In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 660 ( 2022-08-31)
Abstract:
Preventing cardiomyocyte death helps preserve cardiac function after myocardial infarction (MI). Here, Ruozi et al. developed cardiac FunSel, an adeno-associated virus (AAV) vector–based screen, to identify cardioprotective proteins in mice. Injecting pooled AAV9 barcoded vectors into the hearts of mice revealed several previously unidentified secreted factors associated with cardiomyocyte survival after MI. Secretion of three select proteins (chordin-like 1 and family with sequence similarity 3 members B and C) using liver-specific AAVs in mice limited maladaptive cardiac remodeling and preserved cardiac function after MI by promoting autophagy and cell survival and inhibiting fibrosis. This in vivo screening method could help identify cardioprotective therapeutic targets.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abo0699
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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