In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 193, No. 4 ( 2008-10), p. 338-339
Abstract:
Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.107.043497
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2008
detail.hit.zdb_id:
2021500-9
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