In:
Cancer Medicine, Wiley, Vol. 4, No. 11 ( 2015-11), p. 1700-1704
Abstract:
The Barrett's and Esophageal Adenocarcinoma Consortium ( BEACON ) recently performed a genome‐wide association study ( GWAS ) on esophageal adenocarcinoma ( EAC ) and Barrett's esophagus. They identified genome‐wide significant association for variants at three genes, namely CRTC 1 , FOXP 1 , and BARX 1 . Furthermore, they replicated an association at the FOXF 1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P 〈 10 −4 in the BEACON sample. In total, we tested 88 SNP s in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP 1 , BARX 1 , and FOXF 1 with nominal significance and thereby confirm that genetic variants at these genes confer EAC risk. In addition, we found association of variants near the genes XRCC 2 and GATA 6 that were strongly ( P 〈 10 −5 ) although not genome‐wide significantly associated with the BEACON GWAS . Therefore, both variants and corresponding genes represent promising candidates for future EAC association studies on independent samples.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2015.4.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2659751-2
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