Format:
Online-Ressource (XVI, 310 p)
,
online resource
Edition:
Springer eBook Collection. Biomedical and Life Sciences
ISBN:
9781461506195
Content:
This book has a strong focus on the role APN and DPIV play in the hematopoietic system, where again signal peptides and small proteins (cytokines) are among the most interesting substrates. Additionally, both the membrane bound peptidases play roles as partners in signal transduction of lymphocytes and monocytes, and inhibition of their enzymatic activity results in cell cycle arrest, inhibition of DNA synthesis and characteristic changes of cytokine secretion pattern of T cells. This knowledge more and more is used as the base of therapeutic strategies in the treatment of a variety of inflammatory and autoimmune diseases as well as of tumors of different origin. The editors themselves with their colleagues have contributed important results about APN and DPIV that are reviewed here, and additionally, most of the leading groups in this field from Europe, U.S., Australia and Japan have contributed reviews and latest, partially unpublished results of their work
Note:
1 Detection of the Activity of the Ectopeptidases DPIV and APN Using Sensitive Fluorogenic Substrates2 CD13/APN in Hematopoetic Cells - Expression, Function, Regulation, and Clinical Aspects -- 3 New Selective Aminopeptidase N Inhibitors as Potential Therapeutics -- 4 Physiological Roles of Ectoenzymes Indicated by the Use of Aminopeptidase Inhibitors -- 5 CD13/APN as a Target for Inhibiting Tumor Angiogenesis: A Molecular Basis for the Differential Expression of CD13/APN in Vascular Endothelium -- 6 Signal Transduction via Membrane Peptidases -- 7 The Family of CD26/DPIV and Related Ectopeptidases - The DPIV Family. -- 8 CD26/DPIV in Hematopoietic Cells - Expression, Function, Regulation, Clinical Aspects -- 9 DPIV - Natural Substrates of Medical Importance -- 10 Therapeutic Strategies Exploiting DP IV inhibition - Target Disease: Type 2 Diabetes -- 11 CD26/DPIV in Diseases of the Central Nervous System -- 12 CD26/DPIV in Stress-induced, Cytokine-mediated Abortions.
Additional Edition:
ISBN 9781461351610
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9781461351610
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9780306467882
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9781461506201
Language:
English
DOI:
10.1007/978-1-4615-0619-5
URL:
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