In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 78, No. 5-6 ( 2023-05-25), p. 169-177
Abstract:
In the present study, it was evaluated the chemical composition and the antinociceptive activity of the essential oil obtained from the leaves of Guatteria friesiana . Seven compounds corresponding to 96.2% of the crude essential oil were identified. The main components identified were the mixture of β-eudesmol and α-eudesmol (58.1%), and γ-eudesmol (16.8%). A new α-eudesmol derivative, named 5-hydroxy-α-eudesmol, was isolated together with the known compounds β-eudesmol and a mixture of α-eudesmol, β-eudesmol and γ -eudesmol of the essential oil. The chemical structures were determined by 1D and 2D NMR, and MS experiments. Essential oil has significant antinociceptive properties, which are related probably with the involvement of the opioid receptors and K + -ATP channels.
Type of Medium:
Online Resource
ISSN:
0939-5075
,
1865-7125
DOI:
10.1515/znc-2022-0059
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2023
detail.hit.zdb_id:
2078107-6
SSG:
12
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