In:
Journal of Applied Physiology, American Physiological Society, Vol. 19, No. 3 ( 1964-05-01), p. 403-407
Abstract:
We examined pulmonary gas exchange in 19 anesthetized dogs during the induction of acute pulmonary edema by intravenous infusion of dextran in saline. We monitored pulmonary capillary pressure by a left atrial catheter, and arterial blood Po 2 by an indwelling electrode. Pa O O2 remained near normal until just before pulmonary edema was grossly apparent, when it fell precipitously; left atrial pressure mounted to a peak and then declined. The apparent “steady-state” Dl CO was reduced as much as 61%, but the dominant cause of hypoxemia was an increased venous admixture (shunt flow) on O 2 breathing. Since the shunt was reversible by forcible inflation of the lungs, induced pulmonary edema was probably associated with closure of alveolar units. pulmonary venous admixture (shunt flow) and diffusing capacity; alveolar closure; arterial blood oxygen; tension in vivo; hypoxemia Submitted on August 14, 1963
Type of Medium:
Online Resource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/jappl.1964.19.3.403
Language:
English
Publisher:
American Physiological Society
Publication Date:
1964
detail.hit.zdb_id:
1404365-8
SSG:
12
SSG:
31
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