In:
International Journal of Cancer, Wiley, Vol. 135, No. 9 ( 2014-11), p. 2096-2106
Abstract:
What's New? While chemokines are known to play key roles in both driving and preventing cancer progression, their expression and biological significance in soft tissue sarcoma (STS) remain unclear. This study shows that monocyte chemotactic protein‐1 (MCP1/CCL2) and fractalkine (CX3CL1) affect the prognosis of STS patients. The high mRNA expression of both chemokines is correlated with a good outcome in STS patients, particularly in female STS patients. The study provides evidence supporting the hypothesis that CCL2 and CX3CL1 have a promoting effect on apoptosis induction in STS. A possible explanation for the gender difference is the gender‐specific regulation of chemokines by hormones/receptors.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Bookmarklink