Kooperativer Bibliotheksverbund

UID:

Format: Online-Ressource (digital)

ISBN: 9780387746722

Series Statement: Advances in Experimental Medicine and Biology 612

Content: This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Content: Relaxin and Related Peptides discusses the established paradigms, the contradictions, and the most recent findings and future directions in the field of relaxin research. The array of diverse topics are highlighted, ranging from evolution of relaxin family peptides and receptors to their cell signaling, from the role of relaxin in reproduction to the newly discovered functions in cancer progression and in the nervous system. This book includes chapters written by well-known experts in the relaxin field who are actively involved in shaping this rapidly evolving science. The four major ongoing areas of research described in this book will likely attract investigators for years to come, since many basic scientific questions remain unanswered at this time. The availability of structural databases, new experimental techniques, and high quality hormone preparations, antibodies and other reagents enable rigorous investigation. Relaxin and Related Peptides offers a fresh perspective along with different points of view, opinions and disagreements.

Note: Includes bibliographical references and index , CONTENTS; PREFACE; FOREWORD; 1. THE EVOLUTION OF THE RELAXIN PEPTIDE FAMILY AND THEIR RECEPTORS; Abstract; Introduction; The Relaxin Peptides; Relaxin; Relaxin-3; Insulin-Like Peptide 3 (INSL3); Insulin-Like Peptide 4 (INSL4); Insulin-Like Peptide 5 (INSL5); Insulin-Like Peptide 6 (INSL6); The Evolution of the Relaxin Peptide Family; The Relaxin Peptide Family Receptors; Leucine Rich Repeat Containing G Protein-Coupled Receptors 7 and (LGR7 and LGR8); GPCR135 and GPCR142; Receptor Nomenclature; The Evolution of the Relaxin Peptide Family Receptors , Co-Evolution of the Relaxin Peptide Family and Their Receptors2. RELAXIN, THE RELAXIN-LIKE FACTOR AND THEIR RECEPTORS; Abstract; Relaxin; RLF; 3. DIVERSE SIGNALLING MECHANISMS USED BY RELAXIN IN NATURAL CELLS AND TISSUES: THE EVOLUTION OF A ""NEOHORMONE''; Abstract; Introduction; Evolution of Signalling Systems; Relaxin as a Model Neohormone System; Stimulation of cAMP Accumulation; Relaxin Stimulation of PI3-Kinase and Protein Kinase C5 (PKC5); Is Relaxin Action Connected to Ca++ Flux in Stimulated Cells?; Relaxin Can Act Through the Glucocorticoid Receptor (GR) , Downstream Effects of Relaxin-Dependent Cell SignallingLocal Relaxin Systems; Concluding Remarks; 4. RELAXIN PHYSIOLOGY IN THE FEMALE REPRODUCTIVE TRACT DURING PREGNANCY; Abstract; Introduction; Relaxin Receptors; Effects of Relaxin on the Cervix; Effects of Relaxin on the Vagina; Effects of Relaxin on the Uterus; Summary; 5. RELAXIN AND RELATED PEPTIDES IN MALE REPRODUCTION; Abstract; Relaxin in Male Reproduction; Other Relaxin Peptides in Male Reproduction; Insulin-Like Peptide 3 (INSL3); Summary and Future Directions; 6. THE VASCULAR ACTIONS OF RELAXIN; Abstract; Introduction , Part 1. Contribution of Relaxin to Normal Vascular FunctionPart 2. Relaxin and Vascular Dysfunction: Implications for Relaxin as a Therapeutic Agent; Part 3. Controversies, Unresolved Issues and Future Directions; 7. THE EFFECTS OF RELAXIN ON EXTRACELLULAR MATRIX REMODELING IN HEALTH AND FIBROTIC DISEASE; Abstract; Introduction; The Extracellular Matrix (ECM); Fibroblasts; Fibrosis; The Matrix Remodeling Effects of Exogenous Relaxin; The Protective Effects of Endogenous Relaxin; Mechanism of Relaxin's Antifibrotic Properties; Conclusions , 8. RELAXIN-LIKE LIGAND-RECEPTOR SYSTEMS ARE AUTOCRINE/PARACRINE EFFECTORS IN TUMOR CELLS AND MODULATE CANCER PROGRESSION AND TISSUE INVASIVENESSAbstract; Introduction; Prostate Cancer; Thyroid Cancer; Cancer of Female Organs with Reproductive Functions; Future Directions; 9. RELAXIN-FAMILY PEPTIDE AND RECEPTOR SYSTEMS IN BRAIN; Abstract; Discovery of Relaxin Family Genes and Peptides; Human and Rodent Relaxin Family Peptides - Gene Characteristics and Biosynthesis; Relaxin Family Peptide Receptors: Discovery, Distribution and Structure-Activity , Relaxin and Related Peptides: Peripheral and Central Distribution

