In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 84, No. S1 ( 1988-11-01), p. S54-S54
Abstract:
Hair cells located in the cochlear apex were destroyed by low-frequency noise exposure or by application of a − 140 °C cryoprobe to the bony wall of the apical turn. Complementary lesions that spared apical hair cells were produced by treatment with ototoxic antibiotics. Behavioral thresholds were measured in monkeys, chinchillas, and guinea pigs before and after these treatments. The results showed (1) with loss of up to 80% of apical outer hair cells, thresholds were unchanged; (2) with complete loss of both outer and inner apical hair cells, thresholds shifted approximately 20 dB at low frequencies; and (3) with complete loss of hair cells except in the apex, some hearing remained, with better hearing at low frequencies. Addition of a high-pass masker always elevated high-frequency thresholds, but only elevated low-frequency thresholds when all apical hair cells had been destroyed, indicating that basal hair cells can respond to low-frequency stimuli. Compared to data from more basal portions of the cochlea, these data suggest that functional differences exist between the base and apex, with comparable damage in the apex resulting in less hearing impairment. [Work supported by NINCDS grants NS05785 and NS25564.]
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
1988
detail.hit.zdb_id:
1461063-2
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