In:
The EMBO Journal, EMBO, Vol. 42, No. 11 ( 2023-06)
Abstract:
image In the adult hippocampus, most neural stem cells are quiescent and only few become activated and generate new neurons. This study demonstrates an important role of the transcriptional activator Yap1 in mediating the transition between quiescence and activation. Yap1 activity is enriched in activated neural stem cells. Loss‐of‐function and gain‐of‐function experiments support that Yap1 promotes neural stem cell activation. Prolonged Yap1 gain‐of‐function represses hippocampal neurogenesis. Prolonged Yap1 activation leads to aberrant neural cell differentiation and partial glioblastoma stem cell‐like signature.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2021110384
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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