Additional Edition: ISBN 9780387746708

Additional Edition: Buchausg. u.d.T. Relaxin and related peptides New York, NY : Springer Science+Business Media LLC, 2007 ISBN 9780387746708

Additional Edition: ISBN 0387746706

Language: English

Subjects: Biology

Keywords: Relaxin ; Physiologische Chemie ; Relaxin ; Konferenzschrift ; Aufsatzsammlung

DOI: 10.1007/978-0-387-74672-2

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource , v.: digital

Edition: Online-Ausg. Springer-11642

Edition: Springer eBook Collection. Biomedical and Life Sciences

ISBN: 9780306479205

Series Statement: Advances in Experimental Medicine and Biology 524

Content: Structure and Function of Dipeptidyl Aminopeptidases -- Dipeptidyl Peptidase IV Substrates -- Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity -- Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis -- Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV — a Side Effect in the Use of Inhibitors? -- Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family -- The Specificity of DP IV for Natural Substrates is Peptide Structure Determined -- New Results on the Conformations of Potent DP IV (CD26) Inhibitors bearing the N-terminal MWP Structural Motif -- Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides -- Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System -- DPP IV-Like Enzymes -- Dipeptidyl Peptidase IV Gene Family -- Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex -- Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells -- Characterisation of Human DP IV Produced by a Pichia pastoris Expression System -- Isolation and Characterization of Attractin-2 -- Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance -- Immune Mechanisms and Immune Disorders -- Synergistic Action of DPIV and APN in the Regulation of T Cell Function -- CD26/DPP IV in Experimental and Clinical Organ Transplantation -- CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation -- Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions -- Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production -- Dipeptidyl Peptidase IV Inhibitors with the N-terminal MXP Sequence: Structure-Activity-Relationships -- On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease -- The Properties of Human and Bovine CD8+CD26+ T Cells Induced by a Microbial Superantigen -- Angiogenesis and Cancer -- DPPIV and Seprase in Cancer Invasion and Angiogenesis -- Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target -- Dual Role of Dipeptidyl Peptidase IV (DPP IV) in Angiogenesis and Vascular Remodeling -- CD26 Expression on Cutaneous Infiltrates from Patients with Cutaneous T-Cell Lymphoma (CTCL) -- Intrahepatic Expression of Collagen and Fibroblast Activation Protein (FAP) in Hepatitis C Virus Infection -- Expression of CD26/Dipeptidyl Peptidase IV in Endometrial Adenocarcinoma and its Negative Correlation with Tumor Grade -- Adhesion Potency to Mesothelial Cells by Overexpression of Dipeptidyl Peptidase IV -- Survival Time and Invasive Activity due to Dipeptidyl Peptidase IV Overexpression in Ovarian Carcinoma -- Dipeptidylpeptidase IV Activities in Prostatic Secretions -- Diabetes and Metabolism -- Implementation of GLP-1 Based Therapy of Type 2 Diabetes Mellitus Using DPP-IV Inhibitors -- Dipeptidyl Peptidase IV Inhibition in Animal Models of Diabetes -- Glucose-dependent Insulinotropic Polypeptide (GIP): Development of DP IV-Resistant Analogues with Therapeutic Potential -- Neutral Endopeptidase 24.11 and Dipeptidyl Peptidase IV are Both Involved in Regulating the Metabolic Stability of Glucagon-like Peptide-1 in vivo -- DPP IV, Immune Parameters, and Psychometrical Variables in Patients with Eating Disorders -- DPP IV and Mental Depression in Crohn’s Disease -- Microscopic Acid-Base Equilibra of Alanyl-boroAlanine -- Acylated Hydroxamates as Selective and Highly Potent Inhibitors of Dipeptidyl Peptidase I -- CD26-/DPP IV-Positive Lymphocytes in Murine Acute Experimental Colitis -- Neuroprotective Effects of Inhibitors of Dipeptidyl Peptidase-IV In Vitro and In Vivo.

