In:
International Journal of Cancer, Wiley, Vol. 137, No. 12 ( 2015-12-15), p. 2947-2958
Abstract:
What's new? Chemotherapy and EGFR‐TKIs may produce enhanced effect when combined together, but this is influenced by the choice of the drug and the sequence of administration. This study reports that NSCLC cell line carrying the EGFR‐L858R/T790M mutations showed increased sensitivity to the sequential schedule of vinorelbine followed by gefitinib in vitro and in vivo . These preclinical findings support the application of this treatment scheme in lung tumors poorly responsive to reversible EGFR‐TKIs.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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