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  • Cambridge University Press (CUP)  (365)
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  • Cambridge University Press (CUP)  (365)
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  • 1
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1958
    In:  Canadian Journal of Economics and Political Science Vol. 24, No. 4 ( 1958-11), p. 541-553
    In: Canadian Journal of Economics and Political Science, Cambridge University Press (CUP), Vol. 24, No. 4 ( 1958-11), p. 541-553
    Abstract: The market for books in Canada is of some interest in itself and as an example of the competition between British and United States goods in an important area. But perhaps no apology is required for addressing an article on such a subject to an academic audience, many of whom have an active and substantial personal interest in the matter. The market for books in Canada is in reality several different markets, sometimes sharply differentiated on the side of the consumer, and often on that of the producer as well. There is, first of all, the division between French- and English-language books, bookstores, and publishers. Then there is the large and valuable market in school books, which is, in the main, dominated by provincial authorities and by a group of publishers catering to the very special and often parochial tastes of these bodies. The university market, though not so clearly differentiated, is coloured to some extent by the necessity of winning “adoptions” of a given text by the instructor, and by the importance of the university bookstore. There is again the substantial market organized by the United States book clubs. Even more important is the competing market in reprints and paperbacks. That sub-section of the English-language market on which most interest centres in this paper is that for so-called trade books, that is, books which are sold to the general reading public.
    Type of Medium: Online Resource
    ISSN: 0315-4890 , 1920-7220
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1958
    detail.hit.zdb_id: 2053066-3
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  • 2
    In: Slavic Review, Cambridge University Press (CUP), Vol. 66, No. 3 ( 2007), p. 580-581
    Type of Medium: Online Resource
    ISSN: 0037-6779 , 2325-7784
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2007
    detail.hit.zdb_id: 2029130-9
    detail.hit.zdb_id: 203404-9
    SSG: 7,39
    SSG: 7,41
    SSG: 3,6
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2001
    In:  Infection Control & Hospital Epidemiology Vol. 22, No. 9 ( 2001-09), p. 576-578
    In: Infection Control & Hospital Epidemiology, Cambridge University Press (CUP), Vol. 22, No. 9 ( 2001-09), p. 576-578
    Abstract: A point-prevalence survey performed among residents of eight nursing homes in Melbourne, Australia, found a rate of fecal VRE colonization of 3.1% (9/292; 95% confidence interval, 1.1-5.1), all van B Enterococcusfaecium. This is a higher rate than in the general community (3.1% vs 0.2%). Many residents (16%) had been inpatients in acute-care hospitals in the previous 3 months.
    Type of Medium: Online Resource
    ISSN: 0899-823X , 1559-6834
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2001
    detail.hit.zdb_id: 2106319-9
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  • 4
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2003
    In:  Infection Control & Hospital Epidemiology Vol. 24, No. 5 ( 2003-05), p. 322-326
    In: Infection Control & Hospital Epidemiology, Cambridge University Press (CUP), Vol. 24, No. 5 ( 2003-05), p. 322-326
    Abstract: To determine the prevalence of MRSA colonization on admission to the ICU and the incidence of MRSA colonization in the ICU. Design: Prospective cohort study. Setting: University hospital. Participants: Patients admitted to the ICU in 2000-2001. Methods: Patients were screened for MRSA with nose, throat, groin, and axilla swabs on admission and discharge. MRSA acquisition was defined as a negative admission screen and a positive discharge screen. Risk factors analyzed included previous wards/current unit, gender, age, and length of stay prior to and in the ICU. Univariate and multivariate analyses were performed using logistic regression. Results: Of screened patients, 6.8% were MRSA colonized on admission to the ICU. Some patients (11.4%) became newly colonized during their stay in the ICU. Factors that remained significant in the multivariate analysis of MRSA colonization on admission were previous admission to various wards and length of stay prior to ICU admission of more than 3 days. In the multivariate analysis of MRSA acquisition in the ICU, being a trauma patient and length of stay in the ICU greater than 2 days remained significant. Thirty-six percent of patients had both admission and discharge swabs taken. This percentage increased in the presence of a supervisory nurse. Conclusion: Significant acquisition of MRSA occurs in the ICU of our hospital, with trauma patients at increased risk. Patients who had been on the cardiothoracic ward prior to the ICU had a lower risk of MRSA colonization on admission. Presence of a supervisory nurse improved compliance with screening.
