In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 162, No. 2 ( 1993-02), p. 175-182
Abstract:
Of 219 elderly patients with a major depressive disorder (meeting RDC), 69 recovered sufficiently and consented to enter a two-year double-blind placebo-controlled trial of dothiepin. Survival analysis revealed that dothiepin reduced the relative risk of relapse by two and a half times. Past but not current serious physical illness was also associated with a favourable outcome, whereas a prolonged index depressive illness trebled the relative risk of relapse. In the light of previous research on prognosis it is suggested that elderly persons who recover from a major depressive illness should continue with antidepressant medication for at least two years, if not indefinitely.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.162.2.175
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
1993
detail.hit.zdb_id:
2021500-9
Bookmarklink