Content: Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

Additional Edition: ISBN 9780306477171

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781475787306

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9781475787290

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780306477171

Language: English

Keywords: Kongress ; Dipeptidylpeptidase IV

DOI: 10.1007/b105297

URL: Volltext

URL: lizenzpflichtig

UID:

Format: Online-Ressource , v.: digital

ISBN: 9780387095509

Series Statement: Advances in Experimental Medicine and Biology 635

Note: In: Springer-Online

Language: English

Subjects: Biology

Keywords: Electronic books

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9789048122592

Series Statement: Advances in Experimental Medicine and Biology 648

Additional Edition: ISBN 9789048122585

Additional Edition: Buchausg. u.d.T. ISBN 978-90-481-2258-5

Language: English

Subjects: Biology

Keywords: Glomus caroticum ; Chemorezeptor

DOI: 10.1007/978-90-481-2259-2

URL: Volltext  (lizenzpflichtig)

URL: Volltext  (lizenzpflichtig)

URL: Volltext  (lizenzpflichtig)

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387767154

Series Statement: Advances in Experimental Medicine and Biology 621

Content: This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.

Content: This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring. The journey starts with a description of the classical guidance signals such as the netrins, the semaphorins, the ephrins or the Slit family. The question of the exact definition of a guidance signal is addressed in a chapter which discusses whether neurotrophic factors can be considered as guidance cues. This complex question is also considered in a chapter presenting the role of adhesion molecules during axon guidance and the report of compelling evidence for a guidance effect of neurotransmitters. The diversity of the molecular cues used by growth cones to reach their targets is finally illustrated in a chapter describing the unexpected role of morphogenes as direct guidance signals.

Note: Includes bibliographical references and index , CONTENTS; PREFACE; 1. MOLECULAR MECHANISMS OF AXONAL GROWTH; Introduction; The Neuronal Growth Cone and its Cytoskeletal Organization; Mechanisms of Axonal Elongation; Regulation of the Cytoskeleton by Extracellular Cues, Role of Rho-GTPases; Growth Cone of Regenerating Axons; 2. NETRINS AND THEIR RECEPTORS; Introduction; Netrin Structure; Functional Roles for Netrins during Nervous System Development; Netrin Signal Transduction; Netrin in the Adult Nervous System; Conclusion and Perspectives; 3.Eph RECEPTORS AND EPHRIN LIGANDS IN AXON GUIDANCE; Introduction; Molecular Structure , Mechanisms of Signal TransductionFunctional Implications during Nervous System Development; Conclusion and Perspectives; 4. ROLE OF SEMAPHORINS DURING AXON GROWTH AND GUIDANCE; Introduction; Functional Roles of Semaphorins during Axon Guidance; Receptors of Secreted-Semaphorins: The Neuropilins; Receptors of Transmembrane-Semaphorins: The Plexin Family; Other Receptors Associated with Semaphorin Signaling; Intracellular Signal Transduction; Conclusion; 5. SLITS AND THEIR RECEPTORS; Introduction; Robo Partners; Molecular Control of Slit and Robo Expression , Multiple Functions for Slit/Robo in the Nervous SystemA Role for Slit and Robo in Neurological Disorders?; Perspectives; 6. NEUROTROPHIC FACTORS: ARE THEY AXON GUIDANCE MOLECULES?; Introduction; Evaluation of Neurotrophic Factors as Axon Guidance Molecules; The Discovery of the Neurotrophins; The Extended Family of Neurotrophic Factors; Neurotrophic Factors Can Promote Axon Growth and Orient Axons in Vitro; Neurotrophic Factors and Axon Guidance Molecules Use Common Signalling Pathways; The Role of Signalling Pathways in Axonal Chemoattraction by Neurotrophins and Netrin-l , Role of cAMP and Calcium Concentrations in ChemoattractionIn Vivo Tests of Neurotrophic Factors in Axon Guidance; Role of Neurotrophic Factors in Branching; Conclusions; 7. THE ROLE OF CELL ADHESION MOLECULES IN AXON GROWTH AND GUIDANCE; Introduction; Molecular Structure; Biophysical and Signaling Mechanisms; Functional Implication; Conclusion; 8. NEUROTRANSMITTERS AND THE DEVELOPMENT OF NEURONAL CIRCUITS; Introduction; Effects of Neurotransmitters on Growth Cone Steering; Glutamate: An Excitatory Transmitter and a Versatile Developmental Signal , Acetylcholine Acts as a Neuronal Guidance Signal during Brain DevelopmentThere Is More to GABA Than Synaptic Inhibition; Conclusions; 9. THE HEDGEHOG, TGF-ß/BMP AND Wnt FAMILIES OF MORPHOGENS IN AXON GUIDANCE; Introduction; Morphogens, Cell Fate Specification and Tissue Patterning; Morphogens in Axon Guidance; Interpreting Positional Information: Signaling Components in Axon Guidance and Cell Fate Specification; Conclusions and Perspectives; 10. THE ROLE OF CYCLIC NUCLEOTIDES IN AXON GUIDANCE; Introduction; Molecular Structure of Cyclic Nucleotides; Mechanisms of Signal Transduction , Functional Implications during Nervous System Development

