In:
Journal of Oncology, Hindawi Limited, Vol. 2008 ( 2008), p. 1-6
Abstract:
Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptor CXCR 4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence of CXCR 4 expression on the progression of human renal cell carcinoma. CXCR 4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity of CXCR 4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities of CXCR 4 expression. Strong CXCR 4 expression of renal cell carcinoma was significantly associated with advanced T-status ( P = .039 ), tumor dedifferentiation ( P = .0005), and low hemoglobin ( P = .039). In summary, strong CXCR 4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.
Type of Medium:
Online Resource
ISSN:
1687-8450
,
1687-8469
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2008
detail.hit.zdb_id:
2461349-6
Bookmarklink