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  • 1
    Book
    Book
    Ann Arbor : The University of Michigan Press
    UID:
    (DE-627)1610239202
    Format: xvi, 222 Seiten , map , 24 cm
    ISBN: 0472098098 , 0472068091
    Note: Includes bibliographical references (p. [185]-220) and index
    Language: English
    Subjects: Sociology
    RVK:
    Keywords: China ; Volkskunde ; China ; Selbst
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  • 2
    Book
    Book
    Ann Arbor : The University of Michigan Press
    UID:
    (DE-602)gbv_1610239202
    Format: xvi, 222 Seiten , map , 24 cm
    ISBN: 0472098098 , 0472068091
    Note: Includes bibliographical references (p. [185]-220) and index
    Language: English
    Subjects: Sociology
    RVK:
    Keywords: China ; Volkskunde ; China ; Selbst
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : eScholarship, University of California
    UID:
    (DE-627)1803297794
    Content: The immune system is essential for host defense to pathogen infection, tissue repair, stress response, and other physiological functions. An unbalanced immune system is detrimental to homeostasis and mammalian survival. Immunodeficiency can cause susceptibility to pathogen infection. A hyperactive immune system can cause autoimmunity and chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and atherosclerosis. Deciphering the mechanisms regulating the immune response will illuminate on the pathogenesis of inflammatory diseases and promote the development of new therapies to treat these diseases. Because innate immunity is the first line of host defense and transcription is a critical contributor to the innate immune response, we focused our studies on mechanisms regulating transcriptional activation of the innate immune response. Toll-like receptor (TLR) signaling is a classical model to study pathogen recognition and the activation of innate immunity. TLR transcriptional cascades have been extensively studied using conventional systems approaches. Because conventional systems approaches rely on statistics and large sample sizes to uncover the common regulatory mechanisms, they often miss gene-specific regulatory mechanisms. To reveal gene-specific regulatory mechanisms, we used a stringent systems approach to dissect the TLR transcriptional cascades in chapter 2. To prevent biases towards the majority of weakly induced genes, we separated strongly induced genes from weakly induced genes. Combining high-resolution transcriptional profiles and perturbation studies, we classified TLR4-activated genes by their activation mechanisms. By integrating RNA-seq, ChIP-seq, ATAC-seq, and motif data, we found that several key inflammatory genes are regulated by highly selective mechanisms. TLR4-activated nuclear factor kappa B (NFκB) and interferon regulatory factor 3 (IRF3) selectively regulate a small subset of pro-inflammatory genes by chromatin and combinatorial regulation. We also found serum response factor (SRF) selectively regulates a few early transient primary response genes. In chapter 3, we used a gene-centric method and identified the motif rules governing the combinatorial regulation of serum response factor (SRF) and ternary complex factor (TCF). Ternary complex formation can enhance SRF binding and promote histone mark deposition. The active ternary complex can regulate transcription through either promoter or enhancer. Taken together, we demonstrated a gene-centric, stringent systems approach that can complement the conventional systems approach to unveil gene-specific regulatory mechanisms in ligand-induced transcriptional cascades.
    Note: Dissertation eScholarship, University of California 2017
    Language: English
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  • 4
    UID:
    (DE-627)183350863
    Format: 303 S
    Edition: Mikrofiche-Ausg. Cambridge M.I.T 1995 4 Mikrofiches
    Note: Cambridge, Massachusetts Inst. of Technology, Ph.D.Thesis : 1992
    Language: English
    Keywords: Hochschulschrift
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  • 5
    UID:
    (DE-627)1630628042
    ISSN: 0964-5691
    In: Ocean & coastal management, Oxford [u.a.] : Elsevier, 1992, 102(2014), Part A, Seite 178-190, 0964-5691
    In: volume:102
    In: year:2014
    In: number:Part A
    In: pages:178-190
    Language: English
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  • 6
    Online Resource
    Online Resource
    Berkeley : University of California Press
    UID:
    (DE-602)gbv_646744828
    Format: Online-Ressource (xvi, 245 p) , ill , cm
    Edition: Online-Ausg. 2005 Electronic reproduction; Available via World Wide Web
    ISBN: 0520219945 , 0520219937
    Content: China underwent a dramatic social transformation in the last decade of the twentieth century. This powerful ethnographic study of one community focuses on the logic of everyday practice in post-reform rural China. Enriched with many vivid anecdotes describing life in the village of Zhaojiahe in northwestern China, In One's Own Shadow skillfully analyzes the changes and continuities marking the recent history of this region and highlights the broader implications for the way we understand Chinese modernity
    Note: Includes bibliographical references (p. 217-235) and index , Preliminaries; Contents; List of Illustrations; Preface; Notes on the Text; 1. Exotic Familiarity; 2. Resisting Ideology; 3. Marriage as a Mirror of Change; 4. Meaning and Eating; 5. The Practice of Everyday Life; 6. The Pliable Emotions; 7. Immoral Politics; Notes; Glossary; Bibliography; Index , Electronic reproduction; Available via World Wide Web
    Additional Edition: ISBN 9780520219939
    Additional Edition: Print version In One's Own Shadow : An Ethnographic Account of the Condition of Post-reform Rural China
    Language: English
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  • 7
    UID:
    (DE-605)HT020755953
    Format: 1 online resource (XIII, 326 p.)
    ISBN: 9783110664928
    Series Statement: Quellen und Studien zur Philosophie 139
    Content: Die vorliegende Arbeit bietet eine einheitliche und systematische Interpretation zu Aristoteles' Metaphysik. Die Autorin fasst diese als Substanz- bzw. Prinzipienlehre auf und überwindet somit die islamisch-scholastische Entzweiung von metaphysica generalis und metaphysica specialis. Dabei wird der Chiasmus als wichtige Einteilungsmethode wiederentdeckt und Aristoteles' Proportionalitätsanalogie von Thomas'Attributionsanalogie klar unterschieden
    Content: This work gives a holistic and systematic interpretation of Aristotle's metaphysics as a doctrine of substance or principles, thereby overcoming the Islamic and Scholastic division between metaphysica generalis and metaphysica specialis. It also rediscovers the chiasmus as a key classificatory method and clearly distinguishes Aristotle's analogy of proportionality from Aquinas's analogy of attribution
    Additional Edition: 9783110663495
    Additional Edition: 9783110663273
    Language: German
    URL: Cover
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  • 8
    Book
    Book
    Ann Arbor : The University of Michigan Press
    UID:
    (DE-605)HT020028486
    Format: xvi, 222 Seiten , Karten
    ISBN: 0472098098 , 0472068091
    Note: Includes bibliographical references (p. [185]-220) and index
    Language: English
    Keywords: China ; Volkskunde
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  • 9
    UID:
    (DE-101)1005655561
    Format: Online-Ressource
    Note: München, Univ., Diss., 2010
    Additional Edition: Druckausg. Liu, Xin, 1972- The U.S. Environmental Protection Agency
    Language: English
    Keywords: Hochschulschrift
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  • 10
    Book
    Book
    New York [u.a.] : Berghahn Books
    UID:
    (DE-602)b3kat_BV041092369
    Format: XII, 209 S.
    Edition: 1. pbk. ed.
    ISBN: 9780857456113
    Series Statement: Culture and politics / politics and culture 5
    Note: Literaturverz. S. 200 - 206
    Language: English
    Subjects: Ethnology , Sociology
    RVK:
    RVK:
    RVK:
    Keywords: China ; Kapitalismus ; Globalisierung ; Sozialer Wandel
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