In:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 20, No. 6 ( 2000-11), p. 715-721
Kurzfassung:
To determine the influence of an elevated body mass index (BMI) on cardiovascular outcomes and survival in peritoneal dialysis (PD) patients. Design Prospective, observational study of a prevalent PD cohort at a single center. Setting Tertiary care institutional dialysis center. Patients The study included all patients with a BMI of at least 20 who had been receiving PD for at least 1 month as of 31 January 1996 ( n = 43). Patients were classified as overweight [BMI 〉 27.5; mean ± standard error of mean (SEM): 32.1 ± 1.1; n = 14] or normal weight (BMI 20 – 27.5; mean ± SEM: 23.8 ± 0.4; n = 29). Outcome Measures Patient survival and adverse cardiovascular events (myocardial infarction, congestive cardiac failure, cerebrovascular accident, and symptomatic peripheral vascular disease) were recorded over a 3-year period. Results At baseline, no significant differences were seen between the groups in clinical, biochemical, nutritional, or echocardiographic parameters, except for a lower dietary protein intake (0.97 ± 0.10 g/kg/day vs 1.44 ± 0.10 g/ kg/day, p = 0.004) and a higher proportion of well-nourished patients by subjective global assessment (100% vs 72%, p 〈 0.05) in the overweight group. After 3 years of follow-up, 29% of overweight patients and 69% of normal-weight patients had died ( p 〈 0.05). Using a Cox proportional hazards model, a BMI greater than 27.5 was shown to be an independent positive predictor of patient survival, with an adjusted hazard ratio (HR) of 0.09 [95% confidence interval (CI): 0.01 – 0.85; p 〈 0.05]. However, being overweight did not significantly influence myocardial infarction-free survival (adjusted HR: 0.33; 95% CI: 0.07 – 1.48; p = 0.15) or combined adverse cardiovascular event-free survival (adjusted HR: 0.67; 95% CI: 0.23 – 1.93; p = 0.46). Conclusions Obesity conferred a significant survival advantage in our PD population. Obese patients should therefore not be discouraged from receiving PD purely on the basis of BMI. Moreover, maintaining a higher-than-average BMI to preserve “nutritional reserve” may help to reduce the mortality and morbidity rates associated with PD.
Materialart:
Online-Ressource
ISSN:
0896-8608
,
1718-4304
DOI:
10.1177/089686080002000623
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2000
ZDB Id:
2075957-5
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