In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 46, No. 5-6 ( 1991-6-1), p. 442-450
Abstract:
A novel enzyme inhibitor of RNA -directed DNA -polym erases of avian myeloblastosis and murine leukemia virus was isolated from fermentations of an tasmanian Podoscypha species. Its structure was elucidated by spectroscopic methods and oxidative degradation as (E)-4,5- dioxo-2-hexadecenoic acid (1). The enzyme inhibitor, which was named podoscyphic acid, did not inhibit DNA and RNA synthesis in permeabilized L 1210 cells nor did it affect RNA synthesis in isolated nuclei of L 1210 cells. 1 inhibits protein synthesis in whole L 1210 cells and rabbit reticulocyte lysate and shows very weak antimicrobial and cytotoxic properties. The testing of ethyl (E) 4,5-dioxo-2-hexadecenoate (2) and (E)-4-oxo-2-tetradecenoic acid (11) revealed the importance of the free y-oxoacrylic acid unit for the biological activities of 1
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-1991-5-617
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
1991
detail.hit.zdb_id:
2078107-6
SSG:
12
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