Umfang:
Online-Ressource (digital)
ISBN:
9780387746722
Serie:
Advances in Experimental Medicine and Biology 612
Inhalt:
This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.
Inhalt:
Relaxin and Related Peptides discusses the established paradigms, the contradictions, and the most recent findings and future directions in the field of relaxin research. The array of diverse topics are highlighted, ranging from evolution of relaxin family peptides and receptors to their cell signaling, from the role of relaxin in reproduction to the newly discovered functions in cancer progression and in the nervous system. This book includes chapters written by well-known experts in the relaxin field who are actively involved in shaping this rapidly evolving science. The four major ongoing areas of research described in this book will likely attract investigators for years to come, since many basic scientific questions remain unanswered at this time. The availability of structural databases, new experimental techniques, and high quality hormone preparations, antibodies and other reagents enable rigorous investigation. Relaxin and Related Peptides offers a fresh perspective along with different points of view, opinions and disagreements.
Anmerkung:
Includes bibliographical references and index
,
CONTENTS; PREFACE; FOREWORD; 1. THE EVOLUTION OF THE RELAXIN PEPTIDE FAMILY AND THEIR RECEPTORS; Abstract; Introduction; The Relaxin Peptides; Relaxin; Relaxin-3; Insulin-Like Peptide 3 (INSL3); Insulin-Like Peptide 4 (INSL4); Insulin-Like Peptide 5 (INSL5); Insulin-Like Peptide 6 (INSL6); The Evolution of the Relaxin Peptide Family; The Relaxin Peptide Family Receptors; Leucine Rich Repeat Containing G Protein-Coupled Receptors 7 and (LGR7 and LGR8); GPCR135 and GPCR142; Receptor Nomenclature; The Evolution of the Relaxin Peptide Family Receptors
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Co-Evolution of the Relaxin Peptide Family and Their Receptors2. RELAXIN, THE RELAXIN-LIKE FACTOR AND THEIR RECEPTORS; Abstract; Relaxin; RLF; 3. DIVERSE SIGNALLING MECHANISMS USED BY RELAXIN IN NATURAL CELLS AND TISSUES: THE EVOLUTION OF A ""NEOHORMONE''; Abstract; Introduction; Evolution of Signalling Systems; Relaxin as a Model Neohormone System; Stimulation of cAMP Accumulation; Relaxin Stimulation of PI3-Kinase and Protein Kinase C5 (PKC5); Is Relaxin Action Connected to Ca++ Flux in Stimulated Cells?; Relaxin Can Act Through the Glucocorticoid Receptor (GR)
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Downstream Effects of Relaxin-Dependent Cell SignallingLocal Relaxin Systems; Concluding Remarks; 4. RELAXIN PHYSIOLOGY IN THE FEMALE REPRODUCTIVE TRACT DURING PREGNANCY; Abstract; Introduction; Relaxin Receptors; Effects of Relaxin on the Cervix; Effects of Relaxin on the Vagina; Effects of Relaxin on the Uterus; Summary; 5. RELAXIN AND RELATED PEPTIDES IN MALE REPRODUCTION; Abstract; Relaxin in Male Reproduction; Other Relaxin Peptides in Male Reproduction; Insulin-Like Peptide 3 (INSL3); Summary and Future Directions; 6. THE VASCULAR ACTIONS OF RELAXIN; Abstract; Introduction
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Part 1. Contribution of Relaxin to Normal Vascular FunctionPart 2. Relaxin and Vascular Dysfunction: Implications for Relaxin as a Therapeutic Agent; Part 3. Controversies, Unresolved Issues and Future Directions; 7. THE EFFECTS OF RELAXIN ON EXTRACELLULAR MATRIX REMODELING IN HEALTH AND FIBROTIC DISEASE; Abstract; Introduction; The Extracellular Matrix (ECM); Fibroblasts; Fibrosis; The Matrix Remodeling Effects of Exogenous Relaxin; The Protective Effects of Endogenous Relaxin; Mechanism of Relaxin's Antifibrotic Properties; Conclusions
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8. RELAXIN-LIKE LIGAND-RECEPTOR SYSTEMS ARE AUTOCRINE/PARACRINE EFFECTORS IN TUMOR CELLS AND MODULATE CANCER PROGRESSION AND TISSUE INVASIVENESSAbstract; Introduction; Prostate Cancer; Thyroid Cancer; Cancer of Female Organs with Reproductive Functions; Future Directions; 9. RELAXIN-FAMILY PEPTIDE AND RECEPTOR SYSTEMS IN BRAIN; Abstract; Discovery of Relaxin Family Genes and Peptides; Human and Rodent Relaxin Family Peptides - Gene Characteristics and Biosynthesis; Relaxin Family Peptide Receptors: Discovery, Distribution and Structure-Activity
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Relaxin and Related Peptides: Peripheral and Central Distribution
Weitere Ausg.:
ISBN 9780387746708
Weitere Ausg.:
Buchausg. u.d.T. Relaxin and related peptides New York, NY : Springer Science+Business Media LLC, 2007 ISBN 9780387746708
Weitere Ausg.:
ISBN 0387746706
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Relaxin
;
Physiologische Chemie
;
Relaxin
;
Konferenzschrift
;
Aufsatzsammlung
DOI:
10.1007/978-0-387-74672-2
URL:
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