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  • 1
    Online Resource
    Online Resource
    Uric acid levels in chronic kidney disease- a hospital based cross-sectional study in RIMS, Ranchi, Jharkhand
    Medip Academy ; 2021
    In:  International Journal of Research in Medical Sciences Vol. 9, No. 2 ( 2021-01-29), p. 569-
    Details
    In: International Journal of Research in Medical Sciences, Medip Academy, Vol. 9, No. 2 ( 2021-01-29), p. 569-
    Abstract: Background: Uric acid is the final end product of purine metabolism and is excreted mainly by proximal tubules of the kidney. Raised uric acid levels may lead to proximal tubular injury, endothelial dysfunction, oxidative stress and intra renal inflammation in patients with normal renal function. Uric acid has been deemed as an independent risk factor for progression of CKD. Aim was to study the uric acid levels in different stages of chronic kidney disease and its association with age, sex and other co-morbidities.Methods: 140 patients of chronic kidney disease admitted in RIMS, Ranchi were included in this study and their serum uric acid level were analyzed. Uric acid level more than 7 mg/dl was considered as hyperuricemia. The study was approved by the Institutional Ethics Committee, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India. Informed consent was taken from every patient included in the study.Results: Median age±SD was 55±13.47 years (IQR: 45,65; Range: 19-80). Mean±SD uric acid levels in stage 3 CKD was 4.4±1.9 mg/dl, stage 4 CKD was 6.5±4.1 mg/dl, stage 5 CKD was 8.8±3.1 mg/dl (p 〈 0.05). Females were 31.4% and males were 69.6%. Male to female ratio was 2.2:1. The prevalence of hyperuricemia was 50% in females and 66.6% in males.Conclusions: Hyperuricemia is common among CKD patients and more common among males. Uric acid levels increase with progressive decline in eGFR. Monitoring and follow-up of such patients by may lead to delay in onset and progression of complications of CKD.
    Type of Medium: Online Resource
    ISSN: 2320-6012 , 2320-6071
    URL: Article
    DOI: 10.18203/2320-6012.ijrms20210444
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    EFFECT OF TINOSPORA CORDIFOLIA IN CHRONIC BRONCHITIS PATIENTS
    Akshantala Enterprises Private Limited ; 2017
    In:  Journal of Evolution of Medical and Dental Sciences Vol. 6, No. 23 ( 2017-03-20), p. 1850-1857
    Details
    In: Journal of Evolution of Medical and Dental Sciences, Akshantala Enterprises Private Limited, Vol. 6, No. 23 ( 2017-03-20), p. 1850-1857
    Type of Medium: Online Resource
    ISSN: 2278-4748 , 2278-4802
    Uniform Title: English
    URL: Journal
    URL: Article
    DOI: 10.14260/jemds
    DOI: 10.14260/Jemds/2017/408
    Language: Unknown
    Publisher: Akshantala Enterprises Private Limited
    Publication Date: 2017
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  • 3
    Online Resource
    Online Resource
    Utilization of vitamin A supplementation services in high priority districts of Bihar
    Medip Academy ; 2018
    In:  International Journal Of Community Medicine And Public Health Vol. 5, No. 2 ( 2018-01-24), p. 667-
    Details
    In: International Journal Of Community Medicine And Public Health, Medip Academy, Vol. 5, No. 2 ( 2018-01-24), p. 667-
    Abstract: Background: Vitamin A deficiency (VAD) is a major preventable public health problem. Prevalence of VAD in preschool children was 5.7% (India), and 4.5% (Bihar). India is implementing biannual Vitamin A Supplementation (VAS) since 2007 along with 80 other countries. VAS was originally proposed as a short term measure, followed by dietary improvement. Since vulnerability to VAD is more in high priority districts (HPDs), it was deemed worthwhile to study the extent to which VAS programme is utilized in the 10 HPDs of Bihar with respect to the processes involved and the ultimate outcome of empowering the community with knowledge and capacity to combat VAD on their own.Methods: Cross sectional observational study conducted in 6 randomly selected blocks and 5 session sites per block of the 10 HPDs. 300 sites sampled for processes and 893 caregivers interviewed for their knowledge.Results: Out of 300 sites, 269 sites found functional, 30.85% sites had due lists and 30.11% had MCP cards; 20.44% had adequate VA. IEC displayed at 52.78% and 71.3% sessions conducted in shade. In 79.55% sites efforts made to determine age of child before administration. Correct use of recommended spoon known to 80.66%, benefits of VA to 76.57% and diseases due to VAD to 81.7% of FLWs. Knowledge regarding VA good in 33.4% of caregivers, average in 35.5%, and poor in 30.9%.Conclusions: Crucial gaps found in necessary inputs and conduct of VAS. Community knowledge found lacking for sustainable programme withdrawal. Better programme management will improve utilization. 