Additional Edition: ISBN 9780387767147

Additional Edition: Buchausg. u.d.T. Axon growth and guidance New York, NY : Springer [u.a.], 2007 ISBN 9780387767147

Additional Edition: ISBN 0387767142

Language: English

Subjects: Biology

Keywords: Axon ; Physiologie ; Nervensystem ; Wachstum ; Axon ; Wachstum ; Genregulation ; Aufsatzsammlung

DOI: 10.1007/978-0-387-76715-4

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387788852

Series Statement: Advances in Experimental Medicine and Biology 631

Content: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.

Content: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.

Note: Includes bibliographical references and index , CONTENTS; 1. INTRODUCTION TO BACTERIAL SIGNAL TRANSDUCTION NETWORKS; 2. THE PHOQ/PHOP REGULATORY NETWORK OF SALMONELLA ENTERICA; 3. STRUCTURAL BASIS OF THE SIGNAL TRANSDUCTION IN THE TWO-COMPONENT SYSTEM; 4. THE TWO-COMPONENT NETWORK AND THE GENERAL STRESS SIGMA FACTOR RPOS (OS) IN ESCHERICHIA COLI; 5. SMALL RNAS CONTROLLED BY TWO-COMPONENT SYSTEMS; 6. TWO-COMPONENT SIGNALING AND GRAIN NEGATIVE ENVELOPE STRESS RESPONSE SYSTEMS; 7. DUAL REGULATION WITH SER/THR KINASE CASCADE AND A HIS/ASP TCS IN MYXOCOCCUS XANTHUS , 8. TWO-COMPONENT SIGNALING SYSTEMS AND CELL CYCLE CONTROL IN CAULOBACTER CRESCENTUS9. REGB/REGA, A GLOBAL REDOX-RESPONDING TWO-COMPONENT SYSTEM; 10. THE BVGS/BVGA PHOSPHORELAY SYSTEM OF PATHOGENIC BORDETELLAE: STRUCTURE, FUNCTION AND EVOLUTION; 11. CAPTURING THE VIRA/VIRG TCS OF AGRPBACTERIUM TUMEFACIENS; 12. QUORUM SENSING AND BIOFILM FORMATION BY STREPTOCOCCUS MUTANS; 13 THE ROLES OF TWO-COMPONENT SYSTEMS IN VIRULENCE OF PATHOGENIC ESCHERICHIA COLI AND SHIGELLA SPP; 14. VANCOMYCIN RESISTANCE VANS/VANR TWO-COMPONENT SYSTEMS , 15 TEARING DOWN THE WALL: PEPTIDOGLYCAN METABOLISM AND THE WALK/WALKR (YYCG/YYCF) ESSENTIAL TWO-COMPONENT SYSTEM16. INHIBITORS TARGETING TWO-COMPONENT SIGNAL TRANSDUCTION; INDEX

