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  • 1
    Online Resource
    Online Resource
    Gas Exchange during Gas and Liquid Ventilation
    SAGE Publications ; 1996
    In:  Journal of Intensive Care Medicine Vol. 11, No. 6 ( 1996-11), p. 313-325
    Details
    In: Journal of Intensive Care Medicine, SAGE Publications, Vol. 11, No. 6 ( 1996-11), p. 313-325
    Abstract: Liquid Ventilation with perfluorochemicals (PFC) violates many of our long-held assumptions about how the lung functions. However, the technique has been so successful in animal models of lung disease that it is currently being tested in clinical trials for the treatment of infant and acute (“adult”) respiratory distress syndrome in newborns, children, and adults. A common feature of both infant and acute respiratory distress syndromes is an inability of the lung's surfactant system to adequately lower surface tension, leading to regions of atelectasis. Liquid ventilation with PFC appears to ameliorate the disease process by lowering interfacial tension in the lung, opening regions of atelectasis, and improving gas exchange. To understand how gas exchange is successful during liquid ventilation requires careful re-evaluation of the assumptions underlying our current models of gas exchange physiology during normal gas ventilation. These assumptions must then be examined in light of the alterations in pulmonary physiology during liquid ventilation.
    Type of Medium: Online Resource
    ISSN: 0885-0666 , 1525-1489
    URL: Article
    DOI: 10.1177/088506669601100603
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1996
    detail.hit.zdb_id: 2001472-7
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  • 2
    Online Resource
    Online Resource
    CUDA-enabled hierarchical ward clustering of protein structures based on the nearest neighbour chain algorithm
    SAGE Publications ; 2016
    In:  The International Journal of High Performance Computing Applications Vol. 30, No. 2 ( 2016-05), p. 200-211
    Details
    In: The International Journal of High Performance Computing Applications, SAGE Publications, Vol. 30, No. 2 ( 2016-05), p. 200-211
    Abstract: Clustering of molecular systems according to their three-dimensional structure is an important step in many bioinformatics workflows. In applications such as docking or structure prediction, many algorithms initially generate large numbers of candidate poses (or decoys), which are then clustered to allow for subsequent computationally expensive evaluations of reasonable representatives. Since the number of such candidates can easily range from thousands to millions, performing the clustering on standard central processing units (CPUs) is highly time consuming. In this paper, we analyse and evaluate different approaches to parallelize the nearest neighbour chain algorithm to perform hierarchical Ward clustering of protein structures, using both atom-based root mean square deviation (RMSD) and rigid-body RMSD molecular distances on a graphics processing unit (GPU). This leads to a speedup of around one order of magnitude of our CUDA implementation on a GeForce Titan GPU compared to a multi-threaded CPU implementation on a Core-i7 2700. Furthermore, the runtimes compare favourably with ClusCo, another state-of-the-art CUDA-enabled protein structure clustering method, while achieving similar accuracy on the iTasser benchmark dataset. Our implementation has also been incorporated into the Biochemical Algorithms library to allow easy integration into biologists’ workflows.
