In:
The Journal of Physiology, Wiley, Vol. 598, No. 17 ( 2020-09), p. 3667-3689
Abstract:
Desmin, similar to dystrophin, is associated with costameric structures bridging sarcomeres to the extracellular matrix. Deletion of the desmin gene in mdx mice [double knockout (DKO) mice] induces marked muscle weakness and fatigue resistance compared to mdx mice. Muscle fragility (higher susceptibility to contraction‐induced injury) was also aggravated in DKO mice compared to mdx mice. By contrast to mdx mice, the DKO mice did not undergo muscle hypertrophy. Desmin cDNA transfer with adeno‐associated virus in newborn mdx mice reduced muscle weakness. Overall, desmin plays important and beneficial roles in muscle wasting, performance and fragility in dystrophic muscle.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475290-6
SSG:
12
Bookmarklink