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  • SAGE Publications  (18)
  • 2010-2014  (18)
  • 1
    In: Biological Research For Nursing, SAGE Publications, Vol. 15, No. 4 ( 2013-10), p. 382-389
    Abstract: The CYP2D6 gene encodes for an enzyme that is involved in the metabolism of more than 25% of all medications, including many opioids and antiemetics. It may contribute to the risk of postoperative nausea and vomiting (PONV), a common surgical complication. However, little research has been conducted in this area. The purpose of this study was to explore the association of CYP2D6 genotypes with PONV in adult surgical trauma patients. Data from 112 patients (28% female) with single extremity fractures, aged 18–70 years, were analyzed. PONV was defined as present if patients reported nausea, were observed vomiting, or received medication for PONV. Saliva samples collected for DNA extraction and Taqman ® allele discrimination and quantitative real time polymerase chain reaction (qRT-PCR) were used to collect genotype data that were then used to assign CYP2D6 phenotype classification. The incidence of PONV was 38% in the postanesthesia care unit and increased to 50% when assessed at 48 hr. CYP2D6 classification results were 7 (6%) poor metabolizers, 34 (30%) intermediate metabolizers, and 71 (63%) extensive metabolizers. No ultrarapid metabolizers were identified. Patients who were classified as poor metabolizers had less PONV and higher pain scores. Gender and history of PONV, but not smoking, were also significant risk factors. Findings suggest variability in CYP2D6 impacts susceptibility to PONV.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2070503-7
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Journal of Service Research Vol. 16, No. 4 ( 2013-11), p. 549-563
    In: Journal of Service Research, SAGE Publications, Vol. 16, No. 4 ( 2013-11), p. 549-563
    Abstract: Success rates of behavior change counseling programs (e.g., weight loss, smoking cessation, and debt management), where consumers seek to overcome their destructive habits and enhance well-being, are very low. Characterized by extended and complex service encounters, the providers of these programs face the challenge of gaining consumers’ compliance to adhere to the programs’ requirements and turning these consumers into effective co-producers of the service outcomes. This study investigates the process of customer organizational socialization in these programs, how it may promote co-production behaviors, and thus enhance consumers’ well-being as well as satisfaction with the organization. The context of debt management programs is used to test the model. Data were obtained from 364 clients of a major credit counseling organization in the United States. The results reveal the differential effects of three aspects of socialization (role clarity, task mastery, and goal congruence) on three different types of consumer co-production behaviors (compliance, individual initiative, and civic virtue). Overall, compliance has the greatest contribution to well-being, while both compliance and individual initiative enhance satisfaction with the organization. Furthermore, consumers with a higher or lower ongoing dependence on the organization have different routes to well-being, with the high-dependence group relying on individual initiative, and the low-dependence group favoring compliance. This study contributes to the literature of co-production, organizational socialization, and consumers’ well-being by showing how these three streams are connected. Managerial and policy implications focus on the need for these organizations to include efforts to ensure that consumers are effectively socialized into the program.
    Type of Medium: Online Resource
    ISSN: 1094-6705 , 1552-7379
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2020788-8
    SSG: 3,2
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Global Spine Journal Vol. 3, No. 4 ( 2013-12), p. 265-271
    In: Global Spine Journal, SAGE Publications, Vol. 3, No. 4 ( 2013-12), p. 265-271
    Abstract: Systematic review. Objective We assessed the current state of spine registries by collecting spine trauma data and assessing their compliance to defined registry standards of being clinical quality. We ascertained if these registries collected spinal cord injury data alone or with spine column trauma data. Methods A systematic review was performed using MEDLINE and Embase databases for articles describing dedicated spinal cord and spine column databases published between January 1990 and April 2011. Correspondence with these registries was performed via e-mail or post. When no correspondence was possible, the registries were analyzed with best information available. Results Three hundred eight full-text articles were reviewed. Of 41 registries identified, 20 registries fulfilled the criteria of being clinical quality. The main reason for failure to attain clinical quality designation was due to the unavailability of patient outcomes. Eight registries collected both spine column and spinal cord injury data with 33 collecting only traumatic spinal cord injury data. Conclusion There is currently a paucity of clinical quality spine trauma registries. Clinical quality registries are important tools for demonstrating trends and outcomes, monitoring care quality, and resolving controversies in the management of spine trauma. An international spine trauma data set (containing both spinal cord and spine column injury data) and standardized approach to recording and analysis are needed to allow international multicenter collaboration and benchmarking.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2648287-3