    Type of Medium: Online Resource
    ISSN: 1094-3420 , 1741-2846
    URL: Article
    DOI: 10.1177/1094342015597988
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2017480-9
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  • 3
    Online Resource
    Online Resource
    Hemicranial Attacks or Permanent Hemicrania — A Sequel of Upper Cervical Root Compression
    SAGE Publications ; 1989
    In:  Cephalalgia Vol. 9, No. 2 ( 1989-06), p. 123-130
    Details
    In: Cephalalgia, SAGE Publications, Vol. 9, No. 2 ( 1989-06), p. 123-130
    Abstract: After many years of unsuccessful conservative treatment 16 patients suffering from hemicrania are relieved of their pain or are improved by operative treatment. Hemicranial attacks or permanent hemicrania is found to be caused by upper cervical nerve root compression. Vascular compression of C2 ( n = 9) or scar tissue surrounding C2 ( n = 1) or C3 ( n = 1) is the pathology identified in cases of cervicogenic headache or “cluster headache-like” headache. Compression attributable to tumor, prolapsed disc, or spondylotic changes is found to be a cause of permanent headache. Only in those patients with permanent headache are radiological or electrophysiological findings helpful for diagnosis. In patients with hemicranial attacks and compression of nerve root C2 ( n = 10) or C3 ( n = 1), only vasoactive tests (provoking or relieving pain) or local anaesthesia prove to be helpful in diagnosing and localizing the origin of pain. The operation involves freeing the nerve roots from vascular compression. In two patients the C2 ganglion is resected. Thirteen patients subsequently become pain free. In three patients, hemicrania improves. Four of the 16 patients experience a recurrence of pain after the decompressive operation. After additional thermorhizotomy two patients have no further complaints and one patient has improved. One patient can tolerate his pain with occasional analgesics. The problem of referred pain into the fronto-ocular region is discussed.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1046/j.1468-2982.1989.0902123.x
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 2019999-5
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  • 4
    Online Resource
    Online Resource
    Are God’s ‘Good Plans’ not Good Enough? The Place and Significance of Jer 29.15 in Jeremiah’s Letter to the Exiles
    SAGE Publications ; 2021
    In:  Journal for the Study of the Old Testament Vol. 45, No. 4 ( 2021-06), p. 561-575
    Details
    In: Journal for the Study of the Old Testament, SAGE Publications, Vol. 45, No. 4 ( 2021-06), p. 561-575
    Abstract: My analysis of Jer 29 argues for including v. 15 in the unit describing God’s ‘good plans’, which is delimitated almost always as vv. 10-14. A review of translations and commentators reveals v. 15 to be a crux interpretum, which often is ‘solved’ through textual transposition. Discussing the omission of vv. 16-20 in Jer-LXX as well as some standard indicators of delimitation, such as speech formulas, conjunctions, and scribal paragraph markers, I argue for reading v. 15 as the exiles’ direct response to the preceding divine promises. This understanding of the structure of Jer 29 shifts the main message of the prophet’s letter from God’s ‘good plans’ to the addressee’s rejection of these plans. For a post-exilic readership, the letter explains the suspension of divine restoration and elevates the New Covenant promises of Jer 30-31.
    Type of Medium: Online Resource
    ISSN: 0309-0892 , 1476-6728
    URL: Article
    DOI: 10.1177/0309089220963426
    RVK:
    BA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2068281-5
    SSG: 1
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  • 5
    Online Resource
    Online Resource
    An Improved Behavioural Assay Demonstrates That Ultrasound Vocalizations Constitute a Reliable Indicator of Chronic Cancer Pain and Neuropathic Pain
    SAGE Publications ; 2010
    In:  Molecular Pain Vol. 6 ( 2010-01-01), p. 1744-8069-6-18-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 6 ( 2010-01-01), p. 1744-8069-6-18-
    Abstract: On-going pain is one of the most debilitating symptoms associated with a variety of chronic pain disorders. An understanding of mechanisms underlying on-going pain, i.e. stimulus-independent pain has been hampered so far by a lack of behavioural parameters which enable studying it in experimental animals. Ultrasound vocalizations (USVs) have been proposed to correlate with pain evoked by an acute activation of nociceptors. However, literature on the utility of USVs as an indicator of chronic pain is very controversial. A majority of these inconsistencies arise from parameters confounding behavioural experiments, which include novelty, fear and stress due to restrain, amongst others. Results: We have developed an improved assay which overcomes these confounding factors and enables studying USVs in freely moving mice repetitively over several weeks. Using this improved assay, we report here that USVs increase significantly in mice with bone metastases-induced cancer pain or neuropathic pain for several weeks, in comparison to sham-treated mice. Importantly, analgesic drugs which are known to alleviate tumour pain or neuropathic pain in human patients significantly reduce USVs as well as mechanical allodynia in corresponding mouse models. Conclusions: We show that studying USVs and mechanical allodynia in the same cohort of mice enables comparing the temporal progression of on-going pain (i.e. stimulus-independent pain) and stimulus-evoked pain in these clinically highly-relevant forms of chronic pain.