Additional Edition: ISBN 9780387788845

Additional Edition: Buchausg. u.d.T. Bacterial signal transduction: networks and drug targets New York [u.a.] : Springer Science+Business Media, LLC [u.a.], 2008 ISBN 9780387788845

Additional Edition: ISBN 0387788840

Language: English

Subjects: Biology

Keywords: Bakterien ; Signaltransduktion ; Genregulation ; Pharmakologie ; Aufsatzsammlung

DOI: 10.1007/978-0-387-78885-2

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387859989

Series Statement: Advances in Experimental Medicine and Biology 645

Content: This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

Content: Covers various aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. This book pays attention to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation

Note: Includes bibliographical references and index , Selected conference papers , CONTENTS; AIR AND FIRE - Carl Wilhelm Scheele, Torbern Bergman, The Royal Society of Sciences and the discovery of oxygen in Uppsala in 1772; MATHEMATICAL MODELING OF THE INTERACTION BETWEEN OXYGEN, NITRIC OXIDE AND SUPEROXIDE; HAEMOGLOBIN SATURATION CONTROLS THE RED BLOOD CELL MEDIATED HYPOXIC VASORELAXATION; BLOOD VESSEL SPECIFIC VASO-ACTIVITY TO NITRITE UNDER NORMOXIC AND HYPOXIC CONDITIONS; NITRITE-INDUCED IMPROVED BLOOD CIRCULATION ASSOCIATED WITH AN INCREASE IN A POOL OF RBC-NO WITH NO BIOACTIVITY; THE CONTROL OF OXIDATIVE PHOSPHORYLATION IN THE ADRENAL GLAND (Y1) CELL LINE , REPLICATION OF MURINE MITOCHONDRIAL DNA FOLLOWING IRRADIATIONEFFECTS OF ANESTHESIA ON BRAIN MITOCHONDRIAL FUNCTION, BLOOD FLOW, IONIC AND ELECTRICAL ACTIVITY MONITORED IN VIVO; THE INFLUENCE OF FLOW REDISTRIBUTION ON WORKING RAT MUSCLE OXYGENATION; HETEROGENEITY OF CAPILLARY SPACING IN THE HYPERTROPHIED PLANTARIS MUSCLE FROM YOUNG-ADULT AND OLD RATS; MICROVASCULARITY OF THE LUMBAR ERECTOR SPINAE MUSCLE DURING SUSTAINED PRONE TRUNK EXTENSION TEST; FIBER CAPILLARY SUPPLY RELATED TO FIBER SIZE ANDOXIDATIVE CAPACITY IN HUMAN AND RAT SKELETAL MUSCLE , NOVEL THERAPEUTIC APPROACH TARGETING THE HIF-HRE SYSTEM IN THE KIDNEYCAROTID BODY SENSORY DISCHARGE AND GLOMUS CELL HIF-1a ARE REGULATED BY A COMMON OXYGEN SENSOR; IMPACT OF REACTIVE OXYGEN SPECIES ON THE EXPRESSION OF ADHESION MOLECULES IN VIVO; MINI SENSING CHIP FOR POINT-OF-CARE ACUTE MYOCARDIAL INFARCTION DIAGNOSIS UTILIZING MICRO-ELECTRO-MECHANICAL SYSTEM AND NANO-TECHNOLOGY; A CHEMICAL BIOSYNTHESIS DESIGN FOR AN ANTIATHEROSCLEROSIS DRUG BY ACYCLIC TOCOPHEROL INTERMEDIATE ANALOGUE BASED ON "ISOPRENOMICS"; ZYMOGEN PROTEIN C CONCENTRATE FOR SAFER HETEROZYGOTE SURGERY, "I AM A GUINEA PIG!" , STEADY STATE REDOX LEVELS IN CYTOCHROME OXIDASE: RELEVANCE FOR IN VIVO NEAR INFRARED SPECTROSCOPY (NIRS)BICUCULLINE-INDUCED SEIZURES: A CHALLENGE FOR OPTICAL AND BIOCHEMICAL MODELING OF THE CYTOCHROME OXIDASE CU A NIRS SIGNAL; A METHOD TO CALCULATE ARTERIAL AND VENOUS SATURATION FROM NEAR INFRARED SPECTROSCOPY (NIRS); DEVELOPMENT OF A DYNAMIC TEST PHANTOM FOR OPTICAL TOPOGRAPHY; NUMERICAL SIMULATION OF OXYGEN TRANSPORT IN CEREBRAL TISSUE; NON-INVASIVE ESTIMATION OF METABOLIC FLUX AND BLOOD FLOW IN WORKING MUSCLE: EFFECT OF BLOOD-TISSUE DISTRIBUTION , OXYGEN EXTRACTION INDEX MEASURED BY NEAR INFRAREDSPECTROSCOPY - A PARAMETER FOR MONITORING TISSUEOXYGENATION?NON-INVASIVE MEASUREMENT OF THE SUPERFICIAL CORTICAL OXYGEN PARTIAL PRESSURE; ONE SENSOR FITS ALL - A NEW APPROACH IN MONITORING BRAIN PHYSIOLOGY; EVALUATION OF NIRS DATA BASED ON THEORETICAL ANALYSIS OF OXYGEN TRANSPORT TO CEREBRAL TISSUE; MYOCARDIAL CAPILLARY NET AND BLOOD CONSTITUENTS IN STREPTOZOTOCIN (STZ)- INDUCED DIABETIC RATS; EFFECTS OF PROINSULIN C-PEPTIDE ON OXYGEN TRANSPORT, UPTAKE AND UTILIZATION IN INSULINOPENIC DIABETIC SUBJECTS - A REVIEW , REDUCED OXYGENATION IN DIABETIC RAT KIDNEYS MEASURED BY T2* WEIGHTED MAGNETIC RESONANCE MICRO-IMAGING , Air and fire : Carl Wilhelm Scheele, Torbern Bergman, the Royal Society of Sciences and the discovery of oxygen in Uppsala in 1772 , Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation , Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions , Nitrite-induced improved blood circulation associated with an increase in a pool of RBN-NO with NO bioactivity , The control of oxidative phosphorylation in the adrenal gland (Y1) cell line , Replication of murine mitochondrial DNA following irradiation , Effects of anesthesia on brain mitochondrial function, blood flow, ionic and electrical activity monitored in vivo , The influence of flow redistribution on working rat muscle oxygenation , Heterogeneity of capillary spacing in the hypertrophied plantaris muscle from young-adult and old rats , Microvascularity of the lumbar erector spinae muscle during sustained prone trunk extension test , Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle , Novel therapeutic approach targeting the HIF-HRE system in the kidney , Carotid body sensory discharge and glomus cell HIF-1[alpha] are regulated by a common oxygen sensor , Impact of reactive oxygen species on the expression of adhesion molecules in vivo , Mini sensing chip for point-of-care acute myocardial infarction diagnosis utilizing micro-electro-mechanical system and nano-technology , A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics" , Zymogen protein C concentrate for safer heterozygote surgery, "I am a guinea pig!" , Steady state redox levels in cytochrome oxidase : relevance for in vivo near infrared spectroscopy (NIRS) , Bicuculline-induced seizures : a challenge for optical and biochemical modeling of the cytochrome oxidase CUa NIRS signal , A method to calculate arterial and venous saturation from near infrared spectroscopy (NIRS) , Development of a dynamic test phantom for optical topography , Numerical simulation of oxygen transport in cerebral tissue , Non-invasive estimation of metabolic flux and blood flow in working muscle : effect of blood-tissue distribution , Oxygen extraction index measured by near infrared spectroscopy : a parameter for monitoring tissue oxygenation? , Non-invasive measurement of the superficial cortical oxygen partial pressure , One sensor fits all : a new approach in monitoring brain physiology , Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue , Myocardial capillary net and blood constituents in streptozotocin (STZ- )-induced diabetic rats , Effects of proinsulin C-peptide on oxygen transport uptake and utilization in insulinopenic diabetic subjects : a review , Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging , Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney , Iodinated contrast media decrease renomedullary blood flow : a possible cause of contrast media-induced nephropathy , C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats , Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents , Prognostic potential of the pre-therapeutic tumor oxygenation status , Histological basis of MR/optical imaging of human melanoma mouse xenografts spanning a range of metastatic potentials , The relationship between vascular oxygen distribution and tissue oxygenation , Intraoperative measurement of colonic oxygenation during bowel resection , Quantifying tumour hypoxia by PET imaging : a theoretical analysis , New measurements for assessment of impaired cerebral autoregulation using near-infrared spectroscopy , Single shot T₁p magnetic resonance imaging of metabolically generated water in vivo , Brain tissue oxygen consumption and supply induced by neural activation : determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex , Brain oxygen balance under various experimental pathophysiological conditions , Ketones suppress brain glucose consumption , False positives in functional near-infrared topography , Relationship between brain tissue haemodynamics, oxygenation, and metabolism in the healthy human adult brain during hyperoxia and hypercapnea , Use of a Codman microsensor intracranial pressure probe : effects on near infrared spectroscopy measurements and cerebral hemodynamics in rats , Effect of severe hypoxia on prefrontal cortex and muscle oxygenation responses at rest and during exhaustive exercise

