In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 123, No. 10 ( 2020-05-28), p. 1187-1200
Abstract:
B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients ( n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5’-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) ( r –0·33, P linear 〈 0·0001), serum amyloid A (SAA) ( r –0·23, P linear = 0·003), IL-6 ( r –0·39, P linear 〈 0·0001), IL-8 ( r –0·20, P linear = 0·02) and TNF α ( r –0·12, P linear = 0·045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP ( r –0·14), SAA ( r –0·14) and TNF α ( r –0·15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 ( r 0·27, P linear 〈 0·0001), and pABG was positively correlated with IL-8 ( r 0·21, P linear 〈 0·0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.
Type of Medium:
Online Resource
ISSN:
0007-1145
,
1475-2662
DOI:
10.1017/S0007114520000422
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2020
detail.hit.zdb_id:
2016047-1
SSG:
12
SSG:
21
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