Format:
1 online resource (257 pages)
ISBN:
9780123849229
Series Statement:
Issn Ser. v.Volume 67
Content:
This volume of Current Topics in Membranes focuses on adrenergic receptor biology, beginning with a review of past successes and historical perspectives then further discussing current general trends in adrenic receptor studies in various contexts. This publication also includes discussions of the role and relationship of adrenergic receptors to different systems and diseases, establishing adrenergic receptor biology as a needed, practical reference for researchers.
Content:
Cover -- Advances in Adrenergic Receptor Biology -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Previous Volumes in Series -- Chapter 1 - Historical Perspective for Understanding of Adrenergic Receptors -- Overview -- Introduction: it's all About Specificity -- Adrenergic Receptor Identification -- What Makes an Agonist Different from an Antagonist? -- Rhodopsin Enlightens Adrenergic Receptor Structure - Function Studies -- Arrestins -- Their "First-Generation" Role as Mediators of Homologous Desensitization Evoked by Adrenergic Receptors -- Arrestins as Adapters for Endocytosis Via Clathrin-Coated Pits -- Arrestin Scaffolding of Non-G Protein-Dependent Signaling Makes Possible Ligand-Biased Signaling Along G Protein-Dependent and -Independent Signaling Networks -- Molecular Cloning Permits Structure - Function Analysis of Adrenergic Receptors via Multiple Experimental Strategies -- -- At Last, a Structure for The β2- Adrenergic Receptor -- Gene Targeting Studies Reveal Subtype Selective Roles for Adrenergic Receptors in In Vivo Settings -- -- Newer Generation Genetic Manipulations Provide Insights into The Pre-versus Postsynaptic Roles of α2-adrenergic Receptors -- The Multiple Interacting Proteins of Adrenergic Receptors -- And That Brings us Back to the Issue of Specificity and Therapeutic Selectivity -- Acknowledgments -- References -- Chapter 2 - Organizational Complexity of β-adrenergic Receptor Signaling Systems -- Overview -- Introduction -- General Considerations Regarding GPCR Organization -- Signaling Diversity in β-Adrenergic Receptors -- The Impact of Recent Crystal Structures on Our Understanding of Biased Signaling -- Larger Receptor Arrays -- βAR Homodimers -- βAR Heterodimerization -- βAR Interactions with Other Receptor Classes -- Interactions with G Proteins and Effector Molecules.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9780123849212
Additional Edition:
Erscheint auch als Druck-Ausgabe 9780123849212
Language:
English
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