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  • Canadian Science Publishing  (110)
  • 1965-1969  (110)
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  • Canadian Science Publishing  (110)
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  • 1965-1969  (110)
Year
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  • 1
    Online Resource
    Online Resource
    EFFECTS OF AMODIAQUIN AND QUINIDINE ON CARDIAC CONDUCTION
    Canadian Science Publishing ; 1965
    In:  Canadian Journal of Physiology and Pharmacology Vol. 43, No. 1 ( 1965-01-01), p. 29-38
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 43, No. 1 ( 1965-01-01), p. 29-38
    Abstract: The effects of the antiarrhythmia agents amodiaquin and quinidine on conduction times through the atrium and the specialized conducting tissue to the ventricular myocardium have been determined from records obtained with needle electrodes suitably placed in isolated blood perfused dog hearts. Quinidine slowed conduction through each portion of the total pathway when very low concentrations were infused but had a preferential depressant effect on atrial conduction at slightly higher concentrations. Amodiaquin slowed conduction in the atrioventricular node to a greater extent than in the other parts of the common pathway at all concentrations tested. The major effect of each drug on extra-atrial conduction occurred at the atrioventricular node and at the Purkinje–myocardial junction. Amodiaquin did not induce bigeminal rhythm in the isolated heart.
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/y65-004
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1965
    detail.hit.zdb_id: 2004356-9
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  • 2
    Online Resource
    Online Resource
    A ROLE OF BLOOD PRESSURE IN THE EFFECT OF METHOXAMINE ON CARDIAC CONDUCTION
    Canadian Science Publishing ; 1967
    In:  Canadian Journal of Physiology and Pharmacology Vol. 45, No. 5 ( 1967-09-01), p. 919-921
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 45, No. 5 ( 1967-09-01), p. 919-921
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/y67-108
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1967
    detail.hit.zdb_id: 2004356-9
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  • 3
    Online Resource
    Online Resource
    THE RELATIVE INFLUENCE OF NERVOUS CONTROL AND OF LOCAL WARMING ON ARTERIOLAR MUSCLE DURING INDIRECT VASODILATATION
    Canadian Science Publishing ; 1967
    In:  Canadian Journal of Physiology and Pharmacology Vol. 45, No. 1 ( 1967-01-01), p. 83-91
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 45, No. 1 ( 1967-01-01), p. 83-91
    Abstract: The relative importance of the inhibition of vasoconstrictor nerves and of concomitant local warming in the production of indirect vasodilatation was investigated in terms of the decrease in critical opening pressure (COP) of digital vessels during body heating. The COP of vessels in a finger of each hand was measured when both hands were kept at about 21 °C during body heating in control experiments and when one of the hands was allowed to warm in air in test experiments. In eight control experiments the COP's of vessels in both fingers fell together. In 25 test experiments they fell together in both fingers until the hand in air began to warm. The COP then fell more rapidly and farther in the finger which warmed. In the test experiments the difference between the reductions in COP in the two fingers was attributed to the effect of local warming. The total reduction in the hand which was prevented from warming was ascribed to inhibition of neurogenic smooth muscle tone. On the average, local warming reduced the COP by 1.3 mm Hg for each increase of 1 °C. Warming occurred when the COP was reduced to about 25 to 35 mm Hg. However, much higher values of COP can exist in the constricted subject. Therefore the initial smooth muscle constricting force may have to be greatly reduced by inhibition of vasoconstrictor nerves before appreciable warming occurs. Then local warming may play an important role in determining the degree of vasodilatation that occurs.
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/y67-009
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1967
    detail.hit.zdb_id: 2004356-9
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  • 4
    Online Resource
    Online Resource
    The effect of repeated cold exposure of the hand on the reactivity of digital vessels
    Canadian Science Publishing ; 1969
    In:  Canadian Journal of Physiology and Pharmacology Vol. 47, No. 3 ( 1969-03-01), p. 261-265
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 47, No. 3 ( 1969-03-01), p. 261-265
    Abstract: One hand of each of 10 subjects was immersed in stirred water at 4 °C for 1 h per day, 5 days per week, for 3 weeks, to produce local acclimatization to cold. The opposite hand was immersed at the same time in water at 32 °C. The reactivity of digital vessels in a finger of each hand was measured as the increase in the critical opening pressure of the vessels in response to an intravenous infusion of noradrenaline at 2 and 5 μg/min. The reactivity of digital vessels in the test hand was compared with that in the control hand both before and after the repeated cold exposure of the test hand to see whether the cold exposure altered the reactivity of vessels in the test hand relative to that in the control hand. No evidence of such a relative change was obtained. Resting blood flow at 21 and 32 °C in the test hand was compared with that in the control hand both before and after the repeated cold exposure. No change in the relative flow rate in the two hands was observed as a result of the cold exposure. Roentgen studies of the hands did not reveal any effect of the repeated cold exposure on the mineralization of the bones of the hands.