    Type of Medium: Online Resource
    ISSN: 2394-6040 , 2394-6032
    URL: Article
    DOI: 10.18203/2394-6040.ijcmph20180248
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2018
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  • 4
    Online Resource
    Online Resource
    CORRECTION OF ANAEMIA WITH ERYTHROPOIETIN IN CKD/ESRD PATIENTS
    Akshantala Enterprises Private Limited ; 2015
    In:  Journal of Evolution of Medical and Dental Sciences Vol. 04, No. 12 ( 2015-02-06), p. 1927-1935
    Details
    In: Journal of Evolution of Medical and Dental Sciences, Akshantala Enterprises Private Limited, Vol. 04, No. 12 ( 2015-02-06), p. 1927-1935
    Type of Medium: Online Resource
    ISSN: 2278-4748 , 2278-4802
    Uniform Title: English
    URL: Journal
    URL: Article
    DOI: 10.14260/jemds
    DOI: 10.14260/jemds/2015/280
    Language: Unknown
    Publisher: Akshantala Enterprises Private Limited
    Publication Date: 2015
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  • 5
    Online Resource
    Online Resource
    Immunosuppressive drugs in renal transplantation
    Medip Academy ; 2023
    In:  International Journal of Basic & Clinical Pharmacology Vol. 12, No. 2 ( 2023-02-22), p. 303-312
    Details
    In: International Journal of Basic & Clinical Pharmacology, Medip Academy, Vol. 12, No. 2 ( 2023-02-22), p. 303-312
    Abstract: A kidney transplant, sometimes known as a renal transplant, is the treatment of choice for kidney failure at end stage renal disease (ESRD). The renal transplant surgery is followed by a lifetime course of immunosuppressive agents, divided into initial induction phase and later maintenance phase. It is seen that the risk of acute rejection is maximum in the initial months after transplantation (induction phase) and then reduces later (maintenance phase). In induction phase there is use of high-intensity immunosuppression immediately after transplantation, when the risk of rejection is maximum and then the dose reduced for long- term therapy. The main challenge in the renal transplantation community is long- term transplant survival. Long-term graft loss is mainly due to acute and chronic graft rejection, and also due to complications of immunosuppressive therapy. Currently, there is triple therapy as conventional immunosuppressive protocol: a calcineurin inhibitor, an antimetabolite agent, and a corticosteroid. The main aim of development of new immunosuppressive agents is not only improvement of short- term outcomes but also to increase the long- term graft survival by less nephrotoxicity, and minimal side-effects.
    Type of Medium: Online Resource
    ISSN: 2279-0780 , 2319-2003
    URL: Article
    DOI: 10.18203/2319-2003.ijbcp20230405
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2023
    detail.hit.zdb_id: 2681376-2
    SSG: 15,3
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
  • 6
    Online Resource
    Online Resource
    A case of drug induced dizziness in a patient on anti-Parkinson drugs
    Medip Academy ; 2023
    In:  International Journal of Basic & Clinical Pharmacology Vol. 12, No. 2 ( 2023-02-22), p. 268-271
    Details
    In: International Journal of Basic & Clinical Pharmacology, Medip Academy, Vol. 12, No. 2 ( 2023-02-22), p. 268-271
    Abstract: Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease, exceeded only by Alzheimer’s disease. Clinically, PD is characterized by resting tremor, rigidity (stiffness), bradykinesia (slowing), and gait dysfunction with postural instability. These are known as the classical or “cardinal” features of the disease. Levodopa remains the most effective symptomatic treatment for PD and the gold standard against which new therapies are compared. Levodopa is routinely administered in combination with a peripheral decarboxylase inhibitor to prevent its peripheral metabolism to dopamine and the development of nausea, vomiting, and orthostatic hypotension. The major concern with levodopa is that chronic levodopa treatment is associated with the development of motor complications, nausea and dizziness in the large majority of patients. We are here reporting a case of Syndopa plus (Levodopa+Carbidopa) induced dizziness in a 76 years old male patient on anti- parkinsonism treatment. The causality assessment was done by Naranjo scale. The causality of Syndopa plus in the case was “probable” as per Naranjo scale. The patient was managed by reducing the dose of Syndopa plus to the half of it’s initial dose. The case was recorded properly in adverse drug reaction reporting form and was sent to nearby ADR (adverse drug reaction) monitoring centre.