Additional Edition: ISBN 9780387859972

Additional Edition: Buchausg. u.d.T. Oxygen transport to tissue ; 30 New York, NY : Springer, 2009 ISBN 9780387859972

Language: English

Subjects: Biology

Keywords: Sauerstofftransport ; Gewebestoffwechsel ; Sauerstofftransport ; Gewebestoffwechsel ; Konferenzschrift

DOI: 10.1007/978-0-387-85998-9

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387775746

Series Statement: Advances in Experimental Medicine and Biology 624

Content: The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment

Note: Includes bibliographical references and index , CONTENTS; 1. SUNLIGHT, UV-RADIATION, VITAMIN D AND SKIN CANCER: HOW MUCH SUNLIGHT DO WE NEED?; Abstract; Prehistorical and Historic Perspectives; Photoproduction of Vitamin D3; Factors Controlling Cutaneous Vitamin D Synthesis; Sources and Metabolism of Vitamin D; Role of Vitamin D in the Prevention of Chronic Diseases; Vitamin D Deficiency Pandemic; Sunlight, Vitamin D and the Skin Cancer Conundrum; Conclusion; 2. SOLAR ULTRAVIOLET IRRADIANCE AND CANCER INCIDENCE AND MORTALITY; Introduction; Cancer; Other Diseases for Which Solar UVB and Vitamin D Are Beneficial/Protective , Summary and Conclusion3. VITAMIN D STATUS AND CANCER INCIDENCE AND MORTALITY; Introduction; Ecologic Studies of Sun Exposure; Case-Control and Cohort Studies of Sun Exposure; Prospective Studies of Circulating 25(OH)vitamin D and Cancer Risk; Studies of Vitamin D Intake; Randomized Trial of Vitamin D Intake and Colorectal Cancer; Solar Radiation, Vitamin D and Survival Rate of Colon Cancer; Vitamin D and Cancer Rates in United States Black Men; Synthesis of Evidence Regarding Sun Exposure, Vitamin D and Cancer Incidence and Mortality; Implications for Future Research , 4. SUN EXPOSURE AND CANCER SURVIVAL IN NORWAY: CHANGES IN THE RISK OF DEATH WITH SEASON OF DIAGNOSIS AND LATITUDEAbstract; Introduction; Materials and Methods; Dependency of Survival on Season of Diagnosis; Dependency of Survival on Residential Region; Discussion; Conclusions; 5. OPTIMAL SERUM 25-HYDROXYVITAMIN D LEVELS FOR MULTIPLE HEALTH OUTCOMES; Abstract; Introduction; 25(OH)D Levels and Bone Health; 25(OH)D and Lower Extremity Function; 25(OH)D and Dental Health; 25(OH)D and Cancer Incidence and Mortality; Vitamin D Intake Needed to Achieve Optimal 25(OH)D Levels , Adding Calcium to Vitamin DDiscussion; 6. ULTRAVIOLET EXPOSURE SCENARIOS: RISKS OF ERYTHEMA FROM RECOMMENDATIONS ON CUTANEOUS VITAMIN D SYNTHESIS; Abstract; Introduction; Differences between Vitamin D Synthesis and Erythema; Implications for UV Exposure; Assessing the Erythema Risks of Exposures for