In:
Veterinary Record, Wiley, Vol. 188, No. 5 ( 2021-03)
Abstract:
Background : The use of concurrent medications is necessary in trials of treatment of canine atopic dermatitis. Our aim was to use the best available evidence to construct and then to validate a medication score (MS) formula that will estimate the impact of concurrent medications on trial outcomes. Methods : Trials of 15 interventions were scrutinized to find those that were consistent in terms of specific medication, administration route and dosage regimen. A MS was constructed in five steps, starting from assigning a score of 1 for each day on oral prednisone, prednisolone or methylprednisolone at 0.5–1.0 mg/kg. The MS score was validated using the clinical records of 35 dogs with atopic dermatitis that had been treated for a period of 12 ± 2 weeks with six of these medications and compared with a previously published non‐validated MS. Results : A MS could be assigned to eight treatments, six of which had been administered to the 35 dogs. A positive correlation was seen with the previously published MS and a negative correlation with changes in lesional and pruritus scores. Conclusion : This MS may be a useful tool in new studies evaluating the efficacy of treatments in canine atopic dermatitis
Type of Medium:
Online Resource
ISSN:
0042-4900
,
2042-7670
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2106609-7
detail.hit.zdb_id:
2919192-0
SSG:
22
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