    Type of Medium: Online Resource
    ISSN: 0899-823X , 1559-6834
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2106319-9
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  • 5
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1955
    In:  Canadian Journal of Economics and Political Science Vol. 21, No. 1 ( 1955-02), p. 64-72
    In: Canadian Journal of Economics and Political Science, Cambridge University Press (CUP), Vol. 21, No. 1 ( 1955-02), p. 64-72
    Abstract: The essence of federalism is the division of sovereignty between two levels of government. In any system of government, there are sovereign and delegated authorities. In a unitary government all sovereign powers are concentrated in the central government, although decentralization for the purpose of administrative efficiency may result in the delegation of certain powers from the central and supreme government to the regional and local subordinate authorities. In a federal state, on the other hand, regional governments, as well as the central authority, are invested with sovereign powers. In no actual case, however, do both levels of government enjoy sovereignty in all domains, since complete concurrence of jurisdictions would lead to incessant conflicts of coordinate authorities. For this reason, federal constitutions indicate, in a more or less precise way, the special fields of absolute competence of the central and the regional authorities. Partial concurrence of jurisdictions may not be excluded, in which case the problem of bringing about agreements between the sovereign powers arises. Administrative efficiency in a federal state requires both centralization and decentralization of executive functions, in much the same way as in a unitary state. If subordinate functions are delegated to the regional governments, these governments become subordinate to the central authority in these fields. On the other hand, administrative efficiency may require the centralized administration of certain matters in the realm of provincial supremacy, for example, the collection of provincial taxes. In this case, the central government would act as an agent of the provincial governments, and be subordinate to them. The two types of powers–sovereign and delegated–must be clearly distinguished in order to prevent unnecessary conflicts of authority.
    Type of Medium: Online Resource
    ISSN: 0315-4890 , 1920-7220
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1955
    detail.hit.zdb_id: 2053066-3
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  • 6
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1964
    In:  Journal of Inter-American Studies Vol. 6, No. 4 ( 1964-10), p. 463-487
    In: Journal of Inter-American Studies, Cambridge University Press (CUP), Vol. 6, No. 4 ( 1964-10), p. 463-487
    Abstract: This study of financial institutions and processes highlights changes in the policies and practices of investors, governments and international bodies that would accelerate industrial development of Central America. There are three principal conclusions: 1. Commercial banks and related institutions need more flexibility in their operations under the law and administrative procedures. Among these conditions would be adaptations of credit instruments and interest rates to the requirements of a changing economic structure and market conditions. These would increase the number and range of alternatives open to domestic savers and investors and enable financial institutions to undertake operations of longer terms and greater risks.
    Type of Medium: Online Resource
    ISSN: 0885-3118 , 2326-4047
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1964
    detail.hit.zdb_id: 2052224-1
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  • 7
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2023
    In:  Journal of Clinical and Translational Science Vol. 7, No. s1 ( 2023-04), p. 59-59
    In: Journal of Clinical and Translational Science, Cambridge University Press (CUP), Vol. 7, No. s1 ( 2023-04), p. 59-59
    Abstract: OBJECTIVES/GOALS: Partner with the entertainment industry to build trust in science and research, especially among high-disparity and underserved communities, through inclusion of research themes on popular television shows. METHODS/STUDY POPULATION: To date, our partnerships with TV writers have led to inclusion of clinical research storylines on 10 popular TV shows (e.g., Grey’s Anatomy with an audience of 7M). We are now conducting research on show popularity among diverse audiences, and interviewing medical and entertainment experts to understand health priorities and potential entry-points to deliver targeted outreach. We are also analyzing keywords in scripts to assess frequency and sentiment of medical topics in entertainment. Our team also consults with the TV community regarding storylines and public service announcements on health and innovations in medicine. RESULTS/ANTICIPATED RESULTS: We anticipate reporting insights into current and shifting narratives around future-of-medicine topics. Building on work that reached over 64M viewers, more frequent and accurate depictions will likely be related to positive changes in attitudes, behaviors, and trust regarding health and science. The overall goal is to foster attitudes among high-disparity and underserved populations that will increase service utilization and early screenings, foster trust in research and evolving medical technologies, and combat misinformation. DISCUSSION/SIGNIFICANCE: By working with television writers of shows proven to be popular among key audiences, this initiative has the potential to reach millions of viewers in their homes with important and timely information modeling healthy behavior, providing accurate facts, depicting cutting edge research, and emphasizing diversity in medical research.
