Format:
Online-Ressource (digital)
ISBN:
9780387782676
Series Statement:
Subcellular Biochemistry 47
Content:
In biological terms, a parasite can be defined as an organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host. 1 This relationship is particularly intimate for parasitic protozoa (and single-celled fungi such as the Microsporidia), many of which not only penetrate tissue barriers, but gain entry into host cells. The entry mechanisms are as diverse as the organisms employing them and are often critical components of their pathogenic profile. All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here (Plasmodium falciparum, Toxoplasma gondii, Cryptosporidium parvum, Trypanosoma cruzi and Leishmania spp.) the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, such as Entamoeba, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Note:
Includes bibliographical references and index
,
CONTENTS; 1. Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites; 2. Microneme Proteins in Apicomplexans; 3. Erythrocyte Invasion by Plasmodium falciparum: Multiple Ligand-Receptor Interactions and Phenotypic Switching; 4. Role of the gp85/Trans-Sialidase Superfamily of Glycoproteins in the Interaction of Trypanosoma cruzi with Host Structures; 5. Calcium Regulation and Signaling in Apicomplexan Parasites; 6. Trypanosoma cruzi: Parasite and Host Cell during the Invasion Process; 7. Host Cell Actin Remodeling in Response to Cryptosporidium
,
8. Host Cell Actin Remodeling in Response to Trypanosoma cruzi: Trypomastigote Versus Amastigote Entry9. Actin/Myosin-Based Gliding Motility in Apicomplexan Parasites; 10. Roles of Proteases during Invasion and Egress by Plasmodium and Toxoplasma; 11. Roles of Naturally Occuring Protease Inhibitors in the Modulation of Host Cell Signaling and Cellular Invasion by Trypanosoma cruzi; 12. Biogenesis of and Activities at the Toxoplasma gondii Parasitophorous Vacuole Membrane; 13. The Role of Host Cell Lysosomes in Trypanosoma cruzi Invasion; 14. Leishmania Invasion and Phagosome Biogenesis
,
15. Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer16. Transepithelial Migration by Toxoplasma; 17. The Microsporidian Polar Tube and Its Role in Invasion; 18. Intestinal Invasion by Entamoeba histolytica; Index
Additional Edition:
ISBN 9780387782669
Additional Edition:
Buchausg. u.d.T. Molecular mechanisms of parasite invasion New York, NY [u.a.] : Springer [u.a.], 2008 ISBN 0387782664
Additional Edition:
ISBN 9780387782669
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Pathogener Mikroorganismus
DOI:
10.1007/978-0-387-78267-6
Bookmarklink
