In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 54, No. 4 ( 1967-04), p. 681-695
Abstract:
In 50 patients determinations of blood sugar and corticosteroids in plasma (11-OHCS) were carried out during insulin-induced hypoglycaemia. In 9 out of 11 patients with Cushing's syndrome (bilateral adrenal hyperplasia) the characteristic finding was a missing increase of 11-OHCS concentrations during hypoglycaemia. On the contrary, 5 patients with alimentary obesity and clinical signs of hypercorticism showed a normal or even increased adrenocortical response. The results obtained in 7 patients with uncomplicated central diabetes insipidus did not differ from those in normal subjects, while 2 further patients with diabetes insipidus, complicated with secondary adrenocortical insufficiency, failed to respond. Findings in 12 patients with anorexia nervosa are consistent with a normal function of the hypothalamo-pituitary-adrenal axis. According to plasma corticosteroid response during hypoglycaemia results obtained in 15 patients with disorders of hypothalamus and/or hypophysis may be divided into three groups. The significance of this classification with regard to replacement therapy is discussed. Observations show that plasma corticosteroid estimations during insulin-induced hypoglycaemia provide a simple and reliable method to ascertain the function of the hypothalamo-pituitary-adrenal axis (insulinhypoglycaemiatest).
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0540681
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1967
detail.hit.zdb_id:
1485160-X
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