    Type of Medium: Online Resource
    ISSN: 2059-8661
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2898186-8
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  • 8
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1987
    In:  International Journal of Legal Information Vol. 15, No. 5-6 ( 1987-12), p. 292-294
    In: International Journal of Legal Information, Cambridge University Press (CUP), Vol. 15, No. 5-6 ( 1987-12), p. 292-294
    Type of Medium: Online Resource
    ISSN: 0731-1265 , 2331-4117
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1987
    detail.hit.zdb_id: 2409551-5
    detail.hit.zdb_id: 720880-7
    SSG: 24,1
    SSG: 2
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  • 9
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2022
    In:  Journal of Clinical and Translational Science Vol. 6, No. s1 ( 2022-04), p. 31-31
    In: Journal of Clinical and Translational Science, Cambridge University Press (CUP), Vol. 6, No. s1 ( 2022-04), p. 31-31
    Abstract: OBJECTIVES/GOALS: Pancreatic ductal adenocarcinoma (PDAC) is a relatively radioresistant disease, and inhibition of DNA homologous recombination (HR) repair in combination with radiation therapy (RT) is a potentially attractive strategy to overcome radioresistance. We have found that the expression of the HR protein RAD18 is upregulated in PDAC cells. METHODS/STUDY POPULATION: Standard clonogenic assays, γH2aX foci staining, HR-GFP reporter assay, and western blot analysis of DNA damage response proteins were performed in MIA-PaCa2 (MP2) and PANC-1 cells following knockdown of RAD18 in cells via short hairpin RNA (shRNA). Drug targeting of RAD18 was achieved through the use of a USP-7 inhibitor, P5091. Cells with or without stable knockdown of RAD18 were implanted orthotopically in the pancreas of athymic nude mice and treated with sham radiation or radiation to a dose of 20 Gy in 5 daily fractions once tumors reached 100-150 mm3. RESULTS/ANTICIPATED RESULTS: Stable knockdown of RAD18 in MP2 and PANC-1 resulted in decreased radiation clonogenic survival in vitro (dose enhancement factor (DEF)=1.52 and 1.51, respectively), decreased DNA repair after radiation as measured by the increased number of γH2aX nuclear foci assay at 6, 12, and 24 hours (all p 〈 0.05), decreased HR activation following DNA damage via an HR-GFP reporter assay (p=0.039), and increased tumor growth delay following radiation in vivo (p 〈 0.001). P5091 treatment of both MP2 and PANC-1 resulted in efficient knockdown of RAD18, which was confirmed through western blotting, qRT-PCR, and luciferase reporter assays. P5091 increased radiosensitization, yH2aX nuclear foci remained elevated at 12 and 24 hours (p 〈 0.05), and HR repair was also reduced (p=0.014). DISCUSSION/SIGNIFICANCE: Herein, we show the HR repair protein RAD18, and that modulation of RAD18 expression correlates with in vitro and in vivo radiosensitization through altered HR-mediated DNA repair. USP7 inhibition successfully reduced RAD18 expression and resulted in enhanced radiosensitization.
    Type of Medium: Online Resource
    ISSN: 2059-8661
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2898186-8
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  • 10
    In: Albion, Cambridge University Press (CUP), Vol. 30, No. 2 ( 1998), p. 384-385
    Type of Medium: Online Resource
    ISSN: 0095-1390 , 2326-1242
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1998
    detail.hit.zdb_id: 2394489-4
    SSG: 7,25
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