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  Journal of Feline Medicine and Surgery Vol. 14, No. 12 ( 2012-12), p. 863-870
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 14, No. 12 ( 2012-12), p. 863-870
    Abstract: This study evaluated the types of items owners consider important to their cats’ quality of life (QoL). We hypothesized that items contributing to QoL in cats are predominantly items requiring mobility. The objectives of the study were to describe the types of items considered important by owners for their cats’ QoL; to describe the proportion of these items that involve mobility; to evaluate what patient factors, including severity of degenerative joint disease (DJD), affect this distribution; and to evaluate whether the proportion of QoL items involving mobility chosen by owners is different in cats presenting for a DJD study compared with a randomly selected population. A total of 830 client-generated items were evaluated. Regardless of DJD status, 40% of items listed by owners involved mobility, while 60% were ‘inactive’ items, rejecting our hypothesis. This highlights the need to assess non-active items that owners consider to constitute QoL to fully assess the impact of diseases like DJD and, therefore, the success of therapeutic interventions.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Journal of Feline Medicine and Surgery Vol. 16, No. 9 ( 2014-09), p. 727-735
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 16, No. 9 ( 2014-09), p. 727-735
    Abstract: Clinical trials are frequently hindered by difficulties in recruiting eligible participants, increasing the timeline and limiting generalizability of results. In veterinary medicine, where proxy enrollment is required, no studies have detailed what factors influence owner participation in clinical trials involving cats. We aimed to investigate these factors through a survey of owners at first opinion practices. Protocol: The survey was designed using feedback from a pilot study and input from clinical researchers. Owners were asked demographic questions and whether they would, would not, or were unsure about participating in a clinical trial with their cat. They then ranked the importance and influence of various factors on participation using a five-point Likert-type scale, and incentives from most to least encouraging. A total of 413 surveys were distributed to cat owners at four hospitals, two feline-only and two multi-species; 88.6% were completed. Data for importance and influence factors as well as incentive rankings were analyzed overall, and by hospital type, location and whether owners would consider participating. Findings: The most influential factors were trust in the organization, benefit to the cat and veterinarian recommendation. Importance and influence factors varied by willingness to participate. Ranked incentives were not significantly different across groups, with ‘Free Services’ ranked highest. Relevance: This study provides a first look at what factors influence participation in clinical trials with cats. Given the importance placed in the recommendation of veterinarians, continued work is needed to determine veterinarian-related factors affecting clinical trial participation. The results provide guidance towards improved clinical trial design, promotion and education.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2011
    In:  Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology Vol. 225, No. 7 ( 2011-07), p. 617-626
    In: Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, SAGE Publications, Vol. 225, No. 7 ( 2011-07), p. 617-626
    Abstract: The loading capacity of metallic journal-bearing materials is investigated in this study under lubricated conditions using a ring-on-disc test configuration. The materials investigated are AlSn20Cu, AlSn40, SnSb7.5Cu3.5, PbSn18Cu2, and AlSn20Cu-Sputter, mated against polished steel counterparts. The loading capacity for different sliding speeds ranging from 0.14 to 2.82 m/s was determined using seizure test procedure. Microscopic analysis of the tested specimen was carried out and the load limits were plotted in pv-diagrams. The results show that for tribomaterials with a load-bearing matrix, as in AlSn-based materials, an increase in the content of soft phase improves fault tolerance. It also increases the loading capacity at low speeds, where adhesion effects dominate. Materials composed of a soft matrix such as Sn- or Pb-based material possess excellent sliding performance but fail due to thermo-mechanical breakdown.
