In:
International Journal of Cancer, Wiley, Vol. 144, No. 10 ( 2019-05-15), p. 2529-2538
Abstract:
What's new? Pancreatic inflammation contributes to oncogenic Kras‐driven pancreatic ductal adenocarcinoma (PDAC). Little is known, however, about differences between pancreatic acinar cells and ductal cells regarding susceptibility to oncogenic Kras. Here, initiation of pre‐neoplastic lesions from the acinar or ductal cellular compartment was found to be related to inflammation type and extent. In oncogenic Kras mice, ductal obstruction caused severe pancreatitis with transient ductal cell proliferation and further induced a proliferative phenotype in oncogenic Kras‐expressing ductal cells, with pathological features resembling those of pre‐neoplastic lesions. The findings highlight the significance of cell type‐dependent diversity in PDAC malignant transformation pathways.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Bookmarklink