    Type of Medium: Online Resource
    ISSN: 2279-0780 , 2319-2003
    URL: Article
    DOI: 10.18203/2319-2003.ijbcp20230400
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2023
    detail.hit.zdb_id: 2681376-2
    SSG: 15,3
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
  • 7
    Online Resource
    Online Resource
    Extensive early mineralization of pre-osteoblasts, inhibition of osteoclastogenesis and faster peri-implant bone healing in osteoporotic rat model: principle effectiveness of bone-specific delivery of Tibolone as evaluated in vitro and in vivo
    IOP Publishing ; 2020
    In:  Biomedical Materials Vol. 15, No. 6 ( 2020-11-01), p. 064102-
    Details
    In: Biomedical Materials, IOP Publishing, Vol. 15, No. 6 ( 2020-11-01), p. 064102-
    Abstract: Hydrophobic drug molecules pose a significant challenge in immobilization on super-hydrophobic metallic surfaces like conventional titanium implants. Pre-coating surface modifications may yield a better platform with improved wettability for such purposes. Such modifications, as depicted in this study, were hypothesized to provide the requisite roughness to assist deposition of polymers like silk fibroin (SF) as a drug-binding matrix in addition to significant improvement in early protein adsorption, which facilitates faster cellular adhesion and proliferation. A silk-based localized drug delivery module was developed on the titanium surface and tested for its surface roughness, wettability, biocompatibility and in vitro differentiation potential of cells cultured on the coated metallic surfaces with/without external supplementation of the active metabolite of Tibolone. Conditioning of the matrix-coated implants with osteogenic as well as osteoclastogenic media supplemented with Tibolone stimulated the expression of early osteogenic gene and calcium deposition in the extracellular matrix. Significant inhibition in resorptive activity was also observed in the presence of the drug. To assess the efficacy of localized delivery of Tibolone via topographically modified titanium implants for inducing early peri-implant bone formation, osteoporosis was artificially induced in rats subjected to bilateral ovariectomy and implants were placed thereafter. Bone-specific release of Tibolone through the biomimetic matrix in osteoporotic rats collectively indicated significant improvement in peri-implant bone growth after 2 and 4 weeks ( p 〈 0.05 compared to dummy-coated implants). These findings demonstrate for the first time that Tibolone released from SF matrix-coated implants can accelerate the biological stability of bone fixtures.
    Type of Medium: Online Resource
    ISSN: 1748-6041 , 1748-605X
    URL: Article
    DOI: 10.1088/1748-605X/abb12b
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2233169-4
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    BTU Cottbus
  • 8
    Online Resource
    Online Resource
    Accelerating Genetic Algorithm Using General Purpose GPU and CUDA
    Global Vision Press ; 2016
    In:  International Journal of Computer-aided Mechanical Design and Implementation Vol. 2, No. 1 ( 2016-03-30), p. 9-22
    Details
    In: International Journal of Computer-aided Mechanical Design and Implementation, Global Vision Press, Vol. 2, No. 1 ( 2016-03-30), p. 9-22
    Type of Medium: Online Resource
    ISSN: 2205-8591
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.21742/ijcmdi.2016.2.1
    DOI: 10.21742/ijcmdi
    DOI: 10.21742/ijcmdi.2016.2.1.02
    Language: Unknown
    Publisher: Global Vision Press
    Publication Date: 2016
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  • 9
    Online Resource
    Online Resource
    A Study of Thyroid Profile (FT3, FT4, TSH) in Liver Cirrhosis in Jharkhand - A Hospital based Study
    Radiance Research Academy ; 2022
    In:  International Journal of Current Research and Review Vol. 14, No. 06 ( 2022), p. 95-100
    Details
    In: International Journal of Current Research and Review, Radiance Research Academy, Vol. 14, No. 06 ( 2022), p. 95-100