Vitamin D Synthesis; Public Health and Personal Choice; 7. AT WHAT TIME SHOULD ONE GO OUT IN THE SUN?; Abstract; Introduction; Methods; Results and Discussion; 8. EPIDEMIOLOGY OF MELANOMA AND NONMELANOMA SKIN CANCER-THE ROLE OF SUNLIGHT; Abstract; Introduction; Nonmelanoma Skin Cancer , Sun Exposure and Nonmelanoma Skin CancerMelanoma; Sun Exposure and Melanoma; 9. ULTRAVIOLET RADIATION AND MALIGNANT MELANOMA; Abstract; Introduction; Does UV Radiation Induce CMM?; Materials and Methods; Results and Discussion; 10. SOLAR UV EXPOSURE AND MORTALITY FROM SKIN TUMORS; Abstract; Introduction; Observed Relationships for Nonmelanoma Skin Cancer; Observed Relationships for Cutaneous Melanoma; Potential Mechanisms; Conclusions; 11. HEALTH INITIATIVES FOR THE PREVENTION OF SKIN CANCER; Introduction; Prevention of Skin Cancer; Balanced Messages (Concerning Vitamin D); Conclusion , 12. SUNSCREENS

Additional Edition: ISBN 9780387775739

Additional Edition: Erscheint auch als Druck-Ausgabe Sunlight, vitamin D, and skin cancer New York, NY : Springer Science+Business Media [u.a.], 2008 ISBN 9780387775739

Additional Edition: ISBN 0387775730

Language: English

Subjects: Medicine

Keywords: Hautkrebs ; Vitamin D3 ; Sonnenstrahlung ; Aufsatzsammlung

DOI: 10.1007/978-0-387-77574-6

URL: Volltext

URL: Volltext

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387782256

Series Statement: Advances in Experimental Medicine and Biology 627

Note: Includes bibliographical references and index

Additional Edition: ISBN 9780387782249

Additional Edition: Buchausg. u.d.T. Transgenesis and the management of vector-borne disease Austin, Tex. : Landes Bioscience, 2008 ISBN 9780387782249

Additional Edition: ISBN 0387782249

Language: English

Subjects: Biology , Medicine

Keywords: Insekten ; Krankheitsübertragung ; Transgener Organismus ; Infektionskrankheit ; Prävention

DOI: 10.1007/978-0-387-78225-6

URL: Volltext

URL: Volltext

URL: Cover

UID:

Format: Online-Ressource (digital)

ISBN: 9780387775708

Series Statement: Advances In Experimental Medicine And Biology 625

Note: Includes bibliographical references and index

Additional Edition: ISBN 9780387775692

Additional Edition: Buchausg. u.d.T. Drug targets in kinetoplastid parasites New York, NY : Springer Science+Business Media LLC, 2008 ISBN 9780387775692

Additional Edition: ISBN 0387775692

Language: English

Subjects: Chemistry/Pharmacy , Medicine

Keywords: Leishmania ; Trypanosomen ; Kinetoplastida ; Kinetoplasten-DNS ; Pharmakotherapie ; Antiparasitäres Mittel ; Aufsatzsammlung

DOI: 10.1007/978-0-387-77570-8

URL: Volltext

URL: Volltext

URL: Cover