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  • SAGE Publications  (3)
  • Lang, Wilfried  (3)
  • Schillinger, Martin  (3)
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  • SAGE Publications  (3)
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  • 1
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 8, No. 6 ( 2001-12), p. 539-546
    Abstract: To assess the impact of learning on the rate of success and complications of carotid stenting in a single-center, one-operator series and prospectively follow a patient cohort with regard to restenosis. Methods: In 303 patients (mean age 70 ± 8.8 years), 320 internal carotid arteries (ICA) were treated with carotid stenting for stenoses ≥70%. Four groups of 80 consecutive interventions were compared with regard to primary technical success and periprocedural complications. Stent patency in follow-up was assessed using duplex scanning. Results: Stenting was successful in 298 (93%) arteries. The combined neurological complications (transient ischemic attacks and all strokes) and 30-day death rate was 8.2% (n = 25), but the all stroke and 30-day death rate was 3.0% (n = 9). A significant reduction in the frequency of neurological complications after the initial 80 interventions was observed (p = 0.03), but technical success was not appreciably improved with increasing experience thereafter. Over a median 12 months (interquartile range 6 to 24), cumulative patency rates were 91%, 90%, and 91% at 6, 12, and 36 months, respectively. Conclusions: Elective carotid stenting can be performed with excellent technical success, an acceptable frequency of periprocedural complications, and good intermediate-term patency. However, our findings suggest that a larger number of interventions should be performed to overcome the negative effects of the initial learning phase.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2049858-5
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2003
    In:  Journal of Endovascular Therapy Vol. 10, No. 5 ( 2003-10), p. 851-859
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 10, No. 5 ( 2003-10), p. 851-859
    Abstract: To investigate the frequency of and risk factors for hypotension and bradycardia in response to elective carotid stenting and their association with neurological complications. Methods: A retrospective analysis was conducted of 471 patients (321 men; median age 72 years, interquartile range 64–77) who underwent elective carotid artery stenting without cerebral protection for high-grade ( 〉 70%) symptomatic (n = 147) or asymptomatic (n=324) internal carotid artery stenosis at a single center. Frequency and potential risk factors for severe hypotension (systolic blood pressure 〈 80 mmHg) or bradycardia (heart rate 〈 50 bpm) were studied. Results: Thirty-four (7%) patients had severe hypotension (n=23), bradycardia (n=2), or both (n=9) despite routine premedication with atropine and adequate fluid balance. Intravenous catecholamines (dopamine) were necessary in 8 patients with prolonged hypotension; none of the patients with bradycardia needed pacemaker support. Neurological complications (transient ischemic attack, minor stroke, major stroke, death) occurring in 33 (7%) patients were not significantly associated with hemodynamic instability (4/34 [12%] versus 29/437 [7%] , p = 0.26). Age 〉 77 years (fourth quartile; OR 6.40, 95% CI 1.80 to 22.78, p=0.004) and coronary artery disease (OR 2.81, 95% CI 1.29 to 6.14, p=0.010) were associated with an increased adjusted risk for hypotension or bradycardia. Conclusions: Hemodynamic instability due to hypotension and bradycardia in response to carotid artery stenting occurs in a relatively low proportion of patients. Elderly patients and those with coronary artery disease are at highest risk. Although the rate of neurological complications was not significantly increased in patients with hemodynamic instability, the higher frequencies of neurological complications in these patients admonish us to be careful.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2049858-5
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2002
    In:  Journal of Endovascular Therapy Vol. 9, No. 5 ( 2002-10), p. 559-565
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 9, No. 5 ( 2002-10), p. 559-565
    Abstract: To assess the impact of age on technical success and complications of carotid stenting in a prospective single-center cohort study. Methods: One hundred eleven consecutive patients (74 men; median age 70 years) with ≥70% symptomatic (n=33) or ≥90% asymptomatic (n=78) internal carotid artery (ICA) stenosis underwent carotid artery stent implantation. Primary technical success and periprocedural complications were compared in patients aged 〉 75 years (n=28) to patients 〈 75 years (n=83). Results: Patient groups below and above 75 years compared well with respect to baseline demographic and clinical data. Successful stenting was achieved in 108 (97%) patients. The combined neurological complication rate was 7% (n=8), with 1 (1%) major stroke, 1 (1%) minor stroke, and no 30-day mortality. Technical angiographic complications occurred in 8 (7%) patients. No significant differences between patients 〉 75 years and those 〈 75 years were observed for primary success rates (100% [28/28] versus 96% [80/83] ; p=0.8), overall complications (14% [4/28] versus 16% [13/83] ; p=1.0), neurological complications (7% [2/28] versus 7% [6/83] ; p=1.0), or technical complications (7% [2/28] versus 4% [3/83] ; p=0.6). Conclusions: Elective carotid stenting can be performed safely in older patients with several comorbidities. Patient age does not seem to be an independent risk factor for poor outcome after endovascular treatment of internal carotid artery stenosis. Both Drs. Ahmadi and Schillinger contributed equally to the study.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2049858-5
    Library Location Call Number Volume/Issue/Year Availability
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