    Type of Medium: Online Resource
    ISSN: 1350-6501 , 2041-305X
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2032767-5
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  • 7
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 16, No. 6 ( 2014-06), p. 465-472
    Abstract: Chronic kidney disease (CKD) and degenerative joint disease are both considered common in older cats. Information on the co-prevalence of these two diseases is lacking. This retrospective study was designed to determine the prevalence of CKD in two cohorts of cats: cats randomly selected from four evenly distributed age groups (RS group) and cats recruited for degenerative joint disease studies (DJD group), and to evaluate the concurrence of CKD and DJD in these cohorts. The RS group was randomly selected from four age groups from 6 months to 20 years, and the DJD group comprised cats recruited to four previous DJD studies, with the DJD group excluding cats with a blood urea nitrogen and/or serum creatinine concentration 〉 20% (the upper end of normal) for two studies and cats with CKD stages 3 and 4 for the other two studies. The prevalence of CKD in the RS and DJD groups was higher than expected at 50% and 68.8%, respectively. CKD was common in cats between 1 and 15 years of age, with a similar prevalence of CKD stages 1 and 2 across age groups in both the RS and DJD cats, respectively. We found significant concurrence between CKD and DJD in cats of all ages, indicating the need for increased screening for CKD when selecting DJD treatments. Additionally, this study offers the idea of a relationship and causal commonality between CKD and DJD owing to the striking concurrence across age groups and life stages.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Foot & Ankle Specialist Vol. 6, No. 2 ( 2013-04), p. 119-124
    In: Foot & Ankle Specialist, SAGE Publications, Vol. 6, No. 2 ( 2013-04), p. 119-124
    Abstract: Introduction. Lawn mower injuries occur frequently in the United States and oftentimes result in extensive trauma to the lower extremities. These injuries can be quite devastating and cause there to be loss of function and amputation. The purpose of this study was to determine if there are specific factors that would help determine the best treatment protocol, patient outcomes, and prognosis after lawn mower injury to the foot and ankle. Material and Methods. A retrospective review of medical records was performed on all patients treated at a university level 1 trauma center from 2000 to 2010. Only subjects 18 years or older who sustained an injury below the level of the knee were included for review. Results. Seventy-three patients were included in this review. The results revealed that patients who developed a complication were significantly older than the group of patients without complications ( P = .03). Digits were found to be injured most often but the odds of developing a complication were much higher if these injuries involved the plantar foot, dorsal foot, or ankle. Interestingly, patients on prolonged antibiotic therapy had a significantly higher risk of developing complications. The presence of comorbidities significantly increased the risk of complication ( P = .008); the greatest risk factors were cardiovascular disease ( P = .001) and diabetes ( P = .06). Discussion. The authors present the largest cohort of lawn mower injuries in the medical literature, which demonstrates that factors such as age, location of injury, and the presence of comorbidities influence the outcome and increase the risk of injury to the foot and ankle. These results may be useful in determining the best treatment plan possible for patients with these severe injuries. Levels of Evidence: Therapeutic, Level IV, Retrospective case series
    Type of Medium: Online Resource
    ISSN: 1938-6400 , 1938-7636
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2411886-2
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Journal of Travel Research Vol. 53, No. 3 ( 2014-05), p. 296-306
    In: Journal of Travel Research, SAGE Publications, Vol. 53, No. 3 ( 2014-05), p. 296-306
    Abstract: Data analysts in industry and academia make heavy use of market segmentation analysis to develop tourism knowledge and select commercially attractive target segments. Within academic research alone, approximately 5% of published articles use market segmentation. However, the validity of data-driven market segmentation analyses depends on having available a sample of adequate size. Moreover, no guidance exists for determining what an adequate sample size is. In the present simulation study using artificial data of known structure, the impact of the difficulty of the segmentation task on the required sample size is analyzed in dependence of the number of variables in the segmentation base. Under all simulated data circumstances, a sample size of 70 times the number of variables proves to be adequate. This finding is of substantial practical importance because it will provide guidance to data analysts in academia and industry who wish to conduct reliable and valid segmentation studies.
    Type of Medium: Online Resource
    ISSN: 0047-2875 , 1552-6763
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2036634-6
    SSG: 14
    SSG: 3,2
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  • 10
    In: Biological Research For Nursing, SAGE Publications, Vol. 15, No. 3 ( 2013-07), p. 309-317
    Abstract: Previous studies have associated mu-opioid receptor ( OPRM1) genotype with pain and analgesia responses in postoperative and patient populations. This study investigates the role of catechol-O-methyltransferase ( COMT) and OPRM1 genotypes in acute postoperative pain scores, opioid use, and opioid-induced sedation after surgical procedures for orthopedic trauma in an otherwise healthy patient population. Verbal pain/sedation scores, opioid use, and physiologic responses in the immediate postoperative period were examined for association with genetic variants in Caucasians genotyped for OPRM1 single nucleotide polymorphisms (SNPs) A118G and C17T and COMT SNPs. The OPRM1 A118G genotype was associated with patients’ postoperative Numerical Pain scale (NPS) ratings at 15 min in the postanesthesia care unit (PACU) ( p = .01) and patients' sedation scores at 15 min in the PACU ( p = .02). COMT genotype (rs4818) was associated with opioid consumption in the first 45 min in the PACU ( p = .04). NPS ratings at 45 min were also higher in the group of patients with A/A genotype of rs4680 than in patients with the other two genotypes at this SNP ( p = .03). Our haplotype trend analysis identified a COMT haplotype “GCGG” significantly associated with NPS at 15 min ( p = .0013), amount of opioids consumed in the first 45 min ( p = .0024), and heart rate at 45 min in the PACU ( p = .017). The results indicate that genetic variations in COMT contribute to the acute postoperative pain and analgesia responses and physiologic responses in this group of otherwise healthy postoperative orthopedic trauma patients.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2070503-7
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