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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing, | Cham :Springer.
    UID:
    edoccha_BV048918788
    Format: 1 Online-Ressource (VIII, 353 p. 1 illus).
    Edition: 1st ed. 2023
    ISBN: 978-3-031-23965-6
    Series Statement: Cardiac and Vascular Biology 9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23964-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23966-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23967-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing, | Cham :Springer.
    UID:
    edocfu_BV048918788
    Format: 1 Online-Ressource (VIII, 353 p. 1 illus).
    Edition: 1st ed. 2023
    ISBN: 978-3-031-23965-6
    Series Statement: Cardiac and Vascular Biology 9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23964-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23966-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23967-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Springer
    UID:
    b3kat_BV048918788
    Format: 1 Online-Ressource (VIII, 353 p. 1 illus)
    Edition: 1st ed. 2023
    ISBN: 9783031239656
    Series Statement: Cardiac and Vascular Biology 9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23964-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23966-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23967-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 4
    UID:
    b3kat_BV047932439
    Format: 1 Online-Ressource (89 Seiten)
    Series Statement: OECD Series on Adverse Outcome Pathways
    Content: This AOP details the linkage between activation of the aryl hydrocarbon receptor (AhR) and early life stage mortality in oviparous vertebrates. It can be initiated mostly by dioxin-like compounds, which are able to bind to the AhR causing heterodimerisation with the aryl hydrocarbon nuclear translocator (ARNT) and interaction with dioxin-responsive elements on the DNA causing an up-regulation in dioxin responsive genes. One dioxin-responsive gene is cyclooxygenase 2 (COX-2), which has roles in development of the cardiovascular system. Up-regulation in expression of COX-2 causes alteration in cardiovascular development and function resulting in reduced heart pumping efficiency, reduced blood flow, and eventual cardiac collapse and death. Comparable apical manifestations of activation of the AhR have been recorded across freshwater and marine teleost and non-teleost fishes, as well as birds. Despite conservation in the AOP across taxa, great differences in sensitivity to perturbation exist both among and within taxonomic groups
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 5
    UID:
    gbv_1747663204
    Format: 1 Online-Ressource (89 p.)
    Series Statement: OECD Series on Adverse Outcome Pathways no.12
    Content: This AOP details the linkage between activation of the aryl hydrocarbon receptor (AhR) and early life stage mortality in oviparous vertebrates. It can be initiated mostly by dioxin-like compounds, which are able to bind to the AhR causing heterodimerisation with the aryl hydrocarbon nuclear translocator (ARNT) and interaction with dioxin-responsive elements on the DNA causing an up-regulation in dioxin responsive genes. One dioxin-responsive gene is cyclooxygenase 2 (COX-2), which has roles in development of the cardiovascular system. Up-regulation in expression of COX-2 causes alteration in cardiovascular development and function resulting in reduced heart pumping efficiency, reduced blood flow, and eventual cardiac collapse and death. Comparable apical manifestations of activation of the AhR have been recorded across freshwater and marine teleost and non-teleost fishes, as well as birds. Despite conservation in the AOP across taxa, great differences in sensitivity to perturbation exist both among and within taxonomic groups.
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham : Springer
    UID:
    b3kat_BV047226753
    Format: 1 Online-Ressource (xi, 352 Seiten) , Illustrationen
    ISBN: 9783030631642
    Series Statement: Cardiac and vascular biology volume 8
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-030-63163-5
    Additional Edition: Erscheint auch als Druck-Ausgabe, Paperback ISBN 978-3-030-63166-6
    Language: English
    Keywords: Aufsatzsammlung
    URL: Volltext  (URL des Erstveröffentlichers)
    Author information: Hecker, Markus 1960-
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore, | Singapore :Springer.
    UID:
    edocfu_BV049725891
    Format: 1 Online-Ressource (VII, 212 p. 49 illus., 46 illus. in color).
    Edition: 1st ed. 2024
    ISBN: 978-981-9713-63-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-9713-62-2
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-9713-64-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-981-9713-65-3
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 8
    UID:
    almahu_9949482373002882
    Format: VIII, 353 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031239656
    Series Statement: Cardiac and Vascular Biology, 9
    Content: This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.
    Note: Foreword -- Cardiac mechanoperception and mechanotransduction - Mechanisms of stretch sensing in cardiomyocytes and implications for cardiomyopathy -- Mechanotransduction in heart development -- Mechanobiology of cardiac growth in health and disease -- The role of mechanosensitive signaling cascades in repair and fibrotic remodeling of the infarcted heart -- Mechanobiology of cardiac fibroblasts in cardiac remodelling -- Mechanobiology of cardiac remodelling in cardiomyopathy -- Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-derived Cardiomyocytes -- Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration -- Mechanobiology of Exercise-Induced Cardiac Remodeling in Health and Disease -- Cardiac microvascular endothelial cells and pressure overload-induced cardiac fibrosis -- Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenesis -- Computational biomechanics of ventricular dyssynchrony and resynchronization therapy -- Therapeutic innovations for heart failure.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783031239649
    Additional Edition: Printed edition: ISBN 9783031239663
    Additional Edition: Printed edition: ISBN 9783031239670
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    UID:
    gbv_1753058953
    Format: 1 Online-Ressource(XI, 352 p. 49 illus., 40 illus. in color.)
    Edition: 1st ed. 2021.
    ISBN: 9783030631642
    Series Statement: Cardiac and Vascular Biology 8
    Content: Preface -- Hemodynamics and vascular remodeling -- The biomechanics of venous remodeling -- New kids on the block: the emerging role of YAP/TAZ in vascular cell mechano-transduction -- GPCRs und flow and pressure -- Biomechanics in small artery remodeling -- Contributions of wall stretch and shear stress to vascular regulation: Molecular mechanisms of homeostasis and expansion -- Mechanobiology of lymphatic vessels -- Hemodynamic control of endothelial cell fates in development -- Mechanical regulation of epigenetic modifications in vascular biology and pathobiology -- Mechanosensing and mechanotransduction in pulmonary hypertension -- Mechanobiology of arterial hypertension -- Mechanobiology of atherosclerosis -- Exploitation of vascular mechanobiology for cardiovascular therapy.
    Content: This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiacmechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
    Additional Edition: ISBN 9783030631635
    Additional Edition: ISBN 9783030631659
    Additional Edition: ISBN 9783030631666
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030631635
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030631659
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030631666
    Language: English
    Keywords: Gefäßsystem ; Gefäßkrankheit ; Biomechanik
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing, | Cham :Springer.
    UID:
    almafu_BV048918788
    Format: 1 Online-Ressource (VIII, 353 p. 1 illus).
    Edition: 1st ed. 2023
    ISBN: 978-3-031-23965-6
    Series Statement: Cardiac and Vascular Biology 9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23964-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23966-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-23967-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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