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1186/1744-8069-6-18
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2174252-2
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  • 6
    Online Resource
    Online Resource
    The Servants of Saul: ‘Minor’ Characters and Royal Commentary in 1 Samuel 9–31
    SAGE Publications ; 2015
    In:  Journal for the Study of the Old Testament Vol. 40, No. 2 ( 2015-12), p. 179-200
    Details
    In: Journal for the Study of the Old Testament, SAGE Publications, Vol. 40, No. 2 ( 2015-12), p. 179-200
    Abstract: Since studies of the Saul narratives in 1 Samuel 9–31 tend to focus on the three main protagonists—Samuel, Saul, and David—characters who play only a minor role have not received much attention. To provide one of these ‘minority perspectives’, this article offers a re-reading of the narrative with a focus on Saul's servants. Although these figures are the only ones who are involved in all of the major scenes of the king's career, their role in the narrative has not been examined. Drawing from six servant passages (1 Sam. 9.1–10.16; 16.14–23; 17–18; 21–22; 28; 31), an attempt is made to show that Saul's servants bear heavily on the development of the plot and that they function as an important, indirect means of the characterization of Saul. The narrative role of these allegedly minor figures therefore has important ramifications for recent efforts to rehabilitate the image of Israel's first king.
    Type of Medium: Online Resource
    ISSN: 0309-0892 , 1476-6728
    URL: Article
    DOI: 10.1177/0309089215621237
    RVK:
    BA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2068281-5
    SSG: 1
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  • 7
    Online Resource
    Online Resource
    Book Reviews : Computing Information Directory 1987
    SAGE Publications ; 1987
    In:  Social Science Microcomputer Review Vol. 5, No. 3 ( 1987-10), p. 437-438
    Details
    In: Social Science Microcomputer Review, SAGE Publications, Vol. 5, No. 3 ( 1987-10), p. 437-438
    Abstract: This is a herculean but ultimately flawed directory of computer-related resources, not including software listings. It includes 1700 journal listings, organized by subject, machine, and computer language; 200 computer center newsletters, with listings of the mainframes each university uses; 30 pages of bibliographic resources, computer dictionary lists, and indexing services; 73 pages on software review listings, mainly from journals; 64 pages on hardware reviews; 95 pages on computer-language resources; plus appendixes on Association for Computing Machinery Proceedings, university computer science libraries, the Library of Congress classification schema, and publishers' addresses. This work is a useful resource for one's library, providing a good start toward finding general computer resources, but it is oriented toward computer science, with only some coverage of instructional computing and very little on social science.
    Type of Medium: Online Resource
    ISSN: 0885-0011
    URL: Article
    DOI: 10.1177/089443938700500345
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1987
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  • 8
    Online Resource
    Online Resource
    The Interview as Persuasive Communication
    SAGE Publications ; 1974
    In:  ABCA Bulletin Vol. 37, No. 3 ( 1974-09), p. 18-21
    Details
    In: ABCA Bulletin, SAGE Publications, Vol. 37, No. 3 ( 1974-09), p. 18-21
    Type of Medium: Online Resource
    ISSN: 0001-0383
    URL: Article
    DOI: 10.1177/108056997403700305
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1974
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  • 9
    Online Resource
    Online Resource
    Business Communication Education in the United States
    SAGE Publications ; 1979
    In:  ABCA Bulletin Vol. 42, No. 1 ( 1979-03), p. 1-6
    Details
    In: ABCA Bulletin, SAGE Publications, Vol. 42, No. 1 ( 1979-03), p. 1-6
    Type of Medium: Online Resource
    ISSN: 0001-0383
    URL: Article
    DOI: 10.1177/108056997904200101
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1979
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  • 10
    Online Resource
    Online Resource
    Proposal for a Master of Business Administration in Business Communication
    SAGE Publications ; 1977
    In:  ABCA Bulletin Vol. 40, No. 1 ( 1977-03), p. 3-7
    Details
    In: ABCA Bulletin, SAGE Publications, Vol. 40, No. 1 ( 1977-03), p. 3-7
    Abstract: A statement prepared by the Graduate Studies Committee of the American Business Communication Asso ciation. Leland Brown, Richard C. Hansen, Richard C. Huseman, William J. Lord, Jr., John D. Pettit, Jr., Michael Porte, Norman B. Sigband, Francis W. Weeks, Robert M. Wendlinger, Richard A. Hatch, and Herbert W. Hildebrandt, Chairman.
    Type of Medium: Online Resource
    ISSN: 0001-0383
    URL: Article
    DOI: 10.1177/108056997704000101
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1977
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