    Abstract: in people with liver disorders. Aim: To determine the prevalence of thyroid dysfunction in liver cirrhosis patients. Materials and Methods: This case-control study was carried out in a group of randomly selected liver cirrhosis patients in the Department of Medicine at Rajendra Institute of Medical Sciences (R.I.M.S), Ranchi, Jharkhand (India) between September 2017 to August 2018. The equal number of age ( 〉 18 years) and sex-matched cases & controls were included in this study. Radioimmunoassays were used to evaluate early morning fasting blood thyroid-stimulating hormone (TSH), serum total free thyroxine (FT4), and free triiodothyronine (FT3) in 100 index patients with liver cirrhosis who had no history of thyroid disorders. Results: In the cases that were studied, which consisted of cirrhotic patients, males (80%) outnumbered females (20%). The mean age of cases was 47.9 years, and the maximum numbers of the patient were between 41-55 years of age group (47%). Among the cirrhotic patients, the commonest etiology was alcoholic liver disease which contributed to 78% of the total cases studied. The rest of the cases included cirrhotics from other etiologies, which included NAFLD (22%), HBsAg positive individuals (07%), and other cases of cryptogenic origin. The mean FT3, FT4, and TSH values in cases were 2.29±0.83; 1.20±0.55 & 3.76±2.43 respectively & the mean FT3, FT4, and TSH of the control group were 2.95±0.52; 1.40±0.25 & 2.70±0.94 respectively. From these data, we can say that there is significant derangement of thyroid function in liver cirrhosis in favor of hypothyroidism (p 〈 0.05). Conclusion: Hypothyroidism, or abnormalities in circulating thyroid hormone concentrations, is seen in people with alcoholrelated liver cirrhosis and is linked to more severe liver disease
    Type of Medium: Online Resource
    ISSN: 2231-2196 , 0975-5241
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.31782/IJCRR.2022
    DOI: 10.31782/IJCRR
    DOI: 10.31782/IJCRR.2022.14615
    Language: Unknown
    Publisher: Radiance Research Academy
    Publication Date: 2022
    detail.hit.zdb_id: 2620630-4
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
  • 10
    Online Resource
    Online Resource
    Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009
    Journal of Infection in Developing Countries ; 2010
    In:  The Journal of Infection in Developing Countries Vol. 4, No. 06 ( 2010-05-11), p. 404-411
    Details
    In: The Journal of Infection in Developing Countries, Journal of Infection in Developing Countries, Vol. 4, No. 06 ( 2010-05-11), p. 404-411
    Abstract: Enteric fever is responsible for significant morbidity in South Asia and high prevalence of severe disease is seen in children under two years of age. Effective typhoid vaccines are available, but they cannot be used for children under two years of age and also have some limitations in older age groups. Participants supported development of a Salmonella Typhi conjugate vaccine able to induce effective, long-lasting immunity in young children. The role of Salmonella Paratyphi A as a cause of enteric fever was discussed and consensus reached that a bivalent S. Typhi-S. Paratyphi A conjugate vaccine is highly desirable; however, considering disease epidemiology and the advanced status of vaccine development, rapid introduction of monovalent S. Typhi conjugate vaccine into vaccination programs of South Asia was recommended. Prevention should be emphasized, available vaccines used, and efforts toward improving sanitation continued. Success of the new vaccine will depend on several factors, including delivery costs and governmental ability to adopt and implement suitable immunization programs. To ensure good immunization coverage, the conjugate vaccine could be administered either to young infants, concomitantly with infant EPI vaccines, or to older infants, concomitantly with measles vaccine, currently given at 9 to 12 months. The need for new combination vaccines, containing both EPI and typhoid antigens, was discussed as a tool to increase coverage and reduce the number of injections and priority conflicts in a crowded infant vaccination schedule. However, stand-alone enteric fever conjugate vaccines would allow more flexibility to immunize different age groups and therefore should be rapidly developed.
    Type of Medium: Online Resource
    ISSN: 1972-2680
    URL: Article
    DOI: 10.3855/jidc.1048
    Language: Unknown
    Publisher: Journal of Infection in Developing Countries
    Publication Date: 2010
    detail.hit.zdb_id: 2394024-4
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    BTU Cottbus
    Wissenschaftspark Albert Einstein
    EUV Frankfurt
    TH Wildau
    FH Potsdam
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