In:
Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 361-363 ( 2007-11), p. 519-522
Abstract:
Poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric was made by
electro-spinning method for the potential application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the
presence of calcium salt, water, hydrochloric acid and ethanol. Poly(lactic-co-glycolic)acid solution was prepared by dissolving it in the hexafluoroisopropanol. Then, they were transferred to two
separate syringes which were connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica gel containing calcium and
poly(lactic-co-glycolic)acid solution were spun together under the electric field of 2 ㎸/㎝. The FE-SEM observations showed that the silica gel and poly(lactic-co-glycolic)acid fibers were mixed
together completely and its handling property was much improved compared to that of the non-woven silica gel fabric. After soaking in the SBF for 1 week, low crystalline apatite crystals were also
observed to occur on the silica fiber surfaces first and then they were also observed to occur on the poly(lactic-co-glycolic)acid fiber surfaces. From the results, it can be concluded that the
poly(lactic-co-glycolic)acid and silica gel fibers mixed non-woven fabric made by electro-spinning method has a bioactivity. It means it has a potential to be used as a bone grafting material because of
its apatite-forming ability, high surface area to volume ratio and high porosity.
Type of Medium:
Online Resource
ISSN:
1662-9795
DOI:
10.4028/www.scientific.net/KEM.361-363
DOI:
10.4028/www.scientific.net/KEM.361-363.519
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2007
detail.hit.zdb_id:
2073306-9
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