In:
The Laryngoscope, Wiley, Vol. 126, No. 1 ( 2016-01), p. 254-259
Abstract:
Determine the impact of nasal obstruction on efficacy, success, and adherence of Provent therapy in patients with obstructive sleep apnea (OSA). Study Design Prospective, two‐arm, clinical pilot study at a single clinical site. Methods Patients with OSA who failed continuous positive airway pressure therapy were divided into two treatment arms: arm 1 were patients with no complaints of nasal obstruction and 〈 50% nasal obstruction on exam, and arm 2 were patients with occasional complaints of nasal obstruction and 50% to 80% nasal obstruction on exam. Sleep testing at home was performed prior to the trial and on day 10 of the study with the use of Provent. Results Apnea‐hypopnea index (AHI) decreased significantly from 20.5 ± 14.8 to 11.5 ± 16.6 ( P 〈 .001) in our total patient population. Patients in arm 1 had statistically significant improvement in their AHI (18.1 ± 13.0 to 7.4 ± 10.1, P 〈 .001), oxygen desaturation index (ODI) (16.3 ± 10.8 to 8.2 ± 9.0, P 〈 .001), and minimum oxygen saturation (81.3% ± 6.7% to 86.9% ± 5.6%, P = 0.008) from baseline sleep study to sleep study 2. Patients in arm 2 had improvements in their AHI (23.4 ± 16.6 to 16.5 ± 21.4), ODI (21.5 ± 14.8 to 17.0 ± 16.0) and minimum 0 2 %. However, none of these reached statistical significance. Conclusions In this study, Provent therapy had a high failure rate. Patients without nasal obstruction showed greater improvements using Provent than patients with obstruction. Correction of nasal obstruction may be a useful prerequisite for treatment with Provent. Level of Evidence 2B. Laryngoscope , 126:254–259, 2016
Type of Medium:
Online Resource
ISSN:
0023-852X
,
1531-4995
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2026089-1
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