In:
American Journal of Medical Genetics Part A, Wiley, Vol. 170, No. 10 ( 2016-10), p. 2671-2680
Abstract:
Studies during the past 50 years demonstrate the importance of chromosome abnormalities to the occurrence of early pregnancy loss in humans. Intriguingly, there appears to be considerable variation in the rates of chromosome abnormality, with more recent studies typically reporting higher levels than those reported in early studies of spontaneous abortions. We were interested in examining the basis for these differences and accordingly, we reviewed studies of spontaneous abortions conducted in our laboratories over a 40‐year‐time span. Our analyses confirm a higher rate of abnormality in more recent series of spontaneous abortions, but indicate that the effect is largely, if not entirely, attributable to changes over time in the maternal age structures of the study populations. © 2016 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1552-4825
,
1552-4833
DOI:
10.1002/ajmg.a.v170.10
DOI:
10.1002/ajmg.a.37795
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1493479-6
SSG:
12
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