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  • European Respiratory Society (ERS)  (2)
  • Koletzko, Sibylle  (2)
Type of Medium
Publisher
  • European Respiratory Society (ERS)  (2)
Language
Years
  • 1
    Online Resource
    Online Resource
    European Respiratory Society (ERS) ; 2016
    In:  European Respiratory Journal Vol. 48, No. 2 ( 2016-08), p. 428-440
    In: European Respiratory Journal, European Respiratory Society (ERS), Vol. 48, No. 2 ( 2016-08), p. 428-440
    Abstract: In lung disease, physical activity improves lung function and reduces morbidity. However, healthy populations are not well studied. We estimate the relationship between spirometric indices and accelerometric physical activity in lung-healthy adolescents. 895 nonsmoking German adolescents without chronic lung disease (45% male, mean± sd age 15.2±0.26 years) from the GINIplus and LISAplus cohorts completed questionnaires, spirometry, 7-day accelerometry and an activity diary. Physical activity was measured as minutes, quintiles and regularity of daily moderate, vigorous and moderate-to-vigorous physical activity (MVPA), participation in sport and active commuting to school. Primary outcomes were forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC and forced expiratory flow at 25–75% of FVC; they were separately correlated with physical activity and adjusted for confounders of respiratory function, including early-life exposures. Adolescents averaged 40 min MVPA per day, typical for European youth. 79% participated in sports and 51% commuted actively. An association was suggested between 3% higher FVC (∼100 mL) and either extreme MVPA quintile or percentage of days with 〉 30 min MVPA (p 〈 0.05). However, after Bonferroni correction all associations between spirometry, active lifestyle and physical activity were nonsignificant. Spirometric indices were not significantly associated with active lifestyle or measures of activity in lung-healthy adolescents after adjustment for confounding and multiple-comparison artefacts.
    Type of Medium: Online Resource
    ISSN: 0903-1936 , 1399-3003
    Language: English
    Publisher: European Respiratory Society (ERS)
    Publication Date: 2016
    detail.hit.zdb_id: 2834928-3
    detail.hit.zdb_id: 1499101-9
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    In: European Respiratory Journal, European Respiratory Society (ERS), Vol. 49, No. 4 ( 2017-04), p. 1601804-
    Abstract: Vitamin D plays a role in the development of the immune system and the lung, as well as in airway remodelling. Therefore, this study investigated the association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and spirometric lung function parameters at age 15 years. In the German birth cohorts GINIplus and LISAplus, lung function testing by spirometry and 25(OH)D measurements were performed during the 15-year follow-up examinations. Valid lung function measurements pre- and/or post-bronchodilation and serum 25(OH)D concentrations, which were adjusted for the date of blood sampling to account for seasonal variability, were available for 2607 adolescents. Associations between 25(OH)D concentrations and spirometric parameters were analysed using generalised additive models adjusted for confounding factors. Serum 25(OH)D concentrations were significantly associated with forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and FEV 1 /FVC measured before bronchodilation after adjustment for potential confounders: FEV 1 increased by 10 mL (95% CI 2–17), FVC by 20 mL (95% CI 12–28) and FEV 1 /FVC decreased by 0.177% (95% CI −0.286 to −0.067) per 10 nmol·L −1 increase in 25(OH)D concentrations. Flow rates (forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF 25 , FEF 50 , FEF 75 ) and mean flow rate between 25 and 75% of FVC (FEF 25–75 )) were not associated with vitamin D. Similar associations were observed for lung function parameters measured after bronchodilation. Vitamin D concentrations are positively associated with volume-related lung function parameters pre- and post-bronchodilation, suggesting structural changes in peripheral airways.
    Type of Medium: Online Resource
    ISSN: 0903-1936 , 1399-3003
    Language: English
    Publisher: European Respiratory Society (ERS)
    Publication Date: 2017
    detail.hit.zdb_id: 2834928-3
    detail.hit.zdb_id: 1499101-9
    Library Location Call Number Volume/Issue/Year Availability
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