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/y69-047
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1969
    detail.hit.zdb_id: 2004356-9
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  • 5
    Online Resource
    Online Resource
    General Genetics
    Canadian Science Publishing ; 1966
    In:  Canadian Journal of Genetics and Cytology Vol. 8, No. 2 ( 1966-06-01), p. 359-359
    Details
    In: Canadian Journal of Genetics and Cytology, Canadian Science Publishing, Vol. 8, No. 2 ( 1966-06-01), p. 359-359
    Type of Medium: Online Resource
    ISSN: 0008-4093
    URL: Article
    DOI: 10.1139/g66-044
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1966
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  • 6
    Online Resource
    Online Resource
    THE TRANSMISSION OF A HETEROCHROMATIC ISOCHROMOSOME IN LYCOPERSICON ESCULENTUM
    Canadian Science Publishing ; 1965
    In:  Canadian Journal of Genetics and Cytology Vol. 7, No. 2 ( 1965-06-01), p. 296-303
    Details
    In: Canadian Journal of Genetics and Cytology, Canadian Science Publishing, Vol. 7, No. 2 ( 1965-06-01), p. 296-303
    Type of Medium: Online Resource
    ISSN: 0008-4093
    URL: Article
    DOI: 10.1139/g65-041
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1965
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  • 7
    Online Resource
    Online Resource
    INFLUENCE OF TEMPERATURE ON INCOMPATIBLE AND COMPATIBLE POLLEN TUBE GROWTH IN LILIUM LONGIFLORUM
    Canadian Science Publishing ; 1966
    In:  Canadian Journal of Genetics and Cytology Vol. 8, No. 4 ( 1966-12-01), p. 661-664
    Details
    In: Canadian Journal of Genetics and Cytology, Canadian Science Publishing, Vol. 8, No. 4 ( 1966-12-01), p. 661-664
    Type of Medium: Online Resource
    ISSN: 0008-4093
    URL: Article
    DOI: 10.1139/g66-081
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1966
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  • 8
    Online Resource
    Online Resource
    THE STABILIZATION OF HEPATIC GLYCOGEN SYNTHETASE AT 37 °C BY GLUCOSE-6-PHOSPHATE AND ANAEROBIOSIS
    Canadian Science Publishing ; 1966
    In:  Canadian Journal of Biochemistry Vol. 44, No. 5 ( 1966-05-01), p. 591-597
    Details
    In: Canadian Journal of Biochemistry, Canadian Science Publishing, Vol. 44, No. 5 ( 1966-05-01), p. 591-597
    Abstract: The effect of glucose-6-phosphate, anaerobiosis, and mercaptoethanol upon inactivation at 37° of hepatic UDPglucose: glycogen α-4-glucosyltransferase (EC 2.4.1.11) (glycogen synthetase) was studied. A rat liver preparation, consisting of glycogen granules with some microsomal contamination, was used. During the first 20 minutes of aerobic or anaerobic incubation at 37° the activity of the synthetase falls sharply. When 0.01 M glucose-6-phosphate is present initially under aerobic conditions, a transient stabilization of the enzyme activity occurs. Incubation in an atmosphere of nitrogen results in a prolonged stabilization, after the initial decrease of the enzyme activity. Incubation of the enzyme preparation under anaerobic conditions (N 2 ) in the presence of 0.01 M glucose-6-phosphate prevents loss of enzyme activity for the entire 90-minute incubation period. However, most of the added glucose-6-phosphate is hydrolyzed within the first 10 minutes of incubation. The effect of N 2 is reproduced to a large extent by mercaptoethanol, but the effect of these two agents is not additive. It is concluded that inactivation of the enzyme at 37° is partially due to the aerobic oxidation of —SH groups of the enzyme.
    Type of Medium: Online Resource
    ISSN: 0008-4018
    URL: Article
    DOI: 10.1139/o66-071
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1966
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  • 9
    Online Resource
    Online Resource
    Effect of 17α-methyltestosterone on steroid formation by rat adrenal tissue
    Canadian Science Publishing ; 1968
    In:  Canadian Journal of Biochemistry Vol. 46, No. 5 ( 1968-05-01), p. 433-440
    Details
    In: Canadian Journal of Biochemistry, Canadian Science Publishing, Vol. 46, No. 5 ( 1968-05-01), p. 433-440
    Abstract: The addition of 17α-methyltestosterone to rat adrenals suppressed the conversion of 4- 14 C-labeled progesterone and 11-deoxycorticosterone to the corticosteroids, including corticosterone, 18-hydroxy-11-deoxycorticosterone, aldosterone, and more polar substances, such as 18-hydroxycorticosterone. The inhibition depended upon the dose of 17α-methyltestosterone; the formation of substances with the polarity of aldosterone or greater were most sensitive. The 17α-methyltestosterone appears to act as a competitive substrate for the adrenal hydroxylating enzymes because it is itself metabolized to more polar products. The main product, 11β-hydroxy-17α-methyltestosterone, did not appear to inhibit hydroxylation significantly.
    Type of Medium: Online Resource
    ISSN: 0008-4018
    URL: Article
    DOI: 10.1139/o68-065
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1968
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  • 10
    Online Resource
    Online Resource
    Sputtering efficiency of amorphous substances
    Canadian Science Publishing ; 1968
    In:  Canadian Journal of Physics Vol. 46, No. 6 ( 1968-03-15), p. 731-737
    Details
    In: Canadian Journal of Physics, Canadian Science Publishing, Vol. 46, No. 6 ( 1968-03-15), p. 731-737
    Abstract: Sputtering efficiency is denned as the fraction of bombarding ion energy leaving a crystal via sputtering and backscattering. This quantity is calculated for the case of perpendicular incidence on a random medium with plane surface. Use is made of the spatial distribution of deposited energy as calculated by Sanders and the author. In the elastic collision region but above about 1 keV, the sputtering efficiency is predicted to be essentially independent of ion energy and to depend only on the mass ratio. For self-sputtering it should be 2.4% and increase with decreasing ion mass. The predictions appear to be consistent with existing experimental results, but a few direct checks are desirable. Qualitative arguments suggest that, in the case of single crystals, lattice effects with respect to the incoming beam are more pronounced in the sputtering efficiency than in the yield. Reversely, ejection patterns of sputtered energy should reveal less influence of lattice structure than those of sputtered intensity. The latter result is consistent with experiment.
    Type of Medium: Online Resource
    ISSN: 0008-4204 , 1208-6045
    URL: Article
    DOI: 10.1139/p68-090
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 1968
    detail.hit.zdb_id: 2021497-2
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