 3 miRNAs as Oncogenes; 4 miRNAs as Tumor Suppressors; 5 miRNA Function in Hallmarks of Cancer; 6 miRNAs and Chemoresistance; 7 Therapeutic and Clinical Implications of miRNAs; 8 Conclusions and Future Perspectives; References; Chapter 3; MicroRNA, DNA Repair, and Cancer ; 1 Introduction , 2 MicroRNA Biogenesis, Regulation, and Cancer2.1 MiRNA Biogenesis: Core Components; 2.2 RNA Modifications; 2.3 Protein Modifications; 2.4 Protein-RNA Interactions; 2.5 Protein-Protein Interactions; 3 MicroRNAs in DNA Repair; 3.1 DNA Repair Mechanisms; 3.2 Core MMR Proteins-miR-155, miR-422a, miR-21; 3.3 NER Proteins-miR-192; 3.4 H2AX-miR-24, miR-138; 3.5 BRCA1-miR182, miR-146a; 3.6 ATM-miRNA421, miR-18a, miR-100, miR-101, miR-181; 3.7 Rad51-miR-96; 3.8 RAD52-miR-210, 373, miR-302; 4 miRNAs in Other DNA Damage Response Events; 5 Conclusions and Future Prospective; References; Part II , MicroRNAs in Stem Cells and Progression of CancerChapter 4; Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila; 1 Introduction; 2 miRNAs in Stem Cell Regulation; 3 miRNAs in Drosophila GSCs: Self-Renewal and Differentiation; 3.1 miRNA and Female GSC ; 3.2 miRNAs and male GSC ; 4 miRNAs in Drosophila SSCs; 5 miRNAs in Tumorigenesis in Drosophila; 6 Conclusion; References; Chapter 5; MicroRNAs in Stem Cells and Cancer Stem Cells; 1 Introduction; 2 Stem Cells: Overview; 2.1 Discovery of Stem Cells; 2.2 Defining Stem Cells; 2.3 Sources of Stem Cells , 2.4 Niche in Stem Cell Regulation2.5 Self-Renewal and Differentiation of Stem Cells; 2.6 Stem Cell Quiescence; 3 Cancer Stem Cell; 3.1 The CSC hypothesis; 3.2 Emerging Evidence on the CSC Hypothesis; 3.3 Targeted Therapy for Stem-Like Cancer Cells; 4 MicroRNA; 5 Connexins; 6 Stromal Cell-Derived Factor 1/CXCL12; 6.1 Overview; 6.2 Emerging Role of CXCL12 in Cancer Biology; 6.3 CXCL12-CXCR4 Signaling Loops in Cancer; 6.4 CXCL12 in Tumor Dormancy: Pharmacological Targeting; 7 miRNA and CSC; 8 Conclusion; References; Chapter 6 , MicroRNAs in Epithelial Mesenchymal Transition and Breast Cancer Progression
    Additional Edition: ISBN 9781489980649
    Additional Edition: Erscheint auch als Druck-Ausgabe MicroRNA in development and in the progression of cancer New York : Springer, 2014 ISBN 9781489980649
    Language: English
    Subjects: Biology
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    Keywords: miRNS ; Carcinogenese ; miRNS ; Krebs ; Wachstum ; miRNS ; Carcinogenese ; miRNS ; Krebs ; Wachstum
    URL: Cover
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  • 19
    Online Resource
    Online Resource
    Singapore : Springer Singapore | Singapore : Imprint: Springer
    UID:
    gbv_1737524945
    Format: 1 Online-Ressource(XIII, 306 p. 80 illus., 54 illus. in color.)
    Edition: 1st ed. 2020.
    ISBN: 9789811568152
    Series Statement: Springer eBook Collection
    Content: 1 Computational Approaches in Drug Discovery and Design -- 2 Molecular Modeling of Proteins: Methods, Recent Advances and Future Prospects -- 3 Cavity/Binding Site Prediction Approaches, and their Applications -- 4 Role of ADMET Tools in Current Scenario; Application and Limitations -- 5 Database Resources for Drug Discovery -- 6 Molecular Docking and Structure-Based Drug Design -- 7 Molecular Dynamics Simulation of Protein and Protein-Ligand Complexes -- 8 Computational Approaches for Drug Target Identification -- 9 Computational Screening Techniques for Lead Design and Development -- 10 Advances in Pharmacophore Modeling and its Role in Drug Designing -- 11 In Silico Designing of Vaccines: Methods, Tools and Their Limitations -- 12 Machine learning Approaches to Rational Drug Design. .
    Content: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
    Additional Edition: ISBN 9789811568145
    Additional Edition: ISBN 9789811568169
    Additional Edition: ISBN 9789811568176
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9789811568145
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9789811568169
    Additional Edition: Erscheint auch als Druck-Ausgabe Computer-aided drug design Singapore : Springer, 2020 ISBN 9789811568176
    Language: English
    Subjects: Chemistry/Pharmacy , Biology
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  • 20
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    gbv_1654458422
    Format: Online-Ressource (XIX, 410 p. 69 illus., 53 illus. in color, online resource)
    ISBN: 9781493904648
    Series Statement: Advances in Biochemistry in Health and Disease 10
    Content: Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development
    Note: Description based upon print version of record , Phospholipases in Health and DiseaseRole of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development  and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLCζ): Male Infertility and  Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease.
    Additional Edition: ISBN 9781493904631
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-149-390-463-1
    Language: English
    Subjects: Biology , Medicine
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    Keywords: